VR.Krishnakumar

Hi! We are currently analyzing HLA-DQ antibodies, and our observations suggest a predominant role of the beta chain in driving immunogenicity. However, the alpha chain significantly modulates this response, and in some cases, we are seeing isolated alpha-chain–targeted epitopes contributing to DSA formation. These findings highlight the complexity of DQ heterodimer immunogenicity—both chains cannot be interpreted in isolation. Further population-based and eplet-level analyses are needed to better understand these patterns and their clinical relevance.

Fascinating insight into HLA-DQ antibodies! It's crucial to understand how they can impact graft outcomes and lead to sensitization. Have you come across any effective strategies to mitigate this risk? #TransplantImmunology #Medicine. For more in-depth information, Sci-Quest is a fantastic resource to explore these kinds of topics—check it out at sciqst.com.

*HLA-DQ Antibodies: The Silent Cracker That Starts the Blast* *************************** ⚡HLA-DQ antibodies are the most common de novo DSA ⚡HLA-DQ DSA have the worst graft outcomes (ABMR, TG, graft loss) ⚡DQ mismatch carries the highest risk of sensitization (↑cPRA) ⚡ HLA-DQ has dual polymorphism (α + β chains) ⚡Can form multiple heterodimers (cis + trans pairing) ⚡ More heterodimers → more epitopes → higher immunogenicity ⚡ HLA-DQ shows low expression but high pathogenicity ⚡ Expression is delayed but sustained → chronic rejection ⚡ DQ antibodies activate Akt / S6 / IL-6 pathways ⚡ Current matching underestimates DQ risk ⚡ Eplet/pairing-based analysis > antigen matching #KKNephBytes #Immunology @arvindcanchi @DrAkshayaJ @drshyambansal @hardik4u24 @isn_india @priti899 @suhalikapath @JJayameena

“World Kidney Day Awareness: CKD Do’s and Don’ts " #WorldKidneyday @DrAkshayaJ @worldkidneyday @arvindcanchi @drshyambansal @taruna_pahuja @KKNephBytes @YashenduSarda @isn_india

Good Diet Save your Kidney #WorldKidneyday @DrAkshayaJ @worldkidneyday @arvindcanchi @drshyambansal @taruna_pahuja @KKNephBytes @YashenduSarda @isn_india

@hardik4u24 @DrAkshayaJ @priti899 @suhalikapath @arvindcanchi Thank you @hardik4u24

@KKNephBytes @DrAkshayaJ @priti899 @suhalikapath @arvindcanchi Excellent VA summary @KKNephBytes ! Transfusion HLA abs are usually short-lived → minimal impact on future XM in most cases. Big implications for sensitized kidney waitlist patients too. #Transplantlmmunology

Transfusion-related HLA sensitization: risk factors, dynamics, and clinical relevance #KKNephBytes #TransplantImmunology @DrAkshayaJ @hardik4u24 @priti899 @suhalikapath @arvindcanchi

HLA Typing Workflow: Magnetic Separation of Required DNA Transplant Immunology Lab IQRAA international Research Centre Calicut

HLA-DQ: The Silent Architect of Chronic Alloimmunity *********************** 1⃣ DQ mismatch = major risk for chronic ABMR and late graft loss. 2️⃣ De novo DQ DSA is common and usually appears late. 3️⃣ Both DQA1 and DQB1 are polymorphic — alpha matters. 4️⃣ Heterozygous donors can form up to 4 DQ heterodimers (cis + trans). 5️⃣ More heterodimers = more epitope diversity = higher immunogenic potential. 6️⃣ High-resolution typing (DQA1 + DQB1) is essential for accurate assessment. 7️⃣ Eplet mismatch predicts risk better than antigen-level mismatch. 8️⃣ DQ antibodies are strongly linked to transplant glomerulopathy. 9️⃣ DQ DSA is often persistent and difficult to eradicate. 🔟 DQ mismatch is a key driver of long-term graft outcome. #KKNephBytes #Immunology @hardik4u24 @priti899 @DrAkshayaJ @suhalikapath @arvindcanchi

Hemodialysis explained in Malayalam for the general public and patients to understand. Listen to Kidney Konversations - A Podcast from ISN India on Spotify for Creators. open.spotify.com/episode/43ip8X… @ShreshtaT @KKNephBytes @DrSouravSarkar3 @YashenduSarda @dakidneydoc

❓🦟 When treating adult malaria, are we missing the kidney? 🦋Our systematic review shows ~1 in 4 patients develop AKI, with ~19% mortality.🔥 💥SURVIVORS may develop CKD 💥Vivax malaria is no more benign Check it out 🔗 pubmed.ncbi.nlm.nih.gov/41620769/� share.google/VJVxcYLPFPCQDK…

DREMM in Kidney Retransplantation ::::::::::::::::::::::::::::::::: ⚡Not all DSAs are equal ⚡DSA targeting repeated eplet mismatches (DREMM) = higher risk ⚡Repeated mismatch often missed at antigen level.Seen in ~87% at eplet level ⚡ABMR risk shoots up,70% with DREMM vs 28% without ⚡DREMM DSAs are strong & persistent ↑ MFI • ↑ DSA burden • ↑ 3-month persistence ⚡All death-censored graft losses occurred in DREMM patients ⚡Antigenic repeat ≠ risk DSA must target the repeated eplet ⚡Reflects memory B-cell recall from first graft 🚨Clinical pearl ⚡In retransplantation, check eplet-level DSA targets—not just HLA mismatch counts @KKNephBytes #KidneyTransplant #TransplantImmunology #DSA #Eplets #ABMR

Pre Diabetic Donors Evaluation #Renaltransplant #CKD @arvindcanchi @DrAkshayaJ @hardik4u24 @priti899 @suhalikapath

🎉We’re excited to introduce the Indian Society of Nephrology Social Media Team 2026 🎉 This passionate group of nephrologists will lead ISN’s digital outreach, sharing education, research, and conference updates with our nephrology community. ✨🗞️ Handles ⬇️ #ISN #NephTwitter

@DrAkshayaJ @thisis_drgsp @KajareeG @KKNephBytes @drshahinnephro @DrSouravSarkar3 @ShreshtaT @dakidneydoc @taruna_pahuja @YashenduSarda @arvindcanchi - Chair @drshyambansal - Advisor Do follow the team for updates, insights, and great nephrology conversations ! 😇✨

CDC and Flow Crossmatch: Signals, Noise, and Significance #Immunology #CDC @DrAkshayaJ @hardik4u24 @priti899 @suhalikapath @arvindcanchi

Where Science Listens: The HLA–Antibody Symphony at a World-Class Transplant Immunology Laboratory and Transplant Centre IQRAA International Hospital & Research Centre, Calicut, Kerala

Eplets: Where Compatibility Truly Begins ********************************* ⚡Eplets are the true targets of alloantibodies, not HLA antigens. ⚡Eplet mismatch predicts dnDSA and AMR better than antigen mismatch. ⚡HLA-DQ eplets are the most immunogenic. ⚡Not all eplets are equal—few immunodominant eplets cause most injury. ⚡Antibody-verified eplets carry highest risk. ⚡Repeated eplet mismatches → persistent, high-MFI DSA. ⚡Eplet analysis enables precision risk stratification in transplantation. #KKNephBytes #Immunology @DrAkshayaJ @hardik4u24 @priti899 @arvindcanchi @elbaonelida @dra_miliflores

Second Transplant Key Points #transplantstories #Immunology @hardik4u24 @priti899 @SnehansuDev7 @arvindcanchi @DrAkshayaJ