Oktay I. Kaplan
270 posts
Oktay I. Kaplan
@KaplanOLab
The Kaplan lab uses C. elegans as a model system to understand the molecular basis of rare diseases & functional inference of genetic variants.
Katılım Mart 2019
337 Takip Edilen542 Takipçiler
Our collaborative work with @DimitriadiLab is now out. Thanks for having us involved. “Widespread intron retention and exon skipping characterise alternative splicing changes in a C. elegans model of spinal muscular atrophy” academic.oup.com/hmg/article/do…
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Oktay I. Kaplan retweetledi
Cranioectodermal Dysplasia (skeletal, ectodermal, renal & liver defects) is now linked to a non-IFT gene, CILK1.
#Genetics #CED #Ciliopathy #EJHG
nature.com/articles/s4143…
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Grateful to my PhD student Ferhan Yenisert for pushing the ciliome field forward
#ciliome #ciliagenes #ciliopathy #genomics #bioinformatics #ciliahub #cilia #cilium
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The result: ~10% of the human genome encodes ciliary genes. This represents a Gold Standard update of known ciliary genes. Read the preprint: biorxiv.org/content/10.110…
Explore the database: theciliahub.github.io/#/
Code: github.com/thekaplanlab/C…
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New preprint!
We all know mitochondria & lysosomes depend on thousands of genes. But what about the ciliome?
👉 How many human genes actually build and regulate cilia?
biorxiv.org/content/10.110…
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Oktay I. Kaplan retweetledi
A novel genetic cause of Cranioectodermal Dysplasia (CED) in five new cases @Abdulla97690428, @KaplanOLab
This study identifies CILK1, a non-core-IFT protein-encoding gene, as the first of its kind linked to CED.
nature.com/articles/s4143…
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Oktay I. Kaplan retweetledi
⏳ Financial Aid Application deadline approaching!
Child/dependent care support (available to all attendees) and fellowships for ECRs are available.
Don't miss your chance to join us for #mbiosys25.
📆Apply by *this Wednesday*, Apr 30!
🌎 Chile awaits — 🧬🧪🗻
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bu rennienin muadili var mı? yerli marka veya boykot olmayan marka?
Türkçe
An amazing week for me—celebrating my MSc graduation alongside the wonderful colleagues and friends who made this journey so special✨ I’ve also begun my PhD to study optogenetic vision restoration at @yourUMG 👁️. Super excited for this new chapter and what’s to come!
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Oktay I. Kaplan retweetledi
Taking about diversity, equity and inclusion. So many students miss the opportunities of their life time, through visa rejections, preventing them from attending conferences. Is this the kind of European immigration policy to recruit talents to Europe ? @ItalyinIstanbul ?
İzel Cemre Akşahin@icemreaksahin
@ItalyinIstanbul @TC_MilanoBK @ecnptweets @MehmetOzoktem Today, I found out that my visa was rejected under Article 10, even though my colleagues were able to obtain Schengen visas for the same congress. I respectfully request a reconsideration of my Cultural Visa application. #visarejection #visadeny
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@MahjoubLab @EuroCilia2024 UCD is a stunning location and the perfect venue for organizing the #Cilia2024 meeting.
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@KarenL_PhD I just finished reading the paper. Fantastic work, Karen!
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If you're interested in learning more about TMEM67 cleavage visit the poster at #Cilia24 P125-C I'm proud of my little worm contribution to this story ☺️
TheNandadasaLab@LabNandadasa
Vey excited to unveil our work identifying the TMEM67 extracellular domain cleavage site. This is the first ciliary structural protein cleavage site identified using N-terminomics and validated in humans, mice and C elegans. biorxiv.org/content/10.110…
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A couple of months ago, I had to visit the ER due to severe pain. The team acted quickly and saved my life, and I spent 6 days in the ICU
I'm on the road to recovery now, but paper revisions are delayed as part of this necessary healing process
I was away from X during this time
GIF
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Oktay I. Kaplan retweetledi
We are happy to contribute to a new paper by @KaplanOLab, which generated the Ciliogenics database for predicting novel ciliary genes. @EfeBegar used localization and loss-of-function experiments to validate new ciliary proteins in mammalian cells. @NAR_Open
Oktay I. Kaplan@KaplanOLab
Our paper "CilioGenics: an integrated method and database for predicting novel ciliary genes" is out in @NAR_Open ! academic.oup.com/nar/advance-ar… A preprint of this work was posted in April 2023.
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Our paper "CilioGenics: an integrated method and database for predicting novel ciliary genes" is out in @NAR_Open !
academic.oup.com/nar/advance-ar…
A preprint of this work was posted in April 2023.
Oktay I. Kaplan@KaplanOLab
We are very excited to share the preprint from our lab: We combined multiple datasets (scRNA-seq, comparative genomics, PPI, transcription factors based regulatory networks) for predicting novel ciliary genes
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We extend our deepest appreciation to the spirit of open and collaborative science.
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We integrated these to provide a CilioGenics score for each human gene, assessing its potential to be a ciliary gene. In the paper, we describe several newly identified ciliary genes, such as WDR54, TMEM145, ZNF474, and ZC2HC1A.
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In our study, we combined multiple datasets, including single-cell RNA sequencing (scRNA-seq) from various tissues, comparative genomics, protein-protein interactions (PPI), and transcription factor-based regulatory networks.
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