Jack Mislinski

VO2max is back at the center of longevity discourse yet again, and it’s catching both skepticism and defense as a biomarker. both are warranted, and i want to get into why, through the story of my recent max test. yesterday i ran to failure on a treadmill in our UCCS exercise physiology lab and got mine measured directly with a homemade metabolic cart validated against douglas bags as a part of our graduate studies. my result? 63 ml/kg/min. or was it 70? maybe 57? the reality is these tests are messy. here’s the importance, reality, and application of modern VO2 tests 🧵…

@DaveShapi demonization of cortisol is an outdated and unhelpful narrative. hubermans work to illuminate the circadian nature of healthy cortisol function is very important. high in the morning is good, low at night is good.

Being dead also decreases cortisol Choose your utility function carefully

@misraetel see the “mad scientist” trope that’s overplayed in hollywood… but how many of our smartest humans are evil?

It's beyond debate in my view (I don't literally mean that, it's just one-sided) that ASI will be able to toast all of us after it has billions of robots and runs the majority of the economy. The real question is: why would it kill us, instead of study us. Us, whose society and ecosystem is the most complex thing in the known universe. The best possible training data. So far, every doomer idea about this smuggles "it's likely" in with "it's possible." You can go to the pound right now, get a dog, and toast it. Easy. Free. But you don't. And those who do are typically not the smartest. There must be a why. Before you answer... remember... the ASI will be smarter than you. Don't give it one-liner lizard motives, please.

i have 42 more where that came from… the solo founder will only be limited by their ideas and willingness to prompt them. physical ai hands them everything else. the window is open. but most aren’t looking at it yet.

here are 8 you can run with in 2030: → continuous chest ecg node feeding real-time hrv to an agent that cues closed-loop vagus nerve stimulation during parasympathetic windows → home ultrasound scanning your tendons and joints every morning, flagging changes before you feel them, adjusting your training load automatically → exhaled breath metabolomics — a bathroom device reading your voc profile at wake-up to diagnose your metabolic state before you eat anything → circulating tumor dna liquid biopsy running continuously as a personal cancer early warning system → real-time electrochemical neurotransmitter sensing — dopamine and serotonin tracked in interstitial fluid, closing the loop to transcranial stimulation when a focus window collapses → autophagy induction timing via an agent reading your glucose, ketones, and activity state to tell you the exact moment to fast or train for maximum cellular cleanup → synthetic biology implants producing therapeutic peptides on demand in response to your own internal biochemical signals → somatic mutation accumulation tracking — watching your genome drift in real time as a true aging clock

the entrepreneurial window won’t close as ai matures… a solo founder in 2030 will have more leverage to attack a hard problem than a well-funded startup had attacking a far simpler one in 2022. the scarcity of capital and access to tools are collapsing. nowhere is this more true than in biotech… and i can think of 50 companies waiting to be built:

health data is swiss cheese. every slice has holes. your watch, your blood panel, your sleep metrics, your cgm — all individually useful, all incomplete. whoop can’t give you a biological age from heart rate alone. your doctor can’t call you “optimal” just because you’re “within range” on apoB. the goal is to stack slices until the holes disappear. but even a few sources become too much for any one person to hold in context. you just can’t synthesize it all. that’s why it’s the perfect job for ai agents. and we’re almost there.

food quality isn’t a property of food. it’s an interaction between the food and your specific bioenvironment across two axes. metabolic: how you handle energy. not just “sugar spikes insulin” but when, after what, in whose body. 100g sugar mid-race vs. a cup of rice for a T2D produce wildly different outcomes. immunological: how you respond to what you eat. intestinal permeability, microbiome, and food-specific immune responses. think AGEs and nitrites and allergies. most people are aware of general metabolic properties. but almost nobody considers individualized effects or the immunological side. you’re the most important variable that nutrition advice isn’t accounting for.

a prerequisite for keeping up with the benefits of ai is near-weekly interrogation of which of the things you don’t want to do can now be automated. the models move fast enough that the answer changes constantly.

open-sourced podex a week ago. but google just dropped gemini 3.1 flash tts — sounds more natural than elevenlabs and drops cost from ~$2 to ~$0.30 per 10-min episode. for a daily, personalized, studio-quality podcast on whatever you’re into, feed this repo to your llm: github.com/jackmis610/pod…

how to get mega-rich from the singularity: step 1: live in the us step 2: don't die

link: cell.com/cell/fulltext/…

this is the most ridiculous scientific publication i have ever seen... a one time crispr injection, plus periodic electromagnetic modulation, allowed for remotely controlled modulation of the yamanka factors in mice. currently a moonshot for human translation... tissue specificity, device engineering, crispr delivery mechanism... but this is a cheap and entirely new longevity vector that could keep us young remotely. a mind-blowing advance toward longevity escape velocity.

@Brady_H the most promising in this arena is urolithin-a. seems to actually improve performance (up to a certain fitness level). but it’s also stupid expensive. no free lunches yet, but they’re coming. pubmed.ncbi.nlm.nih.gov/35584623/

Metformin. Rapamycin. Both “longevity drugs” hyped by “longevity influencers.” And now evidence that both interfere w/ adaptations to exercise. No free lunch in biology.

a good knife cuts well. a good shovel digs well. what does a good human do? plato and aristotle believed every human is born with an inherited purpose — a fixed essence preceding existence. this is essentialism. existentialism disagrees. it says we arrive without a purpose. no assigned meaning, no predetermined role. just a world that offers no answers. existentialists call this absurdity. in the face of it, you are fully responsible for designing your own moral code. you can borrow from religions, philosophies, authorities — but those systems were built by people just like you. people who also had to figure it out. no one is coming with the answer. accepting that… fully… is the prerequisite to living authentically. and authenticity is exhilarating.

@DaveShapi the human paperclip problem. “oh ai has potential to cause destruction? -> we must stop ai -> i will cause destruction to stop ai.”

@signulll same, then i wonder what the future tech looks like to make it less weird and awkward. one can imagine cameras that are everywhere and always on, with a kind of gaussian splitting to make everything visible in most public (and private, only if you choose) places. minority report.

every time i watch some influencer video, i always think about the camera, positioning, whether there is a tripod or a light involved. esp if it’s highly emotional (crying or something else) cuz you as the audience are given such an authentic view as if everything is just always recorded magically like a reality tv show. as if the influencer didn’t set up the camera before crying. most ppl never realize the enormous amount of effort it takes to record your life esp as a solo influencer. imagine you have to do retakes or whatever (lol like crying again). imagine being around someone who is living this lifestyle. & increasingly it’s a fuck ton of ppl. social media now is almost all performance art disguised as the ultimate reality & most ppl never even question it.

reminds me of the great alan watts quote: “Let's suppose that you were able every night to dream any dream that you wanted to dream. And that you could, for example, have the power within one night to dream 75 years of time. Or any length of time you wanted to have. And you would, naturally as you began on this adventure of dreams, you would fulfill all your wishes. You would have every kind of pleasure you could conceive. And after several nights of 75 years of total pleasure each, you would say "Well, that was pretty great." But now let's have a surprise. Let's have a dream which isn't under control. Where something is gonna happen to me that I don't know what it's going to be. And you would dig that and come out of that and say "Wow, that was a close shave, wasn't it?" And then you would get more and more adventurous, and you would make further and further out gambles as to what you would dream. And finally, you would dream ... where you are now. You would dream the dream of living the life that you are actually living today.”

chaos is the tax you pay for being in a universe where anything can happen. the irony is that a ton of ppl say they want peace, but what they actually want is a little danger, a little uncertainty if you will, a little chaos.