JAMA Psychiatry

#PsychedelicTherapy was not more effective than open-label traditional antidepressants for major #Depression. Blinding improved outcomes for antidepressants but not for psychedelic-assisted therapy. ja.ma/4rE3S9C

Functional unblinding and expectation may confound efficacy signals in #Psilocybin trials for #Depression, making it difficult to isolate therapeutic effects of psychedelic experiences from placebo and expectancy responses. ja.ma/4slMM1A

Elevated plasma #pTau181 and #NfL levels in #AlzheimerDisease patients largely reflect broad neuropsychiatric impairment rather than psychosis alone. ja.ma/4uf42qO

Individuals with chronic opioid use, with or without opioid addiction, exhibited stronger learning from negative reinforcement and reduced choice consistency, supporting preclinical models of avoidance-driven behaviors. ja.ma/4aOvVy6

A cross-sectional study of adults affected by the 2023 Maui wildfires demonstrated that wildfire exposure was associated with higher rates of #depression and #anxiety compared to unexposed individuals, with risk extending beyond burn zones. ja.ma/4rzKz1s

This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional #MentalHealth frameworks. ja.ma/4sJvGuj

The first European Board Examination in Psychiatry had 161 candidates from 36 countries and a 91% pass rate, supporting efforts to harmonize psychiatric training standards. ja.ma/3Pam9xQ

Ambient #AI scribes increased documentation of neuropsychiatric symptoms in primary care, but were associated with lower rates of psychiatric intervention compared with unscribed visits. ja.ma/47aOsCq

This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional #MentalHealth frameworks. ja.ma/4rrTJgk

Among US #Veterans, higher cumulative burden of adverse social determinants of health was associated with greater risk of past-year suicidal ideation, suicide attempt, and future suicidal intent. ja.ma/4l9GD5S

From @JAMA_current: State-level decriminalization of #Psilocybin in Oregon in 2020 and Colorado in 2022 was associated with increased 12-month psilocybin use compared with synthetic control estimates. ja.ma/411L9df

A cross-sectional study of adults affected by the 2023 Maui wildfires demonstrated that wildfire exposure was associated with higher rates of #depression and #anxiety compared to unexposed individuals, with risk extending beyond burn zones. ja.ma/4bmfaJw

Higher cumulative adverse prenatal exposure burden was associated with persistent increases in psychopathology risk and accelerated cortical thinning in adolescents, with dose-dependent effects confirmed in sibling comparisons. ja.ma/4ra0Qd6

For patients with #FirstEpisodePsychosis unresponsive to initial antipsychotic therapy, clozapine improved symptom response rates and reduced discontinuation due to insufficient efficacy vs olanzapine or amisulpride. ja.ma/4uodHeC

📢 This Special Communication recommends hybrid survey designs—combining online panels with probability samples—as a new standard for psychiatric epidemiological research. ja.ma/4leVDzw

Systematic review and meta-analysis: #PTSD, depressive, anxiety, and sleep disorders were associated with increased risk of #AcuteCoronarySyndrome, while bipolar and psychotic disorders were not significantly associated. ja.ma/40FhNkO

Among adults with #Depression, complex antidepressant treatment patterns were associated with higher polygenic risk for psychiatric traits but not with sustained use of a single antidepressant. ja.ma/4b6ceAC

Chronic, delayed, and shifting patterns of PTSD, CPTSD, and PGD were linked to higher levels of somatization and pain, highlighting the need for integrated trauma-informed care addressing physical and psychological health. ja.ma/4cY8fZt

Health plan disenrollment after initiating medications for #OpioidUseDisorder was associated with increased all-cause and overdose mortality compared with remaining enrolled. ja.ma/4b4X00h

An umbrella review found #NatureBased interventions yield moderate improvements in tension, fatigue, confusion, and affect, but evidence for climate-related psychosocial interventions remains limited. ja.ma/3P2NMc3