James Birrell

763 posts

James Birrell

James Birrell

@JamesBirrell86

Colchester, England Katılım Nisan 2019
176 Takip Edilen405 Takipçiler
James Birrell retweetledi
Patricia Rodriguez Macia
Patricia Rodriguez Macia@_PatriRM·
@IR_PAAsh @JamesBirrell86 @SimoneMorra8 and I cannot wait to welcome you in Leicester next year for the International Conference on Hydrogenase and other Redox Metalloenzymes!
ICH2026@ICH2026

We are delighted to confirm the dates of the international conference on H2ases and other redox metalloenzymes, which will take place from 26 to 30 July 2026 at Leicester (UK). The confirmed plenary speakers are already announced on our website👇 le.ac.uk/chemistry/rese…

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ICH2026
ICH2026@ICH2026·
Stay tuned and visit our website for more updates (coming very soon), and we look forward to seeing you all next year at Leicester for a week of fantastic science and fun!
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ICH2026
ICH2026@ICH2026·
We are delighted to confirm the dates of the international conference on H2ases and other redox metalloenzymes, which will take place from 26 to 30 July 2026 at Leicester (UK). The confirmed plenary speakers are already announced on our website👇 le.ac.uk/chemistry/rese…
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James Birrell retweetledi
University of Essex
University of Essex@Uni_of_Essex·
Studying at our Colchester Campus puts you close to the heart of a historic city known for everything from arts and culture to water sports. Explore the renowned Colchester Zoo, go vintage shopping or just relax in the city's cafes, bars and restaurants. brnw.ch/21wTrdO
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James Birrell
James Birrell@JamesBirrell86·
Thanks to @horch_lab and the rest of his awesome team, especially Cornelius Bernitzky and Yvonne Rippers. I also want to thank @_PatriRM for help with preparation of beautiful [FeFe] hydrogenase samples.
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James Birrell
James Birrell@JamesBirrell86·
Overall, 2DIR is a fantastic technique that extends the utility of IR spectroscopy applied to hydrogenases and other redox metalloenzymes. Not only can measurements be performed at ambient temperature, it is non-destructive, and high quality spectra are obtained in short time.
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James Birrell
James Birrell@JamesBirrell86·
3) The terminal COs form a strongly coupled pair where the peaks in linear IR spectra should be treated as antisymmetric & symmetric modes. 4) Computation of anharmonicities is fairly insensitive to the protein surrounding, suggesting these can help predict active site structures
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James Birrell
James Birrell@JamesBirrell86·
Takehomes: 1) The best structural model is that previously determined with X-ray crystallography. 2) The terminal CN ligands & bridging CO behave as isolated vibrational oscillators. 3) The higher energy CN vibration in the Hinact state is attributed to the CN on the distal Fe.
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James Birrell
James Birrell@JamesBirrell86·
In this proof of concept study we apply 2DIR to the O2 stable Hinact state of the [FeFe] H2ase from D. desulfuricans. 2DIR allows extraction of intra- and intermode anharmonicities. Combined with computations this provides exquisite insight into active site structure & dynamics.
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James Birrell retweetledi
Fidel Ramírez
Fidel Ramírez@fidelormz·
I'm truly excited to announce our new publication in @Nature unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @AnujR2d2 for the fantastic illustration! LINK: nature.com/articles/s4158…
Fidel Ramírez tweet media
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Keşfet

@IR_PAAsh @SimoneMorra8 @horch_lab @CLF_STFC @ChemistryatYork @_PatriRM @ChemicalScience @Nature