Jørgen B

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

“Action produces information. Just keep doing stuff.” — Brian Armstrong

Grok 4 is the first AI that actually thinks from first principles about controversial subjects as opposed to the canned woke responses we’re used to now. I expect they will come under intense political pressure soon, but I hope they don’t nerf it.

Grok 4 may be doing well on some metrics but after an hour or so of testing my conclusion is that is overfitting. Grok4 is behind o3 and Gemini 2.5 in reasoning & well behind either of those models or o4 in writing quality. But great to see competition!

If you watch one thing today, make it this interview from last night in which the former head of M16 explains that Trump is a moron, that Europe must get hugely armed and fast because Russians are coming.