Jonny Crebbin

@jet2tweets shocking Jet2 service again. 90% of our flights have been delayed this year. Over an hour delay and now they say the plane is too heavy and we will have to refuel at Thessaloniki. What a joke!

Nice work @AvantiWestCoast Once again the weekly and now weekend delays are consistently appalling. How on earth do you do such a shocking job!

Once again. Train delayed 0844am 17mins for Stockport to London Euston. Also premium standard coach heating didnt work so declassified! @AvantiWestCoast Embarrassingly and consistently dreadful service

And yet again more cancellations and delays by @AvantiWestCoast 0:844 for Stockport for London - CANCELLED. And then on the same day the 20:13 return delayed 15 mins! Appalling service every week! Even your staff are embarrassed!

Train delayed again this evening .@AvantiWestCoast Euston to Stockport. Delayed over 80% of the time on a weekly basis. What a dreadful service!!!

And again. Cancelled train. Every week!. @AvantiWestCoast

Nice work @AvantiWestCoast - delayed train again. This is the norm these days.

Once again… usual weekly delays on @AvantiWestCoast trains. 18:13 from London Euston. Over 30 mins late! How can you get it so wrong!

@AvantiWestCoast 7:44am Stockport and then the 10:30am on the Friday returning from Euston.

@JonnyCrebbin Which service were you trying to take, Jonny? - Mike

Once again @AvantiWestCoast cancel the Manchester to Euston train at the last minute. Disgraceful service week in week.

Shocking customer service from @Apple #Apple. Bought a pair of Beats only 4m’s ago. No longer working correctly. Apple warranty will not cover-claiming the goods were fine when they were shipped and therefore the defect is not their responsibility to fix. 15 yrs Apple customer!

@H3L3N_EJ @CaPP3 Any tips on daily dose? 30mg for Inulin?

@CaPP3 Are inulin-rich alliums also good? How much aspirin? Beyond LS can findings be generalised to gen pop? 🙏

Hi. CAPP2 tested aspirin and resistant starch in just under 1000 people with LS. Our primary endpoint was colorectal cancer. Aspirin cut the risk by 50% but RS had no effect. Our secondary endpoint was the other LS cancers. Aspirin had some effect. RS prevented 60%

@CaPP3 All this is so positive! Any guidance on daily dose of Inulin ?

Inulin is a polysaccharide resistant to digestion in the upper gut so it’s likely to have a similar effect to the resistant starch used in CAPP2. We are testing different doses of aspirin in CaPP3 to see if a smaller dose works as well as the 2 tablets a day in the CAPP2 trial.

@CaPP3 Thanks so much! This is great to hear. 11 years cancer free. Aspirin taken everyday for 10 years. #Capp3

@CaPP3 Any advice on what to have for Resisitant Starch? Is there a supplement ?

@JingPeng123 @CAPR_AACR @CaPP3 @NclUni_IHS But not other LS cancers? I always thought it helped reduce other LS related cancer occurrences too!

@JonnyCDell @CAPR_AACR @CaPP3 @NclUni_IHS Aspirin does reduce colorectal cancer risk in LS, which was reported by other studies earlier.

Online First— #CancerPrevention with Resistant Starch in #LynchSyndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up, by Mathers et al. bit.ly/3z9qMwt @NclUni_IHS

@JingPeng123 @CAPR_AACR @CaPP3 @NclUni_IHS So…Aspirin does not reduce colerectal cancer risk in LS?

@JonnyCDell @CAPR_AACR @CaPP3 @NclUni_IHS It was shown before that aspirin prevented colorectal cancer in patients with LS. This study focused on resistant starch (RS). The results showed that RS was protective against LS-related non–colorectal cancers (hard to detect and manage), although not colorectal cancer.

@CaPP3 Tried to read but slightly too technical to understand for me. Assume it’s positive! :-) Been 5 years on Aspirin on and after CaPP

Sadly too much BBC news today so CAPP2 is off the TODAY list sadly but the paper is out in Cancer Prevention Research

@RealMattLucas What a beautiful rendition.

good morning