Cephalalgia

In this video, Dr Nina Riggins interviews Dr Zixuan Alice Zhang and Professor Messoud Ashina about their publication in Cephalalgia, selected as the Editor’s Choice for the April issue. The study examined whether blocking hyperpolarisation-activated cyclic nucleotide-gated channels with ivabradine could modify KATP-induced migraine in humans or hypersensitivity in mice. The main finding: ivabradine failed to modify KATP-induced migraine in humans or hypersensitivity in mice. This suggests that hyperpolarisation-activated cyclic nucleotide-gated channels are unlikely to be key downstream mediators, while vascular-to-neuronal signalling may be important in migraine initiation. You can find the video on our YouTube channel. youtu.be/rVbElkcVhAg?si… Link to the paper: journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience @NinaRiggins @Simona_Sacco_ @MessoudAshina

Applications are now open for the 2026–2027 Cephalalgia Reviewer Academy! 🧠📚 A unique mentored training programme by Cephalalgia and Cephalalgia Reports, designed to support the next generation of expert peer reviewers in headache research. ✅ Structured peer-review training ✅ Mentorship and supervised practice ✅ Formal certification ✅ Open to researchers and healthcare professionals ✅ No age limit 📅 Deadline: 14 June 2026 A great opportunity to develop your peer-review skills, strengthen headache research, and contribute to the scientific community. 🔗 Apply now / More information: ihs-headache.org/en/news/applic… #Cephalalgia #HeadacheResearch #Migraine #PeerReview #Neurology #HeadacheMedicine #AcademicMedicine #EarlyCareerResearchers

New in Cephalalgia! Migraine mechanisms remain unclear. Magnetic resonance spectroscopy (MRS) non-invasively measures brain neurochemical changes across diffrent region, but ictal findings across brain regions are inconsistent. More research is needed. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience @MessoudAshina @h_ashina @HaidarAlKhazal2

New in Cephalalgia Reports! This study aimed to compare nortriptyline monotherapy and combination therapy in the treatment of recurrent migraine of moderate frequency. Combination prophylaxis may offer superior frequency reduction in moderate-frequency episodic migraine. • Improved efficacy may enhance adherence and persistence. • Lower-dose polytherapy may preserve tolerability. journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience @neurocefaleia @doresdecabeca

New in Cephalalgia! Prospective study of 1,642 patients reveals Anxiety and Analgesic Overuse as key drivers of Migraine Chronification in China, while Exercise offers protection. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia Reports! This study examined associations between IL-6R gene polymorphisms and migraine in a Japanese population. Our results suggest a possible link between IL-6R variants and migraine, supporting a role for inflammatory pathways in migraine. journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia Reports! This study reports an 84-year-old with Acute Confusional Migraine mimicking stroke. This case highlights acute confusional migraine as a critical differential in the elderly, challenging its pediatric exclusivity. journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia Reports! A Delphi study assessed how non-factual impressions aid headache diagnosis. Only two statements reached consensus: a “familiar” headache suggests a primary cause, while an “unfamiliar” one may indicate a secondary headache. journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience @HeikoPohl1

New in Cephalalgia Reports! First case of interstitial pneumonia linked to galcanezumab for migraine. Key finding: inverted CD4/CD8 ratio on BAL. Full recovery after stopping treatment. Anti-CGRP antibodies may rarely cause pulmonary adverse events journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia Reports! A Delphi round with 19 headache experts helped achieve consensus on: treatment response assessment criteria and timepoint, defining non-response to therapy, triptan usage, tolerability, and comorbidities within the Indian clinical context. journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia Reports! In this study, migraine patients showed no increased video head impulse testing (vHIT) asymmetry vs controls, supporting preserved Vestibulo-ocular reflex (VOR). Yet, higher asymmetry—even within normal range—was associated with greater dizziness-related disability. 🧠🌀 journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience @Alex__Jaimes

New in Cephalalgia Reports! Flow cytometry reveals a link between T-cell immunoglobulin and mucin-domain containing-3 (TIM3) expression on cytotoxic T cells and headache frequency. TIM3, a potential biomarker of migraine chronification? Further studies are needed! journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia! Some individuals without headache consider headaches a trivial problem, with females being more empathetic toward peopl with headache. Headache-related stigma appears to be a real problem, even among administrative body employees. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia Reports! This study shows that people with migraine may face driving risks similar to those with epilepsy. Individualized assessment—considering aura, cognitive fog, vestibular symptoms, and patients’ own perceptions—could help improve driving safety. journals.sagepub.com/doi/10.1177/25… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia! The estimated disability weight (DW) of 0.432 indicates a substantial patient-reported health loss specific to Spontaneous intracranial hypotension (SIH) prior to definitive treatment. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience @KathaDCwolf @Niklas_Luetzen

New in Cephalalgia! This systematic review summarizes the evidence on pharmacologic treatments for post-traumatic headache. Some therapies show potential benefit, but the overall evidence base remains limited and higher-quality trials are needed. Given the limited high-quality evidence overall, no specific clinical recommendations can be made at this time. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia! Across 21 trials with 7,032 patients, CGRP-targeted therapies may reduce migraine days and improve response in those with prior preventive treatment failure. Findings rely on limited evidence and longer independent studies are still needed journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience @faradoost

New in Cephalalgia! Domain-specific machine-learning models currently provide more reliable diagnostic performance compared to large language models (LLMs). A supervised machine-learning model trained on real-world clinical data showed better agreement with a specialist-confirmed diagnosis than a general-purpose, zero-shot, non-domain-adapted LLM. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience @MasahitoKatsuki

New in Cephalalgia! Minimal physical activity was associated with lower migraine-related disability and better life satisfaction. The identification of an activity engagement threshold and distinct patient clusters suggests a staged care model where pharmacologic stabilization enables physical activity, which may itself serve as a marker of recovery. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience

New in Cephalalgia!. Green-enriched white light is the most visually comfortable and causes the least physiological sensitivity compared to blue- and cyan-enriched white lights. journals.sagepub.com/doi/epdf/10.11… #migraine #headache #brain #pain #neurology #neuroscience @schwedtt