Jonathan Silverberg, MD, PhD, MPH

156 posts

Jonathan Silverberg, MD, PhD, MPH

Jonathan Silverberg, MD, PhD, MPH

@JonathanMd

Dr. Silverberg is a Professor of Dermatology at the George Washington University School of Medicine and Health Sciences

Katılım Ocak 2019
53 Takip Edilen418 Takipçiler
Jonathan Silverberg, MD, PhD, MPH retweetledi
Revolutionizing AD
Revolutionizing AD@RevAtopicDerm·
You’re invited to the December virtual update on Revolutionizing Atopic Dermatitis! Get ready for CME/CE with practical patient-centered conversations and presentations on late-breaking research. Join us on December 8: bit.ly/3Z1YMaW @JonathanMd , @RajMDPhD
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Jonathan Silverberg, MD, PhD, MPH retweetledi
@derm_ce
@derm_ce@derm_ce·
31) There is growing evidence that JAK inhibitors are efficacious in #atopic_dermatitis, #alopecia_areata, #psoriasis, & #vitiligo. Additional evidence suggests that JAK inhibition may be broadly useful in dermatology, with early reports of efficacy in several other conditions.
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Jonathan Silverberg, MD, PhD, MPH retweetledi
@derm_ce
@derm_ce@derm_ce·
25b) Significant itch reductions versus vehicle were reported within 12 hours of first application of 1.5% RUX (P < .05). Application site reactions were infrequent (<1%) and lower with RUX versus vehicle; none were clinically significant.
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Jonathan Silverberg, MD, PhD, MPH retweetledi
@derm_ce
@derm_ce@derm_ce·
24a) Indeed, there are 2⃣: Topical #Ruxolitinib Evaluation in #Atopic_Dermatitis Study 1 (NCT03745638) & Study 2 (NCT03745651) #TRuE_AD enrolled patients aged ≥12 yrs with AD for ≥2 yrs, an Investigator's Global Assessment score of 2/3, and 3%-20% affected body surface area.
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Jonathan Silverberg, MD, PhD, MPH retweetledi
@derm_ce
@derm_ce@derm_ce·
9) The #JAK-#STAT signaling pathway mediates effects of several key #cytokines on immune cells, keratinocytes, and peripheral sensory neurons that lead to inflammation and itch, including IL-4, IL-5, IL-13, IL31, IL-22, and TSLP See pubmed.ncbi.nlm.nih.gov/34437922/.
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