JAMA Surgery

An #AI-derived electronic tumor marker, e19-9, demonstrated utility as a noninvasive biomarker for treatment response and prognosis among patients with #PancreaticCancer who do not produce elevated CA19-9. ja.ma/4se03Jv

An #AI-derived electronic tumor marker, e19-9, demonstrated utility as a noninvasive biomarker for treatment response and prognosis among patients with #PancreaticCancer who do not produce elevated CA19-9. ja.ma/4ryFEgZ

The 2025 WSES #Appendicitis guidelines recommend risk stratification and imaging for diagnosis, outpatient antibiotics for uncomplicated cases, and laparoscopic surgery within 24 hours for surgical management. ja.ma/4sjm7SQ

The volume of inguinal #hernia repairs in the Veterans Health Administration grew by nearly 50% from 2002 to 2022, with the use of minimally invasive approaches rising from 9% to 41%. ja.ma/4bQh4Ug

Risk-reducing bilateral mastectomy was associated with lower overall and breast cancer–specific mortality in female carriers of #BRCA1 and #BRCA2 pathogenic variants. ja.ma/40ucwMU

Among adults hospitalized with emergency general surgery (#EGS) conditions, those with high-risk diagnoses experienced lower rates of mortality and complications in hospitals using an EGS care model. ja.ma/40paYns

Among African surgical trainees, women reported more mistreatment by coworkers and patients than men. Organizational support within PAACS was perceived as more equitable than other staff groups. ja.ma/3OY23Hc

A national survey found that most US adults favor licensure for internationally trained surgeons amid physician shortages, yet have reservations about training equivalence and personal selection for care. ja.ma/4cKqIsC

More than 500 000 patients in the US are hemodialysis dependent. This Review summarizes current knowledge and recommended strategies for managing well-recognized complications associated with AV access. ja.ma/413kKvC

In this qualitative study, surgeons cited slow access to #AI case data, limited complication prediction, and few research deliverables as major barriers to adoption. ja.ma/4cJkj0P

In older patients with frailty and #GastricCancer, ≥2 weeks of supervised, home-based multimodal #Prehabilitation reduced postoperative complications and enhanced functional capacity vs ERAS alone. ja.ma/47tTsCh

Medicaid expansion was associated with reduced mortality and increased surgical resection rates for patients with #PancreaticCancer, with improvements most evident several years after expansion and for those with stage II-III disease. ja.ma/4aWqc9F

Neoadjuvant chemotherapy did not improve disease-free survival vs upfront surgery in patients with locally advanced #ColonCancer, but reduced need for adjuvant chemotherapy and showed safety and feasibility. ja.ma/4sB0b5H

Use of #GLP1 receptor agonists surged among patients eligible for metabolic and #BariatricSurgery from 2018 to 2025, while surgery utilization decreased by nearly half, especially for sleeve gastrectomy. ja.ma/4cZXmX0

Among patients with single-site de novo metastatic #BreastCancer, breast primary resection with or without locally ablative therapy was associated with improved overall survival, while ablative therapy at the metastatic site alone was not. ja.ma/4aGvV38

Medicaid expansion was associated with reduced mortality and increased surgical resection rates for patients with #PancreaticCancer, with improvements most evident several years after expansion and for those with stage II-III disease. ja.ma/4ujSlz9

Effective January 12, 2026, JAMA Surgery is excited to announce the appointment of David A. Gerber, MD, to the Editorial Board. ja.ma/4bgJbM4

Neoadjuvant chemotherapy did not improve disease-free survival vs upfront surgery in patients with locally advanced #ColonCancer, but reduced need for adjuvant chemotherapy and showed safety and feasibility. ja.ma/4l4ELLE

Opening a level 1 trauma center in a Chicago trauma desert reduced travel time and distance to care and was associated with a significant decrease in firearm mortality in the affected area. ja.ma/4kQy6o2

Laparoscopic adhesiolysis for #SmallBowelObstruction was not superior to open surgery for long-term recurrence, incisional hernia incidence, or quality of life at 5-year follow-up, confirming both as viable options. ja.ma/4sdMMQB