JAMA Psychiatry

Dan-Mircea Mirea, PhD, and John Torous, MD, discuss how receiving more “likes” on social media posts led to greater increases in posting among users with #depression compared to those without depression. 🎧 Listen now: ja.ma/4f52ZCN

Military sexual trauma prevalence remains high among US veterans, especially females, and is associated with increased risk for suicidal thoughts and behaviors. ja.ma/4yiaUFK

📄JAMA Psychiatry #Review: Functional unblinding was common in most #psychedelic randomized clinical trials for psychiatric disorders, with >70% correctly identifying treatment allocation, raising concerns for trial validity. ja.ma/3TuRDAM

Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/3QYQMaV

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4vlh598

A pluralistic model of #Schizophrenia recognizes multiple #neurochemical and cellular mechanisms, not just #dopaminergic #dysregulation, to help explain symptom heterogeneity and guide #biomarker-informed, mechanism-based treatment development. ja.ma/4f2ZMDL

Disrupted #gastrointestinal interoception predicted relapse and symptom severity in weight-restored females with #AnorexiaNervosa, supporting ingestible mechanosensory probes as scalable tools for monitoring and relapse prevention. ja.ma/4biVN4V

#Depressive #psychopathology was associated with a greater tendency to be reinforced by social media likes, suggesting a potential mechanism linking social media use and worse #MentalHealth. ja.ma/3TcPsSp

In #overweight or #obese patients with #Depression, adjunctive oral #semaglutide reduced effort discounting and improved motivation on a validated effort-expenditure task compared with placebo. ja.ma/4wefMdL

Among patients with #Schizophrenia treated with antipsychotics, semaglutide, liraglutide, topiramate, metformin, and exenatide were associated with the greatest reductions in body weight. ja.ma/4wx5N2L

💬 Editorial: Individuals with higher depression symptoms show increased sensitivity to social media likes, raising questions about platform design, reward, and potential risks for vulnerable groups. ja.ma/4f5oa7H

A network meta-analysis indicates that FDA-approved adjunctive atypical antipsychotics for #Depression differ in efficacy and acceptability, with lumateperone highest for efficacy and aripiprazole for acceptability. ja.ma/4v9w0mW

#DigitalInterventions for #EatingDisorders produced consistent, durable improvements in core symptoms and comorbid mental health outcomes in randomized clinical trials across acute and follow-up periods. ja.ma/4p4a779

#Ketamine infusions reduced suicidal and depressive symptoms rapidly in patients with a major depressive episode, with transient adverse events resolving during trials; longer-term outcomes remain unclear. ja.ma/44DAibk

Intermittent #ThetaBurst stimulation targeting the dorsomedial prefrontal cortex enhanced placebo-induced mood improvement by potentiating default mode network activity in adults with depressive symptoms. ja.ma/4gTf3JP

Targeted psychological and psychosocial interventions for #Schizophrenia, including avatar therapy, reduced the severity of #AuditoryHallucinations with small to medium effects and high acceptability. ja.ma/4vERXeA

Disrupted #gastrointestinal interoception predicted relapse and symptom severity in weight-restored females with #AnorexiaNervosa, supporting ingestible mechanosensory probes as scalable tools for monitoring and relapse prevention. ja.ma/4ya62CD

A multimedia antistigma campaign and a primary care health worker-led digital intervention improved knowledge, attitudes, and behavior toward mental health and reduced depressive symptoms among adolescents in Indian slums. ja.ma/4wqIRlS

In adults with acute #Schizophrenia, once-daily LB-102 provided greater symptom reduction than placebo over 4 weeks and was generally well tolerated, showing a manageable safety profile and low rates of extrapyramidal symptoms. ja.ma/4v9vZPU

Systematic Review: Greater exposure to adverse #SocialDeterminants was associated with #neurobiological abnormalities in #Schizophrenia spectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/4xTONVQ