Kelly Chibale

1/2 #Afropessimism – a term that I often use to emphasize a critical & often ignored issue. It is sad that people don’t trust African scientific #innovation. I always say this & I repeat – as Africans, we must take pride in what is #locallyproduced & support #localproducers.

Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An In Silico and In Vitro Modeling Approach pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #MedicinalChemistry #Hypertension #CardiovascularResearch #ACEInhibitors #DrugDiscovery #ComputationalChemistry

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #MedicinalChemistry #CancerResearch #MitochondrialBiology #OncologyResearch #DrugDiscovery

Maltose-Conjugated Thiosemicarbazones from Substituted Benzaldehydes: Synthesis and Inhibitory Activity against Gram-(+) and Gram-(−) Bacteria pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #AntimicrobialResistance #AntibioticDiscovery #InfectiousDiseases #DrugDiscovery

Now an Honorary Fellow of the #RoyalSocietyofChemistry, its highest accolade. Encouraging to see recognition of science that combines excellence, leadership and societal impact. Read more: rsc.org/news/2026-hono… #KellyChibale #HonoraryFellow #ChemicalSciences #H3D #GlobalScience

Congratulations to Schmidt Sciences' AI2050 Senior Fellow @Kelly_Chibale on being named an Honorary Fellow of the @RoySocChem. Dr. Chibale was one of seven world-renowned scientists recognized with the RSC's top accolade this year. rsc.org/news/2026-hono…

Design, Synthesis, and Structure–Activity Relationship Studies of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) Inhibitors @ACSBioMed pubs.acs.org/doi/10.1021/ac… #KellyChibale #CancerResearch #Leukaemia #TargetedTherapy #MedicinalChemistry #DrugDiscovery

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and In Vivo in Mice pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #DrugMetabolism #LiverToxicity #MedicinalChemistry #DrugSafety

AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Functional Microglial Activity pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #AlzheimersDisease #Neurodegeneration #AIDrugDiscovery #MedicinalChemistry #Neuroscience #DrugDiscovery

The December issue of #ACSMedChemLett is out today! Amanda Dombrowski summarizes three must read articles In this Issue. go.acs.org/dyI

Zilurgisertib, a potent, selective ALK2 inhibitor, blocks aberrant signalling and prevents heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) models and is now advancing as a first-in-class, disease-modifying therapy @ACSBioMed pubs.acs.org/doi/10.1021/ac…

For the 1-year anniversary of our International Research Network, we're featuring ongoing research from Dr. @Kelly_Chibale & @dr_vinayaksingh Working with Dr. @CCapicciotti, this project is examining nanocluster-bacterial interactions' potential against antimicrobial resistance.

Epigenetic dysregulation drives hepatocellular carcinoma via G9a upregulation. In #ACSMedChemLett, Mu et al. report a novel and selective G9a inhibitor that lowers H3K9me2, restores tumour suppressor expression & outperforms sorafenib in models @ACSBioMed pubs.acs.org/doi/10.1021/ac…

Explore recent developments in CDK-targeting PROTACs-covering linker chemistry, SAR insights, and emerging degradation strategies in cancer therapy. #PROTAC #ACSMedChemLett @ACSPublications @mark_blaskovich @IMBatUQ go.acs.org/dtB

New analogues of the Hsp90/Aha1 disruptor KU-177 reported by Catalfano et al. in #ACSMedChemLett reveal that a cis-amide linker is key for inhibition; a sulfonamide-containing compound showed strong efficacy, solubility and metabolic stability @ACSBioMed pubs.acs.org/doi/10.1021/ac…

just scored this book in the second hand bookstore across the road, ahead of the 6th H3D meeting on drug discovery and global health organized in 2026 by @Kelly_Chibale

Honoured to be named an @ASTMH Distinguished International Fellow and to deliver the Commemorative Lecture at the Closing Plenary in Toronto. Partnership across borders remains vital to advancing global health innovation. 🔗 Read more: astmh.org #KellyChibale

@GlobalFund We must #StopAtNothing to defeat them. We must invest to finish the job. theglobalfund.org/en/investment-…

The @GlobalFund partnership is fighting the deadliest infectious diseases in the most crisis-affected parts of the world. Through this partnership millions of lives have been saved. But there is still more work to do. HIV, TB and malaria have threatened humanity for far too long.

Meet PKM2Pred (go.acs.org/dqF), where AI meets oncology! Instantly discover and predict potent PKM2 modulators, driving faster and smarter anticancer drug discovery. #ACSMedChemLett go.acs.org/dqE

Delivered a seminar at @Tsinghua_Uni where I discussed next-gen antimalarials and shared insights from @ACSMedChemLett. My privilege to engage with global colleagues in science. 🔗acs.org/about.html #KellyChibale #ACS #MalariaResearch #DrugDiscovery #MedicinalChemistry