VR.Krishnakumar

Blood transfusion amd Alloimmunization #Transplant #Immunology #KKNephBytes @arvindcanchi @CMEINDIA1 @DrAkshayaJ @DrMedhavi_G @drshyambansal @hafeeq_benil @hardik4u24 @isn_india @myadla @priti899 @suhalikapath @ShreshtaT @JJayameena @AnjanaGopal9 @DrAnjanaAsokan @hafeeq_benil

Post transplant TMA. Key points #transplant #KKNephBytes @CMEINDIA1 @DrAkshayaJ @DrMedhavi_G @drshyambansal @hafeeq_benil @hardik4u24 @myadla @priti899 @ShreshtaT @suhalikapath, @arvindcanchi

Post transplant diarrhoea #transplant #diarrhea @arvindcanchi @CMEINDIA1 @DrAkshayaJ @DrMedhavi_G @drshyambansal @hafeeq_benil @hardik4u24 @IamGopambuj @isn_india @myadla @priti899 @suhalikapath @

TCMR with Hemorrhage Key Points #Transplant #Biopsy #KKNephBytes @arvindcanchi @CMEINDIA1 @DrAkshayaJ @DrMedhavi_G @drshyambansal @hafeeq_benil @hardik4u24 @isn_india @myadla @ShreshtaT @

@priti899 @NephroSeeker @DrAkshayaJ @DrMedhavi_G @CharuMalik_ISN @valerie_luyckx @myadla @bhushan_sree @thisis_drgsp @IamGopambuj @arvindcanchi Congtz

🌸Winning Best Research Abstract at World Congress of Nephrology — a moment I’ll truly cherish ✨🏆 Deeply grateful to International Society of Nephrology and my amazing team for being part of this journey 🙌💙

Paired Kidney Donation Guidelines okayed by the Karnataka Government. This is great news.

ABCDE frame work New Era In Kidney Health #KKNephBytes #CKD @DrAkshayaJ @drshyambansal @hafeeq_benil @hardik4u24 @isn_india @NDTsocial @priti899 @ShreshtaT @suhalikapath @JJayameena @nephromythri @arvindcanchi @CMEINDIA1 @ISNkidneycare

HLA-B15: A Hidden Story Beneath the Surface #KKNephBytes #Immunology @DrAkshayaJ @drshyambansal @hardik4u24 @isn_india @priti899 @sciqst @ShreshtaT @suhalikapath @arvindcanchi @hafeeq_benil @JJayameena

Membranous Nephropathy 🔬Anti-PLA2R = used for Diagnosis , Prognosis, Monitoring 📊 Risk stratify: Based on Proteinuria + eGFR + AntiPLA2R 🟢 Low risk→ Supportive 🟡 Mod→ Observe ± RTX 🔴 High→ Rituximab / Cyclophosphamide+Steroid 👍for Antigens: VA @KKNephBytes 💯 #KDIGO

Honoured to be a part of this amazing team !!✨🎉🗺️ Looking forward to #ISNWCN & Japan 🇯🇵 !! @ISNWCN @Alexgr23 @Glomkeeper @manishmedicine1 @Arunkr_Dr @acssjr @brammahin @NephroSeeker @dra_miliflores @Dilushiwijay @GabyNeph @HarukaM_5 @KajareeG @DrMedhavi_G @deniise_am @myadla

Dormant but Dangerous: DQ Will Return #KKNephbytes #transplant #immunology @DrAkshayaJ @drshyambansal @hardik4u24 @isn_india @ShreshtaT @priti899 @suhalikapath @arvindcanchi

"😎Glad to see our data, hitting the press! 🚀 ✔️ Driven by these findings, we’ve just kicked off an RCT 🎲 in the department comparing VKA💊 versus DOACs in NS. 💥Likely to move the needle on anticoagulation strategies in NS . share.google/XMWjELv8In2CR0… @SaynaNorouzi @AKronbichler @myadla @SwarnalathaGud2

