James Hutchinson

Our trial protocol is out - first-in-human allogeneic macrophages for the treatment of paracetamol liver injury. Can they fill the gap between acetylcysteine and transplant? bmjopen.bmj.com/content/14/12/… @EdinClinTox

Proteolytic shedding of CD46 from human hepatocytes indicates liver stress: Heliyon cell.com/heliyon/fullte…

Don't miss our collaborative study proposing combined therapy for #MultipleSclerosis Targeting #AhR w/ #DMF restores #tolerogenic #DendriticCells properties | A basis for new clinical trials @FedericoFonde @Eva_M_C @GTRecerca @CarrerasIJC @hgermanstrias jci.org/articles/view/…

First Class Doctorate for Federico! ⁦@INsTRuCT_h2020⁩

The August issue of Transplantation picked-up Dataset Restriction as a Research Highlight. Find the full article by Collin Z Jordan at doi.org/10.1097/TP.000…

Restriction also helps with intraclass heterogeneity. An unanticipated consequence of restriction is that disease biomarkers with a bimodal distribution in the positive class, such as might arise from multiple aetiologies, are findable. #biomarkers #predictive_models #ROC_curve

Health implies homeostasis, whereas disease means dysregulation. It shouldn’t surprise us that disease markers are often more variably expressed in patients than controls @ExtraHorizon_ @INsTRuCT_h2020 @GGlehr @die_paloma #melanoma #irAE

Combination cell therapy leads to clonal deletion of donor-specific T cells in kidney transplant recipients - eBioMedicine thelancet.com/journals/ebiom…

Social media and scientific publishing. Why it's important for authors and readers to follow articles from Transplantation and Transplantation Direct. Our editor @BaanCarla explains!

IL-4+ iNKT cells are a mechanistically surprising subset in hepatic steatosis that certainly deserve more attention. Congratulations to Florian, Paul, Raphael and Giulia!

Congratulations Maria for graduating Cum Laude! @INsTRuCT_h2020 👩🏻‍🎓

Immune profiling of adipose tissue lymphocytes from patients with peritoneal carcinomatosis undergoing CRS-HIPEC leads to interesting new hypotheses. Good job, Julia! doi.org/10.1007/s00262…

New article by Florian and Jordi - well done. Case report: Predictability of clinical response and rejection risk after immune checkpoint inhibition in liver transplantation frontiersin.org/articles/10.33…

The Extra project is looking for PhD candidates: ✅If you are willing to relocate to Barcelona ✅Have a background in translational Immunology & flow cytometry ✅ Are interested in the field of solid organ transplantation Please check out the link (workpack DoC9) @Inmunocanruti

exTra is a spin-off from INsTRuCT focused on apoptotic cell therapy in solid organ transplantation. If you’re looking for a PhD project with translational relevance, apply to exTra before 15th August, 2023.

Our new article about dataset restriction was released today as a #preprint on @researchsquare: researchsquare.com/article/rs-292…