Jonathan F. Khan

Wondering if a certain academic center on the UES would consider something similar

Last but not least, thanks to Renier and Charlie for mentorship and support, and to the rest of the team for their hard work!

Using xenograft models, we demonstate that this strategy is similarly efficacious in the context of human disease, and that combination with PD-1 targeting checkpoint blockade further augments antitumor efficacy. jci.org/articles/view/…

Happy to see this story wrapped up and published! Spearheaded by my colleague and friend Janneke, we demonstrate a method to improve CAR T cell efficacy in the context of SCLC. jci.org/articles/view/…

Is all T cell failure a result of exhaustion? In this new paper, we demonstrate that chronic stimulation of CARs containing 41BB drives a novel state of T cell dysfunction that is phenotypically, transcriptionally and epigenetically distinct from classical exhaustion.

Madridista…..proofreading what i type on my phone is not within my capabilities 🤦🏽‍♂️

When your lab mate is a Madrisista 🤦🏽‍♂️

I think l NYC would agree with this as well

Nature research paper: TET2 guards against unchecked BATF3-induced CAR T cell expansion go.nature.com/3JVvSDM

Initial phase 1 results suggest that off-the-shelf #allogeneic anti-#BCMA #CAR_T cells are safe and feasible for patients with relapsed or refractory multiple #myeloma. #mmsm @MSKCancerCenter @MSK_DeptOfMed #MultipleMyeloma #NMEDClinical #Oncology nature.com/articles/s4159…

It’s true—dolphins were spotted in the Bronx River this week! This is great news—it shows that the decades-long effort to restore the river as a healthy habitat is working. We believe these dolphins naturally found their way to the river in search of fish. (Video: Nick Banco)

For the immuno crowd: the loaf was subjected to excessive costimulation which led to a dysfunctional phenotype

Me: what a total failure . . . 5 mins later: using my PhD training to identify what happened, how it happened, and noting the effects of excessive leavening agent on loaf structure.

In a new Review @AndrewChowMDPhD @KarloPerica @KlebanoffLab & @wolchokj discuss the immunobiology and clinical implications of T cell exhaustion for cancer immunotherapy: nature.com/articles/s4157… @MSKCancerCenter @WeillCornell

Science with a view of the city

@ESmithMDPhD Congrats Eric, great story!

Our report of first-in-human GPRC5D-targeted CAR T cells for MM is out in NEJM! The trial was led by Sham Mailankody and could not be done without the amazing clinical, correlative science, stats, & cell manufacturing teams. Happy to share our bench>bedside journey 1/10