Keith O’Shaughnessy

🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv (chemrxiv.org/engage/chemrxi…) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter begins. Quick summary: Since Gomberg discovered free radicals over 120 years ago and Kochi pioneered radical cross-coupling in the 1970s, this field has surged with interest for linking C(sp3) fragments. Unlike traditional polar methods (e.g., Suzuki), radical cross-coupling excels with saturated systems, offering mild conditions and chemoselectivity to build complex molecules from common fragments. Until now, enantiospecific radical cross-coupling was deemed impossible due to rapid racemization, but today that changes with readily available sulfonylhydrazides and a simple Ni-catalyst. This stereoretentive approach, enabled by a unique Ni-diazene transition state and driven by loss of N2, skips chiral ligands and redox steps, opening new possibilities for synthesis.

*PLEASE REPOST* I’m currently finishing my PhD thesis in Synthetic Carbohydrate Chemistry & X-ray Crystallography. I am experienced in silyl protection, regioselective synthesis & complex structural elucidation. I am looking for a postdoctoral position in related areas

👀 Searching pubmed from inside my google sheet… winning!

Big thank you to @dJon_es for his wonderful talk on ‘Complexity generating dimerisation reactions’. It was a wonderful way to conclude Organic Discussions for 2023/2024! Thank you to all our speakers from the last year! Hopefully we’ll see some new and familiar faces next year!

Really enjoyed presenting a broad overview on glycotherapeutics today to some academic staff and researchers at @UCC @UCCResearch @uccchemistry today

Big thank you to @EliLillyandCo and @RoseOMahony for hosting Organic Discussions this morning! The site tour and talks from various employees were fantastic and gave everyone a great insight into the company. All of the postgrads that attended extend their gratitude! 🧪👩‍🔬👨‍🔬

Very successful start to Organic Discussions! Wonderful talks from Amy, Emily and Emma on “The life and work of Dorothy Hodgkin”, “Aldehydes and Ketones as Flavouring Agents” and “Myth Busters: Organic Discussions Edition” Our next session will take place on 16/11/2023!

PhD researchers and even post-docs showing up in solidarity in front of Cork City Hall today to protest for better PhD pay and conditions 🙌🏼 #PGRsDeserveBetter #ResearchIsWork @PWO_Ireland

This time last year government announced a pitiful €500 increase to stipends as a cost of living measure. On budget day. This year @SimonHarrisTD says we should wait til Thursday to find out what we might get. Clearly not enough of a priority to feature in #Budget2024 statement

We are disgusted to have been overlooked in #Budget2024 despite assurances from @dfheris that IRC/SFI stipends would go up. We are struggling. We are the backbone of Irish research & higher edu. We are undervalued by the state & our universities. We are fighting back - join us

@mcglackengroup @MarkPower96 @EurJOC @dJon_es @Katrina92Mackey Congrats @MarkPower96 & @mcglackengroup excellent work!

Congrats Mark! @MarkPower96 Nice work just published in @EurJOC @dJon_es @Katrina92Mackey too! Access to Electron‐Rich Dibenzofurans through NBu4OAc Mediated Palladium Catalysis - Power - European Journal of Organic Chemistry - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ej…

We're delighted to have the series of Organic Discussions for this semester culminate in an excellent site tour of ThermoFisher, Cork. Thanks to @thermofisher for this great opportunity for our postgrads and thanks to everyone who came along for the day. 🧪👩‍🔬👨‍🔬

@sbcsgalway I keep trying to submit an abstract for the colloquium, however, the past few days I keep getting an error and I’m worried as the deadline is tomorrow. See image below. Thanks

I wish you could thumbs up an email. Like I’m constantly torn between feeling rude for not replying or just sending a simple ‘thanks’ - which I feel is a waste of everybody’s time… Just me?

This ⬇️ needed to be done, and now. Thank you to @SimonHarrisTD for initiating this. Hopefully it progresses with pace. gov.ie/en/press-relea…

I just signed this petition to @SimonHarrisTD to implement a minimum stipend of €28k for all PhD researchers to match the stipends of new proposed PhD research positions. Will you join me? #FairPayForPhDResearchers my.uplift.ie/petitions/fair… via @UpliftIRL

@ZGroupUL @CGD_ACS @Shasha__Jin @BernalNews @SSPCentre @ChemicalSciUL Congrats Shasha!

Latest ionic cocrystal paper from @zgroupUL is available OA @CGD_ACS: pubs.acs.org/doi/10.1021/ac… Phenol-phenolate supramolecular synthon is relevant to potential drug substances incl natural products. Congrats to @Shasha__Jin🇨🇳 for 1st author paper #1 + co-authors Rana🇮🇷 and BQ🇨🇳

@hidear_3 Fierce, creative, confident