JAMA Psychiatry

More than 10% of US youth and nearly half of adults with mental health conditions turn to generative AI for advice or support, highlighting the need for clinicians to routinely ask about #AI use in mental health care. ja.ma/4cM2myj

Disease development trajectories in #MentalDisorders vary by diagnosis at first contact, sex, and age, with younger patients exhibiting more diagnostic shifts and psychiatric contacts, highlighting the need for targeted preventive care. ja.ma/3Rrh6tW

A network meta-analysis indicates that FDA-approved adjunctive atypical antipsychotics for #Depression differ in efficacy and acceptability, with lumateperone highest for efficacy and aripiprazole for acceptability. ja.ma/3Rn3GPD

#PsychedelicTherapy was not more effective than open-label traditional antidepressants for major #Depression. Blinding improved outcomes for antidepressants but not for psychedelic-assisted therapy. ja.ma/4wtUuJt

#DigitalInterventions for #EatingDisorders produced consistent, durable improvements in core symptoms and comorbid mental health outcomes in randomized clinical trials across acute and follow-up periods. ja.ma/4f3xTgw

Among outpatients with #BorderlinePersonalityDisorder, dialectical behavior therapy and schema therapy produced similar and substantial improvements in symptoms, functioning, and quality of life, with no significant differences in treatment retention. ja.ma/4d8tXty

The first European Board Examination in Psychiatry had 161 candidates from 36 countries and a 91% pass rate, supporting efforts to harmonize psychiatric training standards. ja.ma/4tuGWdS

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4u57Nyi

Functional unblinding and expectation may confound efficacy signals in #Psilocybin trials for #Depression, making it difficult to isolate therapeutic effects of psychedelic experiences from placebo and expectancy responses. ja.ma/4eFSuHJ

Adult sleep GWAS-derived polygenic scores demonstrated comparable associations with corresponding sleep phenotypes in #Adolescents, suggesting genetic influences on sleep persist across developmental stages. ja.ma/4tZ9JIx

#Ketamine infusions reduced suicidal and depressive symptoms rapidly in patients with a major depressive episode, with transient adverse events resolving during trials; longer-term outcomes remain unclear. ja.ma/431IZv6

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4nsTh0T

Street psychiatry for people experiencing unsheltered #Homelessness relies on temporary public and private grants, while sustainable expansion will require health plan payment reforms and broader Medicaid reimbursement for outreach-based care. ja.ma/4dz5pKg

A network meta-analysis indicates that FDA-approved adjunctive atypical antipsychotics for #Depression differ in efficacy and acceptability, with lumateperone highest for efficacy and aripiprazole for acceptability. ja.ma/3P4uu6G

#Ketamine infusions reduced suicidal and depressive symptoms rapidly in patients with a major depressive episode, with transient adverse events resolving during trials; longer-term outcomes remain unclear. ja.ma/3PaFYWf

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4uxiB8n

In overweight or obese patients with #Depression, adjunctive oral semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/3R2X3Sp

In overweight or obese patients with #Depression, adjunctive oral semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/4n9XnLd

A multimedia antistigma campaign and a primary care health worker-led digital intervention improved knowledge, attitudes, and behavior toward mental health and reduced depressive symptoms among adolescents in Indian slums. ja.ma/4unJeww

A multimedia antistigma campaign and a primary care health worker-led digital intervention improved knowledge, attitudes, and behavior toward mental health and reduced depressive symptoms among adolescents in Indian slums. ja.ma/4vUsjD7