JuanCa
1K posts




🚨 BREAKING: José Mourinho back to Real Madrid, HERE WE GO! 💣🤍 All terms have been verbally agreed between José Mourinho and Real Madrid, waiting to sign all documents. Plan for initial two year deal, JM to travel to Madrid after Real-Bilbao game. The Special One is back.





⭐ Targeting heterogeneity in metastatic prostate cancer — PART 2 🔬 @OncoAlert @APCCC_Lugano #IPCS26 #APCCC26 @Silke_Gillessen @AOmlin Presented by Peter S. Nelson 🔹 Key messages: 🔹 1. Prostate cancer evolves across multiple lineages under treatment pressure → beyond AR-driven disease. 🔹 2. Lineage plasticity creates diverse phenotypes with distinct therapeutic vulnerabilities. 🔹 3. Building dependency maps (CRISPR, RNAi, drug screens) is key to identifying actionable targets. 🔹 4. New prostate cancer models (PDX → 2D lines) enable systematic study of tumor dependencies. 🔹 5. Patient-derived models capture tumor evolution from primary tumor to recurrence and metastasis. 🔹 6. These platforms allow linking genotype → phenotype → therapeutic sensitivity. 🔹 7. Precision oncology will depend on targeting lineage-specific dependencies. @_ShankarSiva @AmandaNizamMD @tompowles1 @brian_rini #ProstateCancer #UroOncology #Oncology








Creer para sentirse vivo.














