Javier Perez-Garcia

Happy to announce my new position as a Postdoctoral Scholar at @Stanford @StanfordMed. So grateful to Dr. Andres Cardenas @cardenaasca for giving me this unique oportunity to study multiomics and GxE interactions in complex diseases. Much to learn and grow in this new chapter!

#Environment, #Microbiome and #Epithelial Barriers According to the Epithelial Barrier Theory, disruption of tight junctions by environmental toxins, such as detergents, pollutants, and microplastics, drives the disease pathogenesis of many chronic inflammatory conditions. This structural breakdown facilitates the translocation of allergens and pathogens through the epithelial barrier into deeper tissue, promoting microbial dysbiosis and sustained immune activation. The cover of this issue illustrates this critical interface by depicting the developing microbiome of a child. The artwork highlights the early "window of opportunity" in childhood, during which the development of a diverse microbiome and the maturation of the protective epithelial barriers shape long-term immunological health. Advancing our understanding of these processes is essential for developing novel preventive and therapeutic interventions. © M Oeggerli (Micronaut) 2022, supported by UHB (Pathology) and Bio-EM Lab, Biozentrum, University Basel. The March issue opens with the EAACI guidelines by Haahtela, O´Mahony, Traidl-Hoffmann et al., presenting the first EAACI recommendations on the significance of urban green spaces for immune health. Ha et al. provide a comprehensive review of the negative impact of wildfire smoke on atopic diseases and its effect on specific communities. Augustin et al. review our current knowledge on the impact of climate change and air quality on pollen allergies. Radauer et al., in their EAACI Task Force Report, summarize data on new allergens approved by the WHO/IUIS Allergen Nomenclature Sub-Committee between 2021 and 2024 and discuss recent developments in molecular allergy research. Hartiala et al. describe the most important indoor air determinants affecting health, and present the IDEAL cluster, which comprises seven EU-funded scientific projects on the topic of indoor air quality and human health. Perez-Garcia et al. evaluate the association between the nasal microbiome and air pollutants, meteorological conditions, and respiratory health in adolescents. Shibata et al. examine the association between airway microbiota and host DNA methylation in infants with severe bronchiolitis. Karaguzel et al. assess lung function in users of heat-not-burn tobacco and conventional cigarettes and investigate the molecular mechanisms of exposure to heat-not-burn tobacco products using animal and in vitro models. Chiang et al. identify links between per- and polyfluoroalkyl substances (PFAS) and sinonasal symptoms, providing population-based epidemiological evidence on their toxicological effects. Meng et al. examine the bidirectional association between seborrheic dermatitis and dermatologic, gastrointestinal, respiratory, and ocular epithelial barrier diseases using a large US administrative claims database. Leo et al. study the role of neurogenic inflammation mediator endothelin-1 in skin barrier impairment. Pat, Yazici and Babayev et al. investigate the effects of postbiotic strains, Bifidobacterium breve, Limosilactobacillus reuteri, and Ligilactobacillus salivarius, on skin barrier integrity and inflammatory responses using an ex vivo human skin model. Pat et al. assess the effect of aspartame on the biology, inflammation and epithelial barrier of gut epithelial cells. Leonardi et al. study the ocular microbiome in dupilumab-induced ocular surface disease. Miyake et al. identify phenotype-specific and shared gut microbial signatures in children with allergic rhinitis, including reduced diversity, loss of beneficial taxa, and altered short-chain fatty acids and immune-related pathways. Bakirtas et al. present a survey on environmental protective and risk factors and awareness related to epithelial barrier integrity, microbiome and allergic diseases. journalallergy.com

