Justin Pritchard

This is an interesting idea: turning a cancer's drug resistance against it These are growth curves of tumours in mice, treated with a drug (a tyrosine kinase inhibitor). The tumours initially shrink but they all - slowly but surely - become resistant: This study aimed to convert this resistance into vulnerability, by supplying tumours with a plasmid that deliberately provides resistance to the drug - but also encodes a suicide gene What this means is that tumours shrink initially as they're treated with the tyrosine kinase inhibitor, but then grow back - fast - as they start to express the resistance gene This expands the pool of resistant cells, but also the pool of cells with the suicide gene - so when the suicide gene is switched on (purple arrow), the tumours regress: Leighow et al: nature.com/articles/s4158…

Additionally, we find that our platform can effectively redesign tumors in vivo, enabling the elimination of cancers otherwise destined for treatment failure.

As our understanding of the molecular basis of cancer improves, so does our ability to build targeted drugs that exploit cancer's genetic vulnerabilities to safely and potently kill tumor cells.

@kristen_naegle @UVADeanJWest @UVABME Congrats Kristen!!!!!!!!!

Astronomer Cecilia Payne-Gaposchkin missed out on recognition despite her brilliance; a 2020 biography sets her in the firmament. go.nature.com/3st4PFm

@NiTriona Thanks ! We are excited about these gene sets, and are using them a lot in our lab now. I’m getting a tweetorial together!

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments | Nature Communications . Congratulations ⁦@JustinPritcha19⁩ nature.com/articles/s4146…

Good exposition of Bayes’ law applied to high false positive rate in genetic testing for rare diseases nytimes.com/2022/01/01/ups…

Our paper on mechanical stress-induced tumor cell migration and proteomic analysis (p38MAPK/JNK/cdc42/Rac1 axis) with @TriantafyllosS4 lab and Gordon Mills lab has been published on @MCR_AACR. Open access here: doi.org/10.1158/1541-7… Wonderful work by Maria and Rosy.

Congratulations to Manu Platt @DrPlattLab — a new @BMESociety fellow & member of the board of directors. Not to mention co-chair of this week's #BMES2021. 🎉 bme.gatech.edu/bme/news/platt… #CoulterBME

Amen. (For all that @NateSilver538’s pandemic takes have not always been tip top terrific, this is absolutely correct)

"You can be a scientist just like you are" - @DrPlattLab in conversation w/ @wkamaubell on #UnitedShades. They talk research funding disparities, imposter syndrome & more. ICYMI, re-airs 11p on 5/22 on @CNN and is available on demand.

Congratulations to Manu Platt @DrPlattLab (@GeorgiaTechBioE @BMES) for the 2021 @aimbe Award he received yesterday. Well done, great recognition of his exceptional and pioneering efforts to improve diversity.

@Lola_UMich Thanks @Lola_UMich and to the others that came before me. Looking forward to meeting the many more coming behind us!

@peytonlab Congrats Manu! You rock!

25 years ago today, Thomas Hamilton walked into my children's school in Dunblane & shot 16 children. My colleague Mick North lost his daughter Sophie & started the Snowdrop Campaign to change the law on handguns. Death from gunshot in the UK has now fallen by 75%.⁠

Results by Jones et al show that #doxorubicin can be administered at high cumulative doses with a low rate of cardiotoxicities in patients with soft tissue sarcomas in the context of dexrazoxane co-administration. @RobinL_Jones bvantine1 #AACRrsm21 bit.ly/3qauRtL

This is a great position for someone interested in epistasis or the structure of the genotype-phenotype map! But I'm also very open to candidates with a physics, ML, oe math background looking to get into biology. Informal inquiries welcome, please e-mail or DM!

Thanks for this honor @AAASmeetings ! And the video is amazing, very touching with so many of my former students and current pridemakers! Love watching my #plattlabsquad change the world! youtu.be/K7AsYlD-9nc @CoulterBME @ibbgatech @BlkInEngineerng @GT_BioE @GT_Esteemed

So nice to see our paper in print at @BloodJournal ashpublications.org/blood/article-…

@EES_update @Mark_P_Zwart @JustinPritcha19 @JeffTownsend @joshualevipayne @PeterALind @natarajan02 @ArlinStoltzfus