Jessica Wilcox, MD

26 posts

Jessica Wilcox, MD

Jessica Wilcox, MD

@JessicaWilcoxMD

Assistant Attending Neuro-Oncologist @sloan_kettering | Focus on CNS metastases | Views are my own

New York, NY Katılım Kasım 2020
119 Takip Edilen187 Takipçiler
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Jessica Wilcox, MD
Jessica Wilcox, MD@JessicaWilcoxMD·
We have found that patients with neurologic manifestations of #COVID19 have inflammatory cytokines in their CSF, at levels approaching that of CAR T cell neurotoxicity. What’s more, this can be detected weeks after the acute infection. Role for steroids? mskcc.org/news/msk-resea…
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Yasmin Khakoo, MD, FCNS, FAAN, FAAP (she/hers)
Yasmin Khakoo, MD, FCNS, FAAN, FAAP (she/hers)@DrYasminKhakoo·
I’m honored to take the reins in Jan 2022 from Dr. Steve Roach as Editor-in-Chief-desígnate of the journal “Pediatric Neurology”@ELSneuroscience @ElsevierConnect
Nina F. Schor@schor_n

Congratulations to Dr. Yasmin Khakoo, the Editor-in-Chief-designate of the journal "Pediatric Neurology"! This important print voice of our field is in outstanding hands! Thanks to current Editor, Dr. Steve Roach, for many years of exceptional leadership!

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Jessica Wilcox, MD
Jessica Wilcox, MD@JessicaWilcoxMD·
@YochaiReemMD Good question! I suspect the CSF cytokine elevation is more closely linked to systemic CRS severity than to cancer, based on our matched CoV- controls. Selecting for milder patients and smaller cytokine panels (we used a 92-marker assay) might also explain reporting differences.
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Jessica Wilcox, MD
Jessica Wilcox, MD@JessicaWilcoxMD·
We have found that patients with neurologic manifestations of #COVID19 have inflammatory cytokines in their CSF, at levels approaching that of CAR T cell neurotoxicity. What’s more, this can be detected weeks after the acute infection. Role for steroids? mskcc.org/news/msk-resea…
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Jessica Wilcox, MD
Jessica Wilcox, MD@JessicaWilcoxMD·
@winstoncb Unclear. Drawing from our experience managing CAR T cell neurotoxicity, tocilizumab (an IL-6 receptor blocker) improves systemic cytokine release but does NOT improve neurotoxicity; in fact it worsens neurologic outcomes. Most biologics also don't cross the blood brain barrier.
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Hannah Davis
Hannah Davis@ahandvanish·
@JessicaWilcoxMD Thank you! Is it fair to say then that the journalists calling it “brain fog” were editorializing a bit - you were looking at a handful of more concrete conditions?
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Hannah Davis
Hannah Davis@ahandvanish·
Interesting - Memorial Sloan found a possible mechanism for the brain fog in hospitalized COVID patients. @JessicaWilcoxMD two questions, if you don't mind - was this for brain fog or delirium specifically? also - any plans to test this on non-hospitalized #LongCOVID patients?
Jessica Wilcox, MD@JessicaWilcoxMD

We have found that patients with neurologic manifestations of #COVID19 have inflammatory cytokines in their CSF, at levels approaching that of CAR T cell neurotoxicity. What’s more, this can be detected weeks after the acute infection. Role for steroids? mskcc.org/news/msk-resea…

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Jessica Wilcox, MD
Jessica Wilcox, MD@JessicaWilcoxMD·
@ahandvanish All had at least a mild dysexecutive syndrome or "brain fog." A subset experienced additional specific neurologic symptoms: severe prolonged delirium following intubation, limbic encephalitis, headaches, seizures, etc.
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Jessica Wilcox, MD retweetledi
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center@MSKCancerCenter·
It's International #WomenInSTEM Day! RT and join us as we celebrate and give a virtual high-five 🖐 to our incredible female scientists, researchers, doctors, nurses, and staff, who work tirelessly every day to further cancer research, care, and education. #WomenInScience
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Dr. Shadowgazer
Dr. Shadowgazer@DShadowgazer·
what is one word/topic in medicine people say all the time without understanding it
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@JNeurooncol @Dr_N_Moss @sammi_brown8 @MSKBiostats @MSKNeurosurgery @MSK_RadOnc @DrYasminKhakoo @ElsevierConnect