JAMA Cardiology

In a US cohort, higher systolic #BloodPressure genetic risk was associated with new-onset #Hypertension after pregnancy, but elevated postpartum body mass index and hypertensive disorders of pregnancy were stronger risk factors. ja.ma/41spGKS

Among patients with diabetes and multivessel coronary artery disease, ticagrelor was not noninferior to prasugrel for reducing death, myocardial infarction, stroke, or major bleeding at 1 year after percutaneous coronary intervention. ja.ma/4vCYcjw

💬 Editorial: HeartSync-LBBP found #CSP superior to #BiVP for heart failure outcomes, whereas PhysioSync-HF found CSP inferior, emphasizing the importance of patient selection and operator proficiency. ja.ma/4m8DmEc

Among asymptomatic patients with severe #AorticStenosis, higher midwall myocardial fibrosis burden was associated with increased death or unplanned hospitalization, but early valve intervention results did not differ by fibrosis burden. ja.ma/483BQh2

Among patients with heart failure and LBBB, LBBP demonstrated superior long-term clinical outcomes compared to BiVP, driven primarily by reduced rates of heart failure hospitalization. ja.ma/4tdAvNj

Patients with #HeartFailure showed increased myocardial fibroblast activation using [68Ga]FAPI-46 PET/MRI, with distinct patterns by cardiomyopathy etiology, highlighting activated fibroblasts as a potential therapeutic target. ja.ma/3QpBqvg

📢 Now accepting applications: 2026–2027 JAMA Cardiology Editorial Fellowship Early-career cardiologists and researchers: elevate your academic trajectory by serving as a participating member of the JAMA Cardiology Editorial team. 🔗 Apply by May 15: ja.ma/4mFXaPF

#Type2Diabetes patients at high cardiovascular risk receiving oral #semaglutide demonstrated early and sustained improvements in glycated hemoglobin, body weight, systolic blood pressure, and lipid profiles vs placebo. ja.ma/4vbuMZy

In patients with #HeartFailure and #LBBB, conduction system pacing (#CSP) was inferior to biventricular pacing (#BiVP) for a composite of death, heart failure events, and LVEF change at 12 months. ja.ma/3O23Ef2

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention. ja.ma/4vytGaA

Food supplementation with medically tailored meals or fresh produce was feasible and well accepted in patients with #HeartFailure but did not reduce hospitalizations or emergency visits compared to usual care. ja.ma/4cnNQes

💬 Editorial: Adverse pregnancy outcomes, especially hypertensive disorders, are linked to higher risk of premature #CardiovascularDisease. Pregnancy presents a key window for CV risk assessment and counseling. ja.ma/4mah4C1

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term #CardiovascularDisease risk in pregnant women. ja.ma/421Qbad

Among patients with anterior myocardial infarction, adding low-dose rivaroxaban to dual antiplatelet therapy did not significantly reduce left ventricular thrombus formation at 1 month but increased minor bleeding. ja.ma/41rVvn3

Burst exercise testing detected more severe ventricular arrhythmias and prompted treatment escalation more often than the Bruce protocol in patients with #CPVT, with no observed safety concerns. ja.ma/4mhqKea

In a US cohort, higher systolic #BloodPressure genetic risk was associated with new-onset #Hypertension after pregnancy, but elevated postpartum body mass index and hypertensive disorders of pregnancy were stronger risk factors. ja.ma/47PEc2S

RBM20 truncating variants were associated with reduced lifetime penetrance and milder disease in #DilatedCardiomyopathy compared to pathogenic RBM20 or titin variants, suggesting a low-effect role in arrhythmogenic cardiomyopathy. ja.ma/3PVA779

Food supplementation with medically tailored meals or fresh produce was feasible and well accepted in patients with #HeartFailure but did not reduce hospitalizations or emergency visits compared to usual care. ja.ma/3Qn4cg0

#Type2Diabetes patients at high cardiovascular risk receiving oral #semaglutide demonstrated early and sustained improvements in glycated hemoglobin, body weight, systolic blood pressure, and lipid profiles vs placebo. ja.ma/4tBdhjY

In a US cohort, higher systolic #BloodPressure genetic risk was associated with new-onset #Hypertension after pregnancy, but elevated postpartum body mass index and hypertensive disorders of pregnancy were stronger risk factors. ja.ma/3NTY26s