Allergy provides the readers with 19 free and open access articles in the March issue! Check out the articles and download freely with one click on the doi link. 1. Haahtela, T., O'Mahony, L., Traidl-Hoffmann, C., et al., EAACI Guidelines on the Importance of Green Space in Urban Environments for Allergy and Asthma Prevention. Allergy, 81: 635-650. doi.org/10.1111/all.70… 2. Ha, A., Balmes, J.R. and Wei, M.L. Wildfires and Atopic Diseases: A Review. Allergy, 81: 651-662. doi.org/10.1111/all.70… 3. Augustin, J., Gilge, S., Appel, H., et al., Climate Change, Air Quality, and Pollen Allergies—State of the Art and Recommendations for Research and Public Health. Allergy, 81: 663-683. doi.org/10.1111/all.70… 4. Radauer, C., Gadermaier, G., Goodman, R.E., et al., New Allergens Approved by the WHO/IUIS Allergen Nomenclature Sub-Committee in 2021–2024 and Their Significance for Future Diagnostics, Regulation, and Research. An EAACI Task Force Report. Allergy, 81: 684-699. doi.org/10.1111/all.70… 5. Hartiala, M., Elenius, V., Pesquera, A.A., et al., Exposures in Indoor Air Affecting Health. Allergy, 81: 700-719. doi.org/10.1111/all.70… 6. Teufelberger, A.R., Költgen, C., Babina, M. and Wolf, P. Prolonged IL-33 Exposure Switches the Secreted Mast Cell Cytokine Profile From Pro-Inflammatory to Pro-Tolerant. Allergy, 81: 720-733. doi.org/10.1111/all.70… 7. Nolasco, S., Fagone, E., Campisi, R., et al., Effect of the Arg16Gly β2-Adrenergic Receptor Polymorphism on Long-Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype-Stratified, Multicenter Study. Allergy, 81: 734-749. doi.org/10.1111/all.70… 8. Perez-Garcia, J., Bozack, A.K., Rifas-Shiman, S.L., et al., The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health. Allergy, 81: 750-763. doi.org/10.1111/all.70… 9. Karaguzel, D., Walewska, A., Sarac, B.E., et al., Heat-Not-Burn Tobacco Aerosols Induce Immune Dysregulation and Barrier Disruption Comparable to Conventional Cigarettes. Allergy, 81: 781-795. doi.org/10.1111/all.70… 10. Meng, S., Berna, R., Takeshita, J., et al., Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study. Allergy, 81: 808-817. doi.org/10.1111/all.70… 11. Pat, Y., Yazici, D., Babayev, H., et al., Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation. Allergy, 81: 830-847. doi.org/10.1111/all.70… 12. Burris, A.D., Diaz, N., Meddings, J.B., et al., Secretion of Peanut Protein With IgE Crosslinking Capacity in Human Milk. Allergy, 81: 861-873. doi.org/10.1111/all.70… 13. Pat, Y., Yazici, D., Zeyneloglu, C., et al., Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame. Allergy, 81: 884-901. doi.org/10.1111/all.70… 14. Adachi, T., Watanabe, S., Kuwabara, Y., et al., Exploring Patient and Public Involvement and Engagement in Allergy Research: Cross-Disease and Cross-Stakeholder Perspectives in Japan. Allergy, 81: 902-905. doi.org/10.1111/all.70… 15. Vijendra, A., Shobnam, N., Jordan, J., et al., Biomarkers Are Consistent With Patient-Reported Allergic Sensitization in Topical Steroid Withdrawal. Allergy, 81: 906-909. doi.org/10.1111/all.70… 16. Brigger, D., Steinmann, M., Roos, N., et al., Age-Related Increase in Anaphylaxis Severity Is Associated With Enhanced Sensitivity to Allergic Mediators. Allergy, 81: 910-913. doi.org/10.1111/all.70… 17. Leonardi, A., Frizzo, R., Cavarzeran, F., Ozkan, J. and Rosani, U. (2026), Ocular Microbiome in Dupilumab-Induced Ocular Surface Disease. Allergy, 81: 917-919. doi.org/10.1111/all.70… 18. Miyake, K., Watanabe, D., Otawa, S., et al., Gut Microbiome Alterations by Allergen Sensitisation and Symptom Severity in Paediatric Allergic Rhinitis. Allergy, 81: 925-929. doi.org/10.1111/all.70… 19. Bakirtas, A., Kiykim, A., Baskin, A.K., et al., A Survey on Environmental Protective and Risk Factors and Awareness Related to Epithelial Barrier Integrity, Microbiome and Allergic Diseases. Allergy, 81: 930-933. doi.org/10.1111/all.70… #Allergy_journal Read all recent papers published in #Allergy here: journalallergy.com

We’re honored that @AllergyEaaci selected our work on the nasal microbiome, environmental exposures, and respiratory health as one Editor-in-Chief’s choices of this March Issue about #Environment, #Microbiome, and #EpithelialBarrier🦠 Don’t miss it! onlinelibrary.wiley.com/doi/10.1111/al… ⬇️⬇️

📣Don’t miss the next @ATS_GG Journal Club where Dr. Rosser will present her paper in @AnnalsATS about a TWAS of PM2.5 in youth with asthma. We’re honored to have Drs. @JuanCCeledonMD, @cardenaasca & Max Seibold as panelists @atscommunity Register here ⬇️ site.thoracic.org/events/sgg-jou…

Esta semana seguiremos la pista genética🧬de las cabras para descubrir🐐la llegada de los primeros aborígenes a las islas. Hablaremos con Rosa Fregel y Clara Díaz Pérez, investigadoras del área de genética @ULL 🗓️6 de diciembre ⏰12:30 h 📻Radio5 @RTVECanarias

XIX Jornadas de Genética ULL. Este año serán el 29 de diciembre. Aula 1 Sección de Biología te dejo por aquí el cartel con referencia de las charlas de este año. Te esperamos @CienciaULL @ULL @PaleogenomicULL @Gesalud_ULL