*When Positivity Misleads: Recognizing False Signals in SAB Testing* *********************** ⚡SAB positivity can represent artefact rather than true immunologic risk ⚡High MFI alone is unreliable without pattern and clinical context ⚡A broad, tapering (“long-tail”) pattern suggests non-specific reactivity ⚡Lack of sensitization history should prompt cautious interpretation ⚡FlowPRA and FCXM discordance helps identify non-clinical antibodies ⚡Absence of a shared epitope supports non-specific binding ⚡Misinterpretation can lead to false DSA assignment and inflated cPRA ⚡Result in unnecessary exclusion of compatible donors ⚡Always interpret SAB results in integration with clinical and laboratory correlation ⚡Pattern recognition is more reliable than numerical thresholds #KKNephBytes #Immunology @arvindcanchi @DrAkshayaJ @drshyambansal @hardik4u24 @isn_india @priti899 @suhalikapath @AnjanaGopal9 @raja_1980 @dr_sourabha @iamnephrologist

Hi! We are currently analyzing HLA-DQ antibodies, and our observations suggest a predominant role of the beta chain in driving immunogenicity. However, the alpha chain significantly modulates this response, and in some cases, we are seeing isolated alpha-chain–targeted epitopes contributing to DSA formation. These findings highlight the complexity of DQ heterodimer immunogenicity—both chains cannot be interpreted in isolation. Further population-based and eplet-level analyses are needed to better understand these patterns and their clinical relevance.

Fascinating insight into HLA-DQ antibodies! It's crucial to understand how they can impact graft outcomes and lead to sensitization. Have you come across any effective strategies to mitigate this risk? #TransplantImmunology #Medicine. For more in-depth information, Sci-Quest is a fantastic resource to explore these kinds of topics—check it out at sciqst.com.

*HLA-DQ Antibodies: The Silent Cracker That Starts the Blast* *************************** ⚡HLA-DQ antibodies are the most common de novo DSA ⚡HLA-DQ DSA have the worst graft outcomes (ABMR, TG, graft loss) ⚡DQ mismatch carries the highest risk of sensitization (↑cPRA) ⚡ HLA-DQ has dual polymorphism (α + β chains) ⚡Can form multiple heterodimers (cis + trans pairing) ⚡ More heterodimers → more epitopes → higher immunogenicity ⚡ HLA-DQ shows low expression but high pathogenicity ⚡ Expression is delayed but sustained → chronic rejection ⚡ DQ antibodies activate Akt / S6 / IL-6 pathways ⚡ Current matching underestimates DQ risk ⚡ Eplet/pairing-based analysis > antigen matching #KKNephBytes #Immunology @arvindcanchi @DrAkshayaJ @drshyambansal @hardik4u24 @isn_india @priti899 @suhalikapath @JJayameena

“World Kidney Day Awareness: CKD Do’s and Don’ts " #WorldKidneyday @DrAkshayaJ @worldkidneyday @arvindcanchi @drshyambansal @taruna_pahuja @KKNephBytes @YashenduSarda @isn_india

Good Diet Save your Kidney #WorldKidneyday @DrAkshayaJ @worldkidneyday @arvindcanchi @drshyambansal @taruna_pahuja @KKNephBytes @YashenduSarda @isn_india

@hardik4u24 @DrAkshayaJ @priti899 @suhalikapath @arvindcanchi Thank you @hardik4u24

@KKNephBytes @DrAkshayaJ @priti899 @suhalikapath @arvindcanchi Excellent VA summary @KKNephBytes ! Transfusion HLA abs are usually short-lived → minimal impact on future XM in most cases. Big implications for sensitized kidney waitlist patients too. #Transplantlmmunology

Transfusion-related HLA sensitization: risk factors, dynamics, and clinical relevance #KKNephBytes #TransplantImmunology @DrAkshayaJ @hardik4u24 @priti899 @suhalikapath @arvindcanchi