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The NETMOTION study is published in JAMA Pediatrics today ,🌟🌟🌟
See the full paper here:
jamanetwork.com/journals/jamap…
Breaking down the results below ⤵️👇 🧵
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James Sotiropoulos
76 posts
James Sotiropoulos
@James_Sot
Junior Doctor | PhD Candiate at NHMRC Clinical Trials Centre, University of Sydney
Katılım Temmuz 2022
135 Takip Edilen59 Takipçiler
Excited to share our new publication in @JClinEpi on using individual participant data for risk of bias assessments. IPD informed assessments might reduce uncertainty and help increase confidence in the evidence base
NHMRC CTC@TrialsCentre
Two new @JClinEpi papers from @TrialsCentre offer practical methods to improve trial transparency & systematic reviews. IPD-informed bias checks & registry reporting reforms could reshape evidence synthesis. Read them here👉bit.ly/414rg5S & bit.ly/4mL0fwP
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James Sotiropoulos retweetledi
🌟🌟 Massive Congratulations to @KylieEHunter from @TrialsCentre for winning the Thomas Chalmers Award at the Global Evidence Summit 2024! 🌟 🌟
Her winning presentation was on the IPDIntegrityTool, which is available here➡️ lnkd.in/gRG7gsc9
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James Sotiropoulos retweetledi
🎧 New Episode of #journalclub is out!
Check out episode #224 of the podcast for more: buff.ly/3VSZKEV
#neotwitter #medtwitter #nicuverse #pedsICU #cardiology #nicu #innovation #podcast #babies #children
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Check out @nicupodcast's new journal club episode where I unpack some of the #NETMOTION results. Thanks for having me @DoctorDaphnaMd
#neotwitter #MedTwitter
open.spotify.com/episode/1Zy016…
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Consider voting for our article in @EBNEO article of the month poll 😄
Evidence-Based Neo@EBNEO
Laing al. Vs Sotiropoulos: Which paper posted by @EBNeo during June is most likely to impact your neonatal practice? Vote now for Impact Article of the Month on our website! buff.ly/43ahAWK #EBNeoPolls
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James Sotiropoulos retweetledi
The majority of voters will continue to resuscitate preterm infants with 30% to 40% O2. Paper does challenge the current recommendations given difference in mortality in High-vs-low but also discusses low certainty of this finding and complexity of this important question. Where to now? Looking forward to some clarity in coming few years from HiLo, Torpido30,60, OptiSTART, DOXIE trials. Goal: Better outcomes for our newborns. #neotwitter
Vishal Kapadia@KapadiaNeo
After reading @JAMAPediatrics paper, I will start resuscitation of preterm babies <32 weeks with following oxygen concentration. @AAPneonatal #neotwitter @Research4Babies @NICU_Musings @ccroehr @drbretty @natetexsun @BrianKingNeo @James_Sot @LeneSeidler jamanetwork.com/journals/jamap…
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James Sotiropoulos retweetledi
High initial oxygen (90-100%) for resuscitation of preterm infants less than 32 weeks may be associated with reduced deaths, finds study from the NETMOTION Collaboration. ja.ma/3XDzbGy
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@DrAbdulRazak_MD @EBNEO @JAMAPediatrics @grpolglase @Atul_Monash Thanks @DrAbdulRazak_MD - agree with all your points. Those issues prompted the low/very low CoE ratings.
Ongoing studies are critical!
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@EBNEO @JAMAPediatrics @James_Sot @grpolglase @Atul_Monash 4. Biased studies (lots of reds/yellows)
5. Highly heterogeneous in terms of titration
IMO, this is a very important paper alerting us to be careful with what we are doing but I would look forward for TORPIDO, HILO to get some more insights
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James Sotiropoulos retweetledi
A meta-analysis in @JAMAPediatrics by @James_Sot et al. evaluates mortality by initial resuscitation FiO2 in infants born <32 weeks buff.ly/4blWDv9
#EBNEOalerts #neoEBM #neotwitter
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Thanks @EBNEO for sharing and summarising the key findings
All the discussion around the results has been fascinating
#neotwitter
Evidence-Based Neo@EBNEO
A meta-analysis in @JAMAPediatrics by @James_Sot et al. evaluates mortality by initial resuscitation FiO2 in infants born <32 weeks buff.ly/4blWDv9 #EBNEOalerts #neoEBM #neotwitter
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James Sotiropoulos retweetledi
📢 New Research 🔬
Do higher oxygen concentrations help prevent death in very premature babies?
New research from the NETMOTION study led by @James_Sot, @LeneSeidler and @KylieEHunter from the @syd_health @TrialsCentre, published in @JAMAPediatrics hopes to help answer this question.
Read more about the research here 👉 rb.gy/l3f2x8
Read the full paper here👉 rb.gy/wjppqy
#LeadershipForGood #ClinicalResearch #PrematureBabies
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James Sotiropoulos retweetledi
@Dr_KSGautham What we did find from looking into titration is that after 4 minutes the delivered FiO2 was relatively similar across the three groups.
There are some nice figures in eAppendix 8 that explore this 👇
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@Dr_KSGautham Certainly. The slow vs fast titration definition was somewhat arbitrary, but we drew a line based on how fast the study protocols allowed FiO2 to be adjusted each minute.
This didn't work, as the studies titrated too heterogeneously. So we couldn't run this planned analysis.
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The NETMOTION study is published in JAMA Pediatrics today ,🌟🌟🌟
See the full paper here:
jamanetwork.com/journals/jamap…
Breaking down the results below ⤵️👇 🧵
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@James_Sot Congrats on a much needed study! Would you be able to provide the full text? I was trying to read it but our library won't access it until is on a print issue. Thanks and congratulations again
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@drbretty @KapadiaNeo @JAMAPediatrics @AAPneonatal @Research4Babies @NICU_Musings @ccroehr @natetexsun @BrianKingNeo @LeneSeidler Agree with @KapadiaNeo and @Research4Babies. Evidence is not yet strong, but should give us confidence to re-examine high initial FiO2 in more trials!
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@James_Sot @KapadiaNeo @JAMAPediatrics @AAPneonatal @Research4Babies @NICU_Musings @ccroehr @natetexsun @BrianKingNeo @LeneSeidler You don’t get off that easily @James_Sot! What will you and your co-authors be doing? Changing to higher FiO2 or awaiting results of more trials?
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After reading @JAMAPediatrics paper, I will start resuscitation of preterm babies <32 weeks with following oxygen concentration. @AAPneonatal #neotwitter @Research4Babies @NICU_Musings @ccroehr @drbretty @natetexsun @BrianKingNeo @James_Sot @LeneSeidler jamanetwork.com/journals/jamap…
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@BrianKingNeo 3.) Yes, as you found we looked at a few different sets of priors in the supplement 😄 We also compared to frequentists models and got similar results
See in 1.) re: how nodes were grouped
Let me know if anything else needs clarification
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@James_Sot Found #3 in your appendix!
I see as a SA you split into 4 categories (21%, 30%, 50-65% and >90%). Still wonder if 30-65% vs >90% would yield anything interesting. Maybe it's simply "some oxygen", even the smallest amount?
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@BrianKingNeo I agree it would make sense to see a possible variation across the GA spectrum.
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@BrianKingNeo 2.) I think this is a question of statistical power. Interaction effects for network meta analysis are still a relatively new area. They need quite large sample sizes to reach significance. Without speculating too much, I think we will see more about this in future updates.
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