Journal of Experimental & Clinical Cancer Research

Online!💐 Rewiring tumor #cytokine networks to enhance #immunecheckpointblockade: mechanisms, engineering, and clinical translation Full study👇 link.springer.com/article/10.118… #TumorMicroenvironment #OncolyticViruses

New!📲 Uncovering a novel treatment strategy: #sodiumbutyrate overcomes #cisplatinresistance in the #oralsquamouscellcarcinoma by inducing #ferroptosis Open access🔓 link.springer.com/article/10.118…

New!📲 Biopsy RNA-seq captures #TROP-2–linked migration and clonal resistance to forecast aggressiveness in #metastaticmelanoma Full text👇 link.springer.com/article/10.118… #Dormancy #RNAseq #Biomarkers #Immunotherapy

Just Published🎯 Meeting Report - 7th Workshop at Regina Elena National Cancer Institute 👇 𝐂𝐡𝐚𝐥𝐥𝐞𝐧𝐠𝐞𝐬 𝐚𝐧𝐝 𝐚𝐝𝐯𝐚𝐧𝐜𝐞𝐬 𝐢𝐧 #𝐝𝐫𝐮𝐠𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞 𝐚𝐧𝐝 𝐭𝐨𝐥𝐞𝐫𝐚𝐧𝐜𝐞 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 link.springer.com/article/10.118… #PrecisionOncology #Immunotherapy

New!🍿 Targeting of a novel interplay between MET tyrosine kinase and NRF2 enhances sensitivity to #Paclitaxel in #triplenegativebreastcancer Full text⏬ link.springer.com/article/10.118… #TyrosineKinaseInhibitors #DrugResistance #PatientDerivedOrganoids

New study!🧋 #Prosaposin orchestrates a TGFβ1-driven paracrine loop between #Schwanncells and #gastriccancer to accelerate #perineuralinvasion For free🔓 link.springer.com/article/10.118…

Online!🍩 #Paroxetine repurposing enhances #antitumorimmunity via SPOP-mediated PD-L1 #ubiquitination and proteasomal degradation Read here📲 link.springer.com/article/10.118… #ProgrammedCellDeathLigand1 #Immunotherapy #DrugRepurposing

New!💐 A mitochondrion–targeted natural polyphenolic copper carrier overcomes tumor resistance to cisplatin by potentiating #cuproptosis Full text🔽 link.springer.com/article/10.118… #DrugResistance #Glutathione #MitochondrialCopper

Just published!🍹 Tertiary lymphoid structures in the era of cancer therapy Look here📥 link.springer.com/article/10.118… #TertiaryLymphoidStructures #TumorMicroenvironment #Immunotherapy #Spatialmultiomics @NisticoLab

Online!🌍 Impairment of #oxidativemetabolism compromises Rad51 recruitment and potentiates #PARPinhibitor effectiveness in #ovariancancer Look here👇 link.springer.com/article/10.118… #Mitochondria #HomologousRecombination #DNArepair

New!🩸 Reconstructing the metastatic journey: functional #circulatingtumorcells and disseminated tumor cells based models for #translationaloncology Open access📲 link.springer.com/article/10.118… #PDXmodels #LiquidBiopsy #Metastasis

#WorldCancerDay #UnitedbyUnique #CancerJournal 🌍🔬🧪 @IREISGufficiale

Now online!👏 Targeting #NOTCH3 to eradicate dormant and therapy-resistant #multiplemyeloma cells Full text 📲 link.springer.com/article/10.118… #NotchSignaling #Dormancy #Bortezomib #DrugResistance

New!📲 #Neutrophil-macrophage crosstalk via NETs–IL-17/VEGF/S100A9 axis promotes #hepatocellularcarcinoma progression For free🧐 link.springer.com/article/10.118… #NeutrophilExtracellularTrap #Macrophage

New!🍸 Immunological and molecular insights into acinar-ductal #metaplasia and atypical flat lesions as precursor lesions of #pancreaticductaladenocarcinoma Full text👇 link.springer.com/article/10.118… #TumorMicroenvironment #GeneticAlterations

Published on JECCR!🍩 TCF3 activates #superenhancer-driven TRIB2 overexpression to suppress #ferroptosis and promote #hepatoblastoma proliferation Open access🔓 link.springer.com/article/10.118… #Epigenetics #ReactiveOxygenSpecies

New!⚡️ Inhibition of RACGAP1 sensitizes #triplenegativebreastcancer cells to #ferroptosis by regulating CPT1A-dependent fatty acid metabolism Full study📲 link.springer.com/article/10.118… #FattyAcidOxidation #LipidPeroxidation

Online!🤳 FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of #chemotherapy agents in #BreastCancerAwareness For free🪂 jeccr.biomedcentral.com/articles/10.11… #Doxorubicin #CytoskeletonRegulation

Online!🦋 Single-cell insights into #tumormicroenvironment heterogeneity and plasticity: transforming precision therapy in #gastrointestinal cancers Full text👇 link.springer.com/article/10.118… #GastricCancer #TumorMicroenvironment #CancerAssociatedFibroblasts

Online! 🧠 SGSS05-NS3, a covalent SETD8 inhibitor that activates #p53 pathway in #neuroblastoma Full text 💻 link.springer.com/article/10.118… #Topotecan #PediatricTumor #MYCN