Kelly Chibale

1/2 #Afropessimism – a term that I often use to emphasize a critical & often ignored issue. It is sad that people don’t trust African scientific #innovation. I always say this & I repeat – as Africans, we must take pride in what is #locallyproduced & support #localproducers.

Researchers have discovered a promising new way to treat pain without opioids. By targeting a specific “pain signal” channel (NaV1.8), Dialer et al. developed compounds that are more selective, longer-lasting and potentially safer: #ACSMedChemLett" target="_blank" rel="nofollow noopener">pubs.acs.org/doi/10.1021/ac… @ACSPublications

Scientists are getting a clearer picture of how diabetes and weight-loss drugs work. By watching receptors on cells in real time, they found that drugs “grab on” in two ways, helping to explain why some treatments work better than others: #ACSMedChemLett" target="_blank" rel="nofollow noopener">pubs.acs.org/doi/10.1021/ac… @ACSPublications

Congratulations Kelly Chibale of @UCT_news, newly inducted NAS international member! #NAS163 #NASmember #chemistry #biology #pharmacology

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway pubs.acs.org/doi/10.1021/ac… @ACSPublications #KellyChibale #AntibioticDiscovery #DrugDiscovery #MedicinalChemistry #AntimicrobialResistance #InfectiousDiseases #GlobalHealth

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid) #DrugDevelopment #MedicinalChemistry #DrugDesign #ProdrugStrategy #InflammationResearch #Immunology #Resatorvid #Pharmacokinetics #DrugRelease #ChemicalBiology

Discovery of a Colon-Targeted Prodrug as an Escherichia coli Biofilm Inhibitor for Treating Inflammatory Bowel Disease pubs.acs.org/doi/10.1021/ac… @ACSPublications #MedicinalChemistry #DrugDiscovery #ProdrugDesign #IBDResearch #InflammatoryBowelDisease #MicrobiomeScience #Biofilms

Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An In Silico and In Vitro Modeling Approach pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #MedicinalChemistry #Hypertension #CardiovascularResearch #ACEInhibitors #DrugDiscovery #ComputationalChemistry

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #MedicinalChemistry #CancerResearch #MitochondrialBiology #OncologyResearch #DrugDiscovery

Maltose-Conjugated Thiosemicarbazones from Substituted Benzaldehydes: Synthesis and Inhibitory Activity against Gram-(+) and Gram-(−) Bacteria pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #AntimicrobialResistance #AntibioticDiscovery #InfectiousDiseases #DrugDiscovery

Now an Honorary Fellow of the #RoyalSocietyofChemistry, its highest accolade. Encouraging to see recognition of science that combines excellence, leadership and societal impact. Read more: rsc.org/news/2026-hono… #KellyChibale #HonoraryFellow #ChemicalSciences #H3D #GlobalScience

Congratulations to Schmidt Sciences' AI2050 Senior Fellow @Kelly_Chibale on being named an Honorary Fellow of the @RoySocChem. Dr. Chibale was one of seven world-renowned scientists recognized with the RSC's top accolade this year. rsc.org/news/2026-hono…

Design, Synthesis, and Structure–Activity Relationship Studies of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) Inhibitors @ACSBioMed pubs.acs.org/doi/10.1021/ac… #KellyChibale #CancerResearch #Leukaemia #TargetedTherapy #MedicinalChemistry #DrugDiscovery

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and In Vivo in Mice pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #DrugMetabolism #LiverToxicity #MedicinalChemistry #DrugSafety

AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Functional Microglial Activity pubs.acs.org/doi/10.1021/ac… @ACSBioMed #KellyChibale #AlzheimersDisease #Neurodegeneration #AIDrugDiscovery #MedicinalChemistry #Neuroscience #DrugDiscovery

The December issue of #ACSMedChemLett is out today! Amanda Dombrowski summarizes three must read articles In this Issue. go.acs.org/dyI

Zilurgisertib, a potent, selective ALK2 inhibitor, blocks aberrant signalling and prevents heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) models and is now advancing as a first-in-class, disease-modifying therapy @ACSBioMed pubs.acs.org/doi/10.1021/ac…

For the 1-year anniversary of our International Research Network, we're featuring ongoing research from Dr. @Kelly_Chibale & @dr_vinayaksingh Working with Dr. @CCapicciotti, this project is examining nanocluster-bacterial interactions' potential against antimicrobial resistance.

Epigenetic dysregulation drives hepatocellular carcinoma via G9a upregulation. In #ACSMedChemLett, Mu et al. report a novel and selective G9a inhibitor that lowers H3K9me2, restores tumour suppressor expression & outperforms sorafenib in models @ACSBioMed pubs.acs.org/doi/10.1021/ac…

Explore recent developments in CDK-targeting PROTACs-covering linker chemistry, SAR insights, and emerging degradation strategies in cancer therapy. #PROTAC #ACSMedChemLett @ACSPublications @mark_blaskovich @IMBatUQ go.acs.org/dtB

New analogues of the Hsp90/Aha1 disruptor KU-177 reported by Catalfano et al. in #ACSMedChemLett reveal that a cis-amide linker is key for inhibition; a sulfonamide-containing compound showed strong efficacy, solubility and metabolic stability @ACSBioMed pubs.acs.org/doi/10.1021/ac…