Journal of Experimental Medicine

RIPK1 autophosphorylation at S161 mediates cell death and #inflammation. From Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis: hubs.la/Q046W1Ln0 📘 In our #InnateImmunity collection: hubs.la/Q046V-0W0 #KSInnateImmune26

This collection highlights recent JEM studies investigating the adaptive and innate immune response induced by M. #tuberculosis and HIV-1 infection. Read new findings to accompany @KeystoneSymp meetings on #TB and #HIV Vaccines: hubs.la/Q046W5q50 #KSTB26 #KSHIVVax26

Does fever drive the #evolution of antiviral genes? Perspective by Ryan Langlois @langloislab.bsky.social hubs.la/Q046W3dM0 📘 In our #InnateImmunity collection: hubs.la/Q046W1_f0 #KSInnateImmune26

Single-cell and spatial profiling highlights #TB-induced myofibroblasts as drivers of lung pathology. From Ian Mbano and colleagues: hubs.la/Q046Wj_S0 📘 Updates on the Immune Responses to #Tuberculosis and #HIV: hubs.la/Q046Ws2X0 #KSTB26 #KSHIVVax26

Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1, from Ran Liu, Gengqiao Wang, Zhengting Jiang, Jinyang Gu et al. hubs.la/Q046W0lk0 📘 In our #InnateImmunity collection: hubs.la/Q046V_jV0 #KSInnateImmune26

New research out in @JExpMed examining viral dynamics with co-authors including Janet Siliciano and Robert Siliciano. rupress.org/jem/article/22…

New study from Chen et al. identifies #hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived #macrophages in the ischemic brain after #stroke through mediating phosphatidylcholine synthesis. hubs.la/Q047kYb30

ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense, from Cunzhen Li et al.: hubs.la/Q046VW9p0 📘 In our #InnateImmunity collection: hubs.la/Q046VSdp0 #KSInnateImmune26

Our new collection highlights the latest discoveries in the field of #InnateImmunity in viral infection, barrier defense, liver health, inflammation, and cancer. Explore latest discoveries to accompany @KeystoneSymp on the topic: hubs.la/Q046VSWq0 #KSInnateImmune26

Results were published in 2023 @JExpMed, showing that ~40% (15–50) of WNV encephalitis (1 out of 2 pts. who died of WNV) carried these auto‑Abs. We performed experiments that provided indirect but compelling evidence for a causative role of these auto‑Abs. rupress.org/jem/article/22…

Elated for this amazing work of @nogales_pons @mariolamuna & TAG with @Casanova_Acebes taking over the rudder to finally come out ✨ WHERE 🪹, WHEN ⏳, and WHY 🤔 are MYELOID CELLS *NOW* in the TME? Go check this beautiful review ‼️🧫

Our latest review has come out in @JExpMed !! If you want to know more about Myeloid heterogeneity in tumors, hubs diversity and circadian rhythms, check this review out!! 💕 Congrats to all the autors that contributed to create this masterpiece🤩 rupress.org/jem/article/22…

Myeloid cells infiltrate tumors from early transformation to advanced disease; however, their plasticity complicates therapeutic targeting. Nogales-Pons et al @Casanova_Acebes review emerging technologies that uncover unexpected cellular states & functions hubs.la/Q046y-Bs0

New work from Chaorui Duan, William Fairbrother et al. @BrownUniversity reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. hubs.la/Q046yXQl0 #InnateImmunity #Inflammation

New from Wei-Yao Chin, Shi-Chuen Miaw et al.: #macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility. hubs.la/Q046y-5q0 #Immunology #Mitochondria #Ak4

@InstitutImagine (2/2) In a separate cohort, they identify asymptomatic individuals lacking the HAQ allele and an HAQ-positive COPA patient with kidney disease, suggesting that STING haplotype alone does not fully account for disease expression in COPA syndrome.

Clémence David, Marie-Louise Frémond et al. @InstitutImagine investigate whether the common HAQ STING allele explains clinical non-penetrance in COPA syndrome. (1/2) hubs.la/Q046bPBz0 #HumanDiseaseGenetics #InnateImmunity #inflammation

New from AHRI in @JExpMed & on the cover! 📸 shows a human TB granuloma in lung tissue. The red, green & yellow cells shown, for example, are all different type of macrophage - immune cells that fight infection by engulfing & killing microbes like Mtb 🔗 rupress.org/jem/article/22…

ICYMI: this collection highlights the latest JEM studies in lymphatic biology, incl. studies on lymphatic vessels in the skin, skull, intestine, and lung, novel imaging techniques, and the role of lymphatic vessels in various pathologies. hubs.la/Q043Vmgh0

1/ The 33rd Annual Henry Kunkel Society Meeting will be held April 16–18, 2026, at @RockefellerUniv in New York. The theme is “Autoantibodies Against Cytokines.”