Jean Donet

🔍 26 RCTs (10K+ pts) show NO significant ↑ in MACE, VTE, or CV events with JAKis (tofa, upa, filgo, etc.) vs placebo in UC/CD. Dose caveats: Tofa 5mg BID slight MACE nudge; Upa 30mg VTE trend. But Deucra? Cuts VTE/CV risks by 97%! Safest rank. Reassuring for IBD docs—JAKs viable, esp low-risk pts. Full article: Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis tandfonline.com/doi/10.1080/07…

💥Worried that SQ IFX has low drug levels? You'd be wrong....@AGA_CGH @AmerGastroAssn. 🔘426 on IV -> SQ 🔘~40% on intensified IFX ⏺️ 48 wk follow up 🟢 IV trough = 8 🟢 Wk 48 SQ IFX trough = 18. SQ = higher drug level in most. Done. (also ✅ Fig 1) cghjournal.org/article/S1542-…

📣chemoprevention in inflammatory bowel disease. In the absence of RCT data➡️50 observational studies: 1.4 million patients: Anti-TNFs⬇️colorectal cancer (CRC) risk in ulcerative colitis (UC) & 5-ASAs⬇️CRC risk in UC and Crohn’s disease 👇🏽@ahkefayat @EdinUni_IGC 🙏🏽to all authors

🍎 Randomized controlled trial finds a whole food diet induces remission in children and young adults with mild to moderate #CrohnsDisease and is more tolerable than exclusive enteral nutrition. 🔗 ow.ly/Yqwj50XA7XY

🧭 #Vedolizumab promotes small-bowel and pan-enteric #healing in #CrohnsDisease 🔸PE-mucosal healing: 15.9% at week 52 🔸SB-healing: 4.5% → 18.2% 🔸Clear reductions in CRP, FCP, Lewis & Eliakim scores 🔸Well tolerated 📖 #OpenAccess 👉bit.ly/43DZNt4 @my_ueg

The IBUS Regional Workshop Module 1 Workshop in Chicago on November 4th was an incredible experience! A huge thank you to all the participants and faculty for your valuable contributions. Here’s a look back at the highlights from the workshop!💪🏼

@BowelUltrasound Great lectures and hands on experience thank you to everyone who made it happen!

Generics have saved Americans trillions of dollars, in part because their streamlined development process facilitates competition. Now, we’re bringing the same level of competition to expensive biologic drugs.

📣 We want your input! New #IBD quality indicators are open for public comment — designed to promote evidence-based, consistent care for #CrohnsDisease & #UlcerativeColitis patients. 🗓️ Comment by Nov. 29 🔗 ow.ly/YoQK50XiECr #GITwitter

🆕Pub🚨Your One stop for all things endo & SB imaging in #IBD 🔦Dx & scoring UC/CD/pouch 🔍CRC surveillance 🔍Post-op monitoring 🧰Stricture management, endo resection, fistula closure 🤖AI-innovations 👏🏽Kudos @LumirKunovsky for driving this project 🔗 doi.org/10.1016/j.bpg.…

Coming VERY soon, a Stelara biosimilar at a far better price than you ever imagined ! starjemza.com

Non-UC causes of colitis 💡 📸: NEJM

Long-term safety of vedolizumab in patients with ulcerative colitis/Crohn’s disease: A prospective observational study - Clinical Gastroenterology and Hepatology cghjournal.org/article/S1542-… @EdwardLoftus2 @PeyrinBiroulet @peter_bossuyt Includes contribution from @IbdHull

Our work on post-operative #crohns: Biopsies from the ileum, anastomosis and colon: Inflammation at the anastomosis is the same as inflammation in the colon/ileum, it is not hypoxia! should we treat? @JeanFredericCo1 @Bealoquebea @IBDimmunology academic.oup.com/ecco-jcc/advan…

#Rinvoq prescribing information has been updated to include that upadacitinib can be used without requiring anti-TNF failure if anti-TNF use is clinically inadvisable! #AIBDREGIONALS @IBD_FloMD @MRegueiroMD @KatieFalloonMD #IBD

@ibddoctor …but if TNF blockers are inadvisable

@IBDimmunology @drkeithsiau 👍

@drkeithsiau 🔴🔑Q: how does the immune system shut down? Why doesn’t inflammation continue forever? 🔴in 1995 🤷🏾 ✅Tregs ⬇️ immune responses = paradigm shift Uses? - tx autoimmunity (IBD, Celiac, AIH,…) - prevent organ rejection Converse - block Tregs = ⬆️ immunity = ICIs = cancer tx

Can anyone explain why this is worthy of the Nobel prize in medicine, and how it applies to gastroenterology?

Lamine Yamal leaves everyone in awe 🤯

📢 New global guidelines for managing #IBD in pregnancy are here. Developed by 39 experts (lead author @UmaMahadevanIBD) + 7 patient advocates, they offer evidence-based recommendations on meds, monitoring, and infant care: bit.ly/3I48nK6 #Gastroenterology

Perianal abscesses and fistulas - demystified courtesy of ⁦@my_ueg⁩ 💡