Journal of Experimental Medicine

CD163 and Tim-4 identify resident intestinal #macrophages that are spatially regulated by TGF-β. From Vignesh Jayaraman, Ian E. Prise of the @grainger_konkel & @tovah_shaw labs hubs.la/Q04nXVFM0 📘 In #Mucosal #Immunology collection: 👉 hubs.la/Q04nXZ5w0 #ICMI2026

IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @RoserTP, @HabibBashour, Filipska et al. (@victorgreiff & Cerutti labs) hubs.la/Q04nY9vW0 📘 In #Mucosal #Immunology collection: 👉 hubs.la/Q04nXWQM0 #ICMI2026

B7 costimulation antagonizes RORγt+ regulatory T cells and immune #tolerance in the intestine. From Mengze Lyu and Gregory F. Sonnenberg: hubs.la/Q04nYv300 📘 Part of our #Mucosal #Immunology collection: 👉 hubs.la/Q04nY9YW0 #ICMI2026

LINGO4 coordinates #ILC3-intrinsic IL-22 production and #microbiota-mediated ILC3 homeostasis, from José Fachi, Tihana Trsan et al. from @TheColonnaLab: hubs.la/Q04nXVB70 📘 Part of our #Mucosal #Immunology collection: 👉 hubs.la/Q04nYbln0 #ICMI2026

Excited to share new research from PICI Center Director @wolchokj, PICI researchers Taha Merghoub, Mohamad Hamieh, and other researchers from @WeillCornell Medicine, where they highlight a promising new approach to treating bladder cancer. Published in the @JExpMed, the study identifies MUC16 as a promising target for CAR T cell therapy and demonstrates that delivering CAR T cells directly into the bladder effectively controls tumors in preclinical models while minimizing systemic toxicity. These findings could help pave the way for new bladder-sparing treatment options for patients with therapy-resistant disease. Learn more here: rupress.org/jem/article/22…

Antibiotic use in early life impairs #MAIT cell–mediated immunity in adulthood. From LeBlanc, Sobel, Constantinides @MGClab and colleagues: hubs.la/Q04nY3Z00 📘 Part of our #Mucosal #Immunology collection: 👉 hubs.la/Q04nYjgl0 #ICMI2026

CSF1R-dependent CD169-positive #macrophages locally constrain #melanoma growth in the skin. From Yuki Honda Keith, Tri Giang Phan and colleagues: hubs.la/Q04nXXxs0 📘 Part of our #Mucosal #Immunology collection: 👉 hubs.la/Q04nYBDT0 #ICMI2026

@UCSF Read a recent paper in JEM from Arielle Klepper and colleagues, "Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens" 👉 rupress.org/jem/article/22…

“Another person in our group may even replicate an experimental approach suggested by one of the reviewers.” — Arielle Klepper, @UCSF. Receive clear and constructive guidance on your next manuscript. 👉 hubs.la/Q04lZtsq0

#Fibroblast diversity within human gut-associated lymphoid tissues. From Urs Mörbe, William Agace and colleagues: hubs.la/Q04nXWsb0 📘 Part of our #Mucosal #Immunology collection: 👉 hubs.la/Q04nYbNm0 #ICMI2026

A signal-responsive cooperative transcription factor network determines alveolar #macrophage identity. From Mínguez-Martínez, Porcuna et al. of the @MRicoteLab: hubs.la/Q04nY2wj0 📘 Part of our #Mucosal #Immunology collection: 👉 hubs.la/Q04nXWzT0 #ICMI2026

Are you headed to #ICMI2026 @socmucimm in Montréal? Interested in speaking with a JEM editor? Get in touch with our Senior Editor Montse Cols @montse_jexpmed, who will be there! ✉️ hubs.la/Q04nWTq10 See our new collection 👉 hubs.la/Q04nWTG20

📘 💡 Explore our special collection of recent research articles on the interface between the immune system and the environment at mucosal surfaces, timed to coincide with the #ICMI2026 @socmucimm in Montréal! 👉 hubs.la/Q04nVXy-0

Excited to share this “Insight” @JExpMed about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!

Rabia Nabi, Chien-Wei Lin, Yu Wang, Yi-Guang Chen et al. @medicalcollege show that both soluble & membrane forms of CD137 expressed by Foxp3+ CD4 T cells are critical for immunoregulation, & they independently restrain #T1D development hubs.la/Q04nNmTr0 #Diabetes

🤩Glad to see our work on the cover of @JExpMed 🥳

Schroeder et al. from the Hui Hu lab (hubs.la/Q04nDdXC0) report that the transcription factor BACH2 has context-dependent dual functions in regulating the differentiation of follicular T helper cells. Jinfang Zhu (NIAID) discusses the findings: hubs.la/Q04nCC9j0

IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (hubs.la/Q04nCCfZ0) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @Lo_Zanzi highlights the findings: hubs.la/Q04nC-CF0

New Review: Chang, Sloan et al. describe how peripheral neurons shape #SolidTumors through interactions with #cancer, immune, vascular, and stromal cells and highlight the therapeutic potential of targeting neural pathways to improve treatment response. hubs.la/Q04nC-RJ0

Zhou et al. identify a new mechanism driving kidney #fibrosis. They reveal that IFN-λ, produced by renal tubular epithelial cells, directly activates renal fibroblasts to cause fibrogenesis. Blocking IFN-λ signaling can delay progression of renal fibrosis. hubs.la/Q04nCCNP0