Jillian McRae-Hicks
3.6K posts

Jillian McRae-Hicks
@JillianYCS
Wife, mother, grandma, school teacher & interventionist. Values enthusiasm, personal growth & wellness. Canadian hockey & Blue Jays fan.⚾️Proud Canadian.



















Drinking beverages sweetened with the zero-calorie sweetener sucralose may significantly alter brain mechanisms involved in hunger regulation, according to a new brain imaging study. Acute consumption of sucralose increased hypothalamic blood flow by 7.9% compared to sugar-sweetened drinks (sucrose) and by 7.8% compared to water. Increased hypothalamic blood flow is a neural marker typically associated with greater hunger, and indeed, hunger ratings were significantly higher after consuming sucralose. In contrast to sucralose—which was metabolically inert due to its lack of calories—sucrose (table sugar) raised blood glucose, insulin, and GLP-1 levels, all metabolic changes that corresponded with reduced hunger and decreased hypothalamic activity. While this study investigated acute effects rather than long-term outcomes, these results underscore that non-caloric sweeteners like sucralose could disrupt the body's natural appetite control mechanisms, challenging the assumption that they represent a neutral or beneficial alternative to sugar. DOI: 10.1038/s42255-025-01227-8













