Dr Matthias Jansen 🇵🇸

@Gregs_iPinions @SaltyGoat17 Are you implying George Floyd was murdered with this AI slop? You realise AI is responsible for a whole lot more layoffs than the failure of this merger, right?

@SaltyGoat17 It’s the ridiculous action of the Biden administration blocking the JetBlue Spirit merger which eventually led to its closure, and Elizabeth Warren championed it at the time.

Way to go Democrats!! You cost 17,000 American jobs by not allowing the JetBlue-Spirit merger...

@SaltyGoat17 Are Democrats solely to blame though? Layoffs are more common following mergers as the company restructures. Layoffs are still inevitable given the fuel crisis causing fewer people to fly. That's how capitalism works. It's a structural issue not a partisan one.

@Sachinettiyil It is not standard practice to offer MAID to patients without solicitation in Canada. If you really believed in God, would you not feel ashamed for lying when he knows what is in your head?

A 79-year-old Catholic priest, Fr. Larry Holland, who is recovering from a hip fracture at Vancouver General Hospital in Canada, said he was offered Medical Assistance in Dying (MAiD) twice by hospital staff, even though he made clear he is a Catholic priest and morally opposed to euthanasia. Image: BC Catholic

@sanilrege 10 is the most important point IMO. I hate the word "adaptogen" as it's been misused by a lot of pseudoscience peddlers but SSRIs can be thought of as an adaptogen by enhancing emotional regulation and cognitive flexibility.

Great thread ! Here are some points from the article I wrote in 2021 updated over time How SSRIs act ✅ 1. Serotonin synapses are present brain wide and consist of 14 different receptor types 2. SSRIs do not simply “correct low serotonin.”
 3. The older serotonergic hypothesis of depression has been superseded by a more complex model involving serotonin signalling, receptor adaptation, neuroplasticity, emotional processing, inflammation, and network-level effects. 4. The primary pharmacological action is SERT inhibition.
 As Tyler states clearly 👉This is the initiating mechanism, but not the full explanation for clinical response. 5. Early receptor effects explain both early side effects and delayed benefit.
 6. Increased serotonin initially stimulates postsynaptic 5-HT2A, 5-HT2C and 5-HT3 receptors, contributing to early adverse effects such as gastrointestinal disturbance, anxiety, agitation, sleep disturbance or sexual dysfunction. Some receptor effects attenuate over 1–2 weeks as receptors adapt, although not all side effects resolve. 7. Delayed antidepressant onset relates partly to autoreceptor adaptation. 
5-HT1A autoreceptors initially inhibit serotonergic neuronal firing. With repeated SSRI exposure, these autoreceptors desensitise/downregulate over several weeks, allowing enhanced serotonergic transmission through projection pathways. This helps explain the clinical lag in antidepressant effect. 8. SSRIs influence emotional processing early.
 Before mood visibly improves, SSRIs may shift appraisal of emotionally valenced information for example, reducing negative bias and altering amygdala-related processing. This may be one reason behavioural and cognitive changes emerge before full symptomatic remission. It also explains the prominent anti-anxiety effect 9. SSRIs also modulate noradrenaline and dopamine indirectly. 
Serotonergic projections can inhibit noradrenergic neurons in the locus coeruleus via 5-HT2A effects on GABA interneurons, and can also inhibit dopaminergic neurons in the VTA. This may contribute to anxiolysis in some patients, but also to emotional blunting, apathy, reduced reward sensitivity or poor response in others. 10. Clinical response involves neuroplasticity, not just monoamine levels. 
SSRIs may enhance BDNF signalling and act at the TrkB receptor, facilitating synaptic plasticity, neurogenesis and adaptive circuit remodelling in regions implicated in depression. 11. 5-HT1A signalling appears important for hippocampal neurogenesis. 
Chronic SSRI treatment increases serotonin, activates 5-HT receptors in the dentate gyrus, and may promote downstream growth factors such as BDNF and VEGF, supporting neural precursor cell proliferation and integration. 12. Astrocytes may be part of the SSRI mechanism. 
Depression is increasingly linked with glial dysfunction, excitatory–inhibitory imbalance and altered neurotrophic support. SSRIs may affect astrocytic Kir4.1 channels, influencing neuronal excitability, glutamate regulation and BDNF secretion. 13. SSRIs may have anti-inflammatory effects. 
SSRIs may reduce neuroinflammatory signalling through effects on cytokines, NF-κB, inflammasomes, TLR4 and PPARγ pathways. 14. Serotonin is best understood as a brain-wide modulatory system.
 Serotonin neurons arise from relatively small nuclei but project widely, influencing inhibition, aversive processing, impulsivity, aggression, panic, reward bias and behavioural flexibility. There are multiple serotonin receptor subtypes, each with distinct distributions and functional effects. Key message : 
 -SSRIs act as modulators of emotional salience, threat appraisal, plasticity and network adaptation. -Their benefit is not simply “more serotonin,” but the downstream consequence of receptor adaptation, altered affective processing, improved plasticity, and broader changes across serotonergic, noradrenergic, dopaminergic, glial and inflammatory systems.