📅 This Week in #Allergy 📚 Missed our latest content? Here's your weekend catch-up: 1. Open Access: The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health. Corresponding authors : Javier Perez-Garcia, Andres Cardenas. Read the article here: doi.org/10.1111/all.70… 2. Open Access: Basophils in Skin-Mediated Sensitization Drive Subsequent Lung Inflammation in Airway-Challenged Mice. E Da Choi, David Voehringer, Daniel Radtke. Read the article here: doi.org/10.1111/all.70… 3. The Sting Challenge Test: An EAACI Position Paper on Hymenoptera Venom Allergy. First author: Arantza Vega Castro; corresponding author: Christine Breynaert. Read the article here: doi.org/10.1111/all.70… 4. Genistein Reduced Eosinophilic Inflammation and Remodeling by Downregulating PAI-1 and TSLP. First author: Jung Yeon Han; corresponding author: Seong H. Cho. Read the article here: doi.org/10.1111/all.70… #Allergy_journal #AllergyResearch journalallergy.com

Open Access: The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health. Corresponding authors : Javier Perez-Garcia, Andres Cardenas Read the article here: doi.org/10.1111/all.70… This study evaluates the association of the nasal microbiome with air pollutants, meteorological conditions, and respiratory health in adolescents. Bacterial diversity is positively associated with hay fever and short-term NO2 exposure, and negatively with temperature. A Moraxella-dominated nasotype is linked to lower O3 exposure and higher temperature and humidity, whereas a Staphylococcus-dominated nasotype is associated with increased risk of aeroallergen sensitization. Staphylococcus, Corynebacterium, Pelomonas, Lactococcus, Lachnospiraceae (unclassified), and Faecalibacterium abundance are associated with both environmental exposures and respiratory traits. #Allergy_journal Read more articles published in #Allergy on the #microbiome here: journalallergy.com/barrier-and-mi…

Great time presenting at the 8th Annual Maternal and Childhood Health Research Institute #MCHRI Symposium @StanfordMCHRI Huge thanks to the organization for awarding our poster an honorable mention! ⭐️🧬 @StanfordEpiNews

Thanks so much to my supervisor @cardenaasca, all the team, collaborators, Project Viva participants, and funders!

📣📣Our new publication is out! By analyzing >400 adolescents from Project Viva, we associated the nasal microbiome diversity, composition, and nasotypes with air pollution, temperature, humidity, greenness and multiple respiratory outcomes 🫁🧬🦠🏭 ⬇️⬇️ onlinelibrary.wiley.com/doi/10.1111/al…

Happy to share my lab's latest research on investigating the host epigenetic and immune responses to airway microbiome exposure, led by stellar post-doc Dr. Shibata! Thanks to @AllergyEaaci editors and reviewers for their valuable suggestions! onlinelibrary.wiley.com/doi/10.1111/al…

Open Access: Multi-Ancestry Epigenome-Wide Association Study of Asthma Exacerbations. First author: Elena Martin-Gonzalez; corresponding author: Maria Pino-Yanes Read the article here: doi.org/10.1111/all.70… Martin-Gonzalez et al. performed an epigenome-wide association study (EWAS) of asthma exacerbations in Latino and African American populations from the United States. Watch the video abstract here: youtu.be/Lwnoy5BNCV0 #Allergy_journal Read more articles published in #Allergy on #asthma here: journalallergy.com/Asthma-Lower-A…

Delighted to be at #ERS2025, thank you very much for the opportunity @SeparRespira ! 🫁 As a proud ambassador, I warmly recommend not missing tomorrow’s session on Archivos de Bronconeumología at 15:00 in the Auditorium!

🚨 New publication alert! 🧬 Our multi-ancestry epigenome-wide association study of asthma exacerbations is now available in Allergy! 👉🏼 doi.org/10.1111/all.70… ✨ We extend our sincere thanks to all collaborating authors and institutions involved in this work!

I had a great time at the #ISESISEE2025 in Atlanta! First time attending this conference and I had a fantastic experience! So excited to connect with so many people in this great community and share my recent work on the nasal #microbiome and #airpollution! 🦠📊

@hellofuture100 @ERSpublications @EuroRespSoc Thank you so much, @hellofuture100! 😊

@Javier_pg96 @ERSpublications @EuroRespSoc Great work, congrats!

📣Don’t miss my the first paper of my postdoc out in ERJ @ERSpublications @EuroRespSoc! By analyzing the NHANES cohort, we observed greater epigenetic age acceleration in adults with chronic respiratory diseases, such as #COPD, #asthma and #wheezing 🫁🧬⏰ bit.ly/3SpNdHK

Thanks so much to all collaborators, funders, and NHANES contributors and participants! @SaraOccEpi @MaryRice_LungDr @drehkopf @cardenaasca @StanfordMed @StanfordEpiNews