Kizil Lab

715 posts

Kizil Lab banner
Kizil Lab

Kizil Lab

@KizilLab

Zebrafish, Alzheimer's disease, neural stem cells, regeneration @Columbia @ColumbiaMed | Own views, no endorsements

New York Katılım Ekim 2016
643 Takip Edilen2.1K Takipçiler
Kizil Lab retweetledi
Burke Neurological Institute
Burke Neurological Institute@BurkeNeuroSci·
Last week , Caghan Kizil, Ph.D., from Columbia University Irving Medical Center, presented an engaging seminar on “Fibronectin as a Proximal Mediator of APOE-ε4-induced Blood-Brain Barrier Dysfunction in Alzheimer’s Disease.” See flyer here > buff.ly/s5kCCqc
Burke Neurological Institute tweet media
English
9
24
128
42.4K
Kizil Lab
Kizil Lab@KizilLab·
2024 was an incredible year for #KizilLab! 🎉 ✨ Many publications, 🏆 awards, 💡 innovations & patents! We are proud of our team! Thanks to collaborators, supporters, and @ColumbiaMed for making it all possible. Here's to 2025! #ScienceForAll 🔗 kizillab.org
English
0
1
7
443
Kizil Lab retweetledi
Caghan Kizil
Caghan Kizil@CaKizil·
🔑Highlights: - Pacemaker-like neurons in the IcNS, generating rhythmic activity autonomously 🧠💓 - A complex diversity of neurotransmitter systems finely tuning heart rhythms 🔬 - Ex-vivo study of intact neural heart networks 🧪 Why it matters: This research challenges the idea that the heart is just a simple relay, positioning the IcNS as a key player in rhythm generation. A leap toward new therapeutic strategies for arrhythmia and heart failure.
Caghan Kizil tweet media
English
1
4
14
2.9K
Kizil Lab retweetledi
Caghan Kizil
Caghan Kizil@CaKizil·
This collaborative effort from teams at @karolinskainst and @Columbia @ColumbiaMed, led by @AmpatzisLab and @KizilLab, showcases the power of teamwork. Congratulations to all authors, including the first authors Andrea Pedroni and @gaattagca! 🙌 This work wouldn’t have been possible without the generous support of our funding agencies; thank you! 🙏
Caghan Kizil tweet media
English
1
2
14
2.6K
Kizil Lab retweetledi
Caghan Kizil
Caghan Kizil@CaKizil·
🚨 Our new study "Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system" out in @NatureComms! 🌟 We identify the "little brain" of the heart: the intricate intracardiac nervous system (IcNS) of zebrafish! 🐟 Learn more here about how this changes what we know about heart functionality. nature.com/articles/s4146… 🧵 #Cardiology #Zebrafish #Neuroscience #HeartResearch #LittleBrain
English
4
6
50
6.8K
Kizil Lab
Kizil Lab@KizilLab·
We are happy to share that our ABCA7 paper published in @CellGenomics 🎉 Thanks to all our collaborators.
Caghan Kizil@CaKizil

We're excited to share our new study on the role of the ABCA7 gene in brain resilience against #Alzheimer’s. Published in @CellGenomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating #neuropeptide Y (NPY), a key molecule for brain communication and repair. Loss of ABCA7 reduces NPY, weakening the brain's defenses against AD. By combining #zebrafish models, human datasets, and #patient-derived iPSCs, we discovered that ABCA7 variants impact synaptic integrity and brain function. Our study also highlights how Alzheimer mechanisms mechanisms vary across different ethnicities. Understanding ABCA7's role in diverse populations can help develop more targeted and effective treatments. By targeting #ABCA7 and boosting NPY signaling, future therapies could offer better protection against AD, giving us hope for new treatment strategies. #Neurodegeneration #DiversityInResearch #HealthEquity #BrainHealth Study Shows How Common Genetic Variants in Black Americans Increase Alzheimer’s Risk cuimc.columbia.edu/news/study-sho…

English
1
1
7
492
Kizil Lab retweetledi
Caghan Kizil
Caghan Kizil@CaKizil·
ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling: Cell Genomics cell.com/cell-genomics/…
English
0
2
10
3.6K
Kizil Lab
Kizil Lab@KizilLab·
It was sad to bid farewell to our Nastasia today but we're excited for her that she's off to start a PhD @Columbia. Nastasia has contributed enormously to all our projects and we were so lucky to have her! We all so proud to see her growth, and can’t wait to call her Dr. Nelson!
Kizil Lab tweet media
English
0
1
7
417
Kizil Lab retweetledi
GiusTo Lab
GiusTo Lab@GiusToLab·
We now have a zebrafish model 🐟 to better dissect the genetics underpinning Fetal Alcohol Spectrum Disorders #FASD - thanks to @CaKizil @gaattagca @NIAAAnews preprint here 👇🏼 biorxiv.org/content/10.110…
GiusTo Lab@GiusToLab

A new project from our lab! Fascinating #admixture study on this underrepresented South African population and the risk profile for Fetal alcohol spectrum disorders #FASD. 1% to 5% of U.S. first graders have FASD! @NIAAAnews medrxiv.org/content/10.110…

English
1
4
5
756
Kizil Lab
Kizil Lab@KizilLab·
Check out our latest review: “Multi-target drugs for Alzheimer’s disease” cell.com/trends/pharmac…
Caghan Kizil@CaKizil

Our review is out in @TrendsinPharma. Multi-target drugs for Alzheimer's disease "Traditional therapies aimed at single targets have fallen short owing to the complex, multifactorial nature of #Alzheimer's disease that necessitates simultaneous targeting of various #disease mechanisms for #clinical success. Therefore, targeting multiple pathologies at the same time could provide a synergistic #therapeutic effect." @KizilLab cell.com/trends/pharmac…

English
0
0
4
345
Kizil Lab retweetledi
Caghan Kizil
Caghan Kizil@CaKizil·
Bizim için çok heyecan verici bir haberi paylaşmak istiyorum. Yeni çalışmamızda, insanlarda #Alzheimer riskini %71 azaltan bir #genetik değişimi ve bu değişimin etki mekanizmasını açığa çıkardık. Bu bulgu, milyonlarca insanı hastalıktan koruyabilir ve Alzheimer'ın önlenmesi ve tedavisinde yeni yollar sunabilir. @ColumbiaMed yapılan ve @Stanford , @Yale, @MayoClinic gibi enstitülerden araştırmacıların da dahil olduğu bu çalışma, hastalığı önleyebilecek genetik bir faktörün varlığını ortaya koyuyor. #Alzheimer #Bilim #Sağlık cuimc.columbia.edu/news/newly-fou…
Türkçe
239
1.4K
9.1K
755.7K

Keşfet

@ColumbiaMed @karolinskainst @Columbia @AmpatzisLab @gaattagca @NatureComms @CellGenomics @CaKizil