John P. Coetzee

This #RareDiseaseDay we’re highlighting how open data sharing supports diagnosis, research & families living with rare conditions. Watch to find out how access to rare disease data can help families better understand their children’s rare conditions @Unique_charity @GeneticAll_UK

it was great to be part of this effort! psychedelics are linked to increased spirituality in vets but no change in religious affiliation (i.e., christians stayed christian). psychedelics also shifted some beliefs, e.g., inclining vets towards perennialism researchsquare.com/article/rs-896…

@ThosVarley ... but there is not firm evidence to date. Regarding other psychedelics, hard to say, given the unique receptor profile of ibogaine, but possible. More study needed.

@ThosVarley Thank you for the question, Thomas. The primary reason for administering magnesium with the ibogaine is to counteract the potential cardiac risks of ibogaine, but it. It is biologically plausible that magnesium enhances the neuroplastic effects of ibogaine —

So excited to finally see this published. We found that magnesium-ibogaine therapy was associated with increased cortical thickness, subcortical expansion, and reduced brain age. Initiated and led by the late Nolan Williams. doi.org/10.1016/j.isci…

New finding from Lena Kozyr et al "The simple metric of low Min-HR predicted better TMS response across stimulation protocols (10Hz and 1Hz TMS) in TDBRAIN+ and accelerated intermittent theta-burst stimulation in the SAINT-SNT replication samples." sciencedirect.com/science/articl…

Low heart-rate as a predictor for TMS response: Sometimes the simpler metric is better than the more complex metrics: No effects of complexity/non-linear HRV measures, but low heart-rate robustly predicts better response to TMS (HF and LF TMS), replicated in SAINT iTBS sample. Congrats Lena Kozyr and team with this publication! Complexity or simplicity? A replication analysis of low heart rate as a predictor of TMS response in major depressive disorder: sciencedirect.com/science/articl…

"...and that persisting regional changes in metabolic activity after ibogaine treatment, particularly within paralimbic brain regions, might be related to the observed therapeutic effects of ibogaine."

Important new paper from Stanford on ibogaine & brain function. "Our results suggest that ibogaine may involve widespread reorganization of functional connections in the brain... " doi.org/10.1016/j.bpsc…

Important replication trial from earlier this year of the efficacy levels observed in Stanford Neuromodulation Therapy for treatment resistant depression in prior studies from 2020 and 2022. Also a potential EEG biomarker. Congrats to the authors. pubmed.ncbi.nlm.nih.gov/41536095/

@LeahLibresco Tragic.

“Moderna’s CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: ‘You cannot make a return on investment if you don’t have access to the U.S. market.’ Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.”

“What is most disturbing is not the specifics of this case but the arbitrariness and capriciousness of the process. The EU, Canada, and Australia have all accepted Moderna’s application for review.” marginalrevolution.com/marginalrevolu…

Remember the variants? And vaccines that keep changing and don’t work so well? It’s not just COVID and coronaviruses, but flu, malaria, HIV and herpes/shingles too. This happens because the pathogen is constantly mutating most of its surface coat proteins to evade our immune system — it keeps looking different. But there is an invariant element to each, and if we could only guide our immune system to see that signal in the noise, we’d have a “universal vaccine” for all variants, both known and unknown. Imagine a single flu shot that worked well every season and would also work for new variants, even scary ones like H5N1 bird flu, weaponized flu or the Spanish Flu were it to reemerge. It could end pandemics. It might even eradicate certain pathogens altogether, as we did with smallpox. This has been a holy grail in vaccine development, one that I have philanthropically supported for many years (but those engineered nanoparticle approaches failed). Meanwhile, Centivax may have figured it out. Their approach has worked beautifully in many animal species, and human trials have just begun. We will know soon because there is a quick HAI assay that can evaluate the vaccine’s breadth of efficacy. "For decades, flu vaccination has been reactive," said Sawsan Youssef, PhD, founder and Chief Science Officer of Centivax. "A universal influenza vaccine allows us to be proactive—moving from annual guesswork to predictable durable response." “Beyond its flagship universal flu program, Centivax's epitope-focusing platform is advancing a growing pipeline spanning a pan-herpes Alzheimer's preventative, a broad oncology treatment, a malaria vaccine, and a universal antivenom recently published in Cell” — News today: prnewswire.com/news-releases/… Yeah, one universal antivenom shot for all snake species. It should also work for a variety of parasites: viral, bacterial, protozoan, even fungal outbreaks for the Last of Us. One shot to end each of them. And an Alzheimer’s preventative? If we can avoid infection by herpesvirus and flu, large natural experiments suggest that this would be neuroprotective for Alzheimer's and Parkinson's. It may prove to be the most effective treatment for dementia and neurodegeneration. See x.com/FutureJurvetso… Fingers crossed that this works in the current flu trials, and then, applying it more broadly, Centivax may end the pandemic era.

Cool new paper about Parkinson's and the SCAN network. nature.com/articles/s4158…

New in @CellCellPress, the @halpernc, @bijanpesaran, and @scangos labs collaborated on a paper identifying how human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics. ➡️ spr.ly/6015hGd7f

The CA Senate passed my No Kings Act (SB 747) to allow people to sue federal agents for damages for violating their constitutional rights — the same standard that applies to local police. It’s the 1st time a US legislative body has passed such a law. We’re ending the impunity.

We've mapped the brain combining TMS single pulses with concurrent fMRI recordings ⚡🧠 for a while. To make these causal maps avail to scientists, we are publishing them per this in press manuscript at Scientific Reports : rdcu.be/e0sjn 1/x

Really happy to see the growing body of evidence behind SAINT TMS for #depression reaching a much bigger audience through this CNN story. cnn.com/2026/01/15/hea…

Replication of SAINT-aiTBS in depression in new double-blind study demonstrating even higher remission of 50% at 4-wks FU! onlinelibrary.wiley.com/doi/10.1002/wp…

Grateful to be back at #ACNP2026, supported by my Past Travel Awardee Funding! I'm a @Stanford postdoc leading trials in interventional psychiatry with #BrainStimulation & #Ketamine for depression and suicide prevention. Join our mini-panel on 01/13 and poster on 01/15! @ACNPorg

My bill, the No Kings Act, is being voted on in committee this week. It would allow you to sue federal agents if they use excessive force, illegally detain you, or violate your right to free speech. In a democracy no one is above the law, including the President & federal agents.