@trumplicans2024 Is that an AI generated image?

true for me, you?

@Lina_rays1ya Investigate everyone in the Epstein Files. It's what Charlie Kirk wanted.

Would you keep supporting Harrison Ford knowing he is against Trump? ✋ A ) YES 🙋 B ) NO 🙅

@captgouda24 What time period were they are communist country? Did you actually put any thought into this tweet at all? Do you need to be reminded to breathe?

It is no surprise that Britain is struggling; after all, they were for many years a communist country.

@captgouda24 You're not autistic or smart so you are doubly as insufferable.

Autism becomes so much tolerable when they're really smart. Have you ever talked with an autistic person who's not that bright? They just repeat the same facts over and over again. It's very tiresome. At least you always get new facts, and new insights, even if it's one-sided.

@GigaBasedDad I honestly cannot determine what argument, if any, is being made here. I will just assume this was entirely generated by AI and my search for meaning is a waste of time.

Clearly one is superior

@thehealthb0t HBV can be transmitted from mother to child. It's pretty simple and I am not sure why people keep feigning ignorance.

The Hepatitis B vaccine is mandated for children to attend public schools in 46 states. Hepatitis B is transmitted via needles or sexual contact, yet this vaccine is pushed on babies on their first day of life.

@DavidJHarrisJr I hope you do get the attention you are seeking but I kinda think most people will just ignore you.

Gonna have some fun traveling today…

@Cairo_xprsk Is this what they call engagement farming?

Do you agree? Yes or No??

@TinashePeter_ Ok but some people did want those people dead. Also I have questions about the legitimacy of this profile. Are you really the person in your PFP and banner?

I disliked Obama, Never wanted him dead. I disliked Biden, Never wanted him dead, I though Kamala was an idiot, Never wanted her dead. You see that leftists? That’s what we can being SANE.

@DrHappygrowl @SavajBunny You did well. You're a great doctor. Make sure you sleep well so you can keep being a great doctor.

Hitting hard today, but still always a privilege I’m going to sleep, time to refresh 💤 🎨 @SavajBunny

@DrAnnieHickox What do you mean by "critical ideology"?

@JMatthiasMD MAHA and ‘critical’ ideology share many goals, and some criticals are contributing to health/employment policy making in the US and U.K..

Horse shoe theory strikes again! Odd how closely communist ideology overlaps with authoritarian neoliberalism. MAHA is welcoming ‘criticals’ with open arms, I imagine.

@DrAnnieHickox Why do I feel like people who think ADHD/autism is a myth also believe vaccines cause autism?

I hope the ‘ADHD/Autism is a myth’ crew are proud of their minor contributions to the reduction of special needs support and recognition. theguardian.com/education/2026…

@roxydoxy1527 @CNNSOTU Do you really believe that? Does posting on social media help reinforce your delusions? Does having people challenge you make you feel more vindicated? I really wanna know what's going on inside your head.

@CNNSOTU Elise won the debate before poor Jake ever opened his mouth!

Jake Tapper to Rep. Elise Stefanik: “Is calling for wiping out an entire civilization bad or good?”

@SinCuentaEstrel @CNNSOTU When the students were chanting "from the river to the sea", were they talking about genocide?

@CNNSOTU Jake Tapper is a retard. its clear that Trump was referring to the Iranian regime. that civilization of oppression being what would be destroyed. CNN is obsessed with attacking Trump so of course they don't give him any grace while at the same time airing Iranian propaganda.