Jason Sheltzer

Check out our new study in @ScienceMagazine, where we take on a 100-year-old debate: what’s the role of aneuploidy in cancer? We discovered that genetically removing extra chromosomes blocks cancer growth - a phenomenon we call “aneuploidy addiction”. science.org/doi/10.1126/sc…

Sounds great - we're recruiting right now! x.com/JSheltzer/stat…

@exosome yes - aneuploidy is an under-appreciated driver of cancer, aging, and other significant conditions. we showed that in cancer, if you eliminate specific aneuploid chromosomes, you block malignant growth.

Elimination of extra chromosome in #cancer makes cancer become normal... Stunning paper @JSheltzer did I understand it correctly ? science.org/doi/10.1126/sc…

Challenges in Drug Discovery: Biology— Paul Workman and Jason M. Sheltzer will address this topic in a special session at the AACR D3 Conference on Drug Discovery and Development (July 21-24; Boston). Learn more: brnw.ch/21x2wGk #AACRdrugdev26 @JSheltzer

My lab at @Stanford is looking to hire postdocs for multiple projects on cancer biology and therapeutics. Our recent work has uncovered some truly remarkable mechanisms for cytotoxic small molecules and we're looking to build on this research. If interested, see below:

This work was led by first-author @DrKlaske, working together with @S_J_Aitken @ZStorchova @akalu_saron and many others. biorxiv.org/content/10.648…

Moving forward, we’re excited to identify UBE2H’s targets in diploid vs. aneuploid cells and to examine the consequences of acutely eliminating UBE2H in various therapeutic settings.

Thrilled to share my lab’s new preprint describing our discovery of the E2 ubiquitin conjugating enzyme UBE2H as a widely-shared dependency in aneuploid cancer cells. @biorxivpreprint @biorxiv_cancer

GLP-1 drugs are the ultimate validation of the techno-solutionist approach to society's most challenging problems. The obesity crisis seemed liked it would just get worse and worse forever. Scolding from public health officials didn't work. Proposals to completely overhaul our food systems were dead on arrival. Instead, we invented a weekly shot (based on Gila monster venom!) that fixes obesity directly. And now, thanks to the economic incentives in our biomedical industry, we have follow-on drugs that will be cheaper, even more effective, and easier to administer (by taking a pill instead of a shot). Policymakers should be focused on figuring out how we can get more breakthrough drugs like GLP-1s (and faster). They also should think hard about which slopulist ideas might inadvertently kill the goose that lays the golden eggs.

@xinjin @perturbai_tx congrats Xin!

Today, I am thrilled to introduce @PerturbAI_Tx, a company I co-founded to rethink drug discovery. Biology is complex, and disease unfolds across genes, cell types, and tissues. We’re powering AI with the causal logic of human genetics: perturb.ai

Not sure how many people have noticed this: In the latest (Mar 4) release of 24 new research papers from Nature (top science journal), 8 came from the US and 8 came from China. nature.com/nature/researc… Among the 29 new research papers in Cell (top journal in biomedical sciences) released this year, 8 came from the US while 10 came from China. cell.com/cell/newarticl… Meanwhile US labs are suffering from the aftermath of the NIH/NSF funding disruptions - including drastically reduced funding rates and as a result diminishing lab sizes and competitiveness in #STEM research.

We think that the chromosome engineering techniques that we’ve developed through this work will be broadly useful for creating isogenic models of other complex rearrangements associated with developmental syndromes. If you’re interested in collaborating, please get in touch!

This project was a fantastic collaboration with the Pinter Lab at UConn and the Davoli Lab at NYU. We’re grateful to @chromosome8p for supporting this work and for the individuals who provided the samples used in this analysis. genome.cshlp.org/content/36/3/5…

Thrilled to share my lab’s new paper out in @genomeresearch where we use chromosome engineering to deconstruct 8p syndrome - a rare developmental condition caused by inversions, duplications, and deletions on chromosome 8p.