Korkhov Lab

The @KorkhovLab has an opening for a student or a scientist displaced from Ukraine. If you are interested or know someone who might be interested - please DM.

How do cells integrate multiple signals into precise responses? Our study uncovers neuronal calcium sensor proteins as new regulators of adenylyl cyclase 8, linking GPCR/cAMP and Ca²⁺ signaling. @KorkhovLab @psich_en @ETH_DBIOL biorxiv.org/content/10.648…

A new twist in the cAMP-Ca2+ signaling crosstalk: Neuronal calcium sensors emerge as novel adenylyl cyclase 8 regulators! biorxiv.org/content/10.648…

Membrane Adenylyl Cyclases are tough cookies when it comes to in vitro structure-function studies. Ilayda Kantarci and Haoriwa used a chimeric construct strategy to crack isoform‑specific AC regulation 👇 biorxiv.org/content/10.648…

Our study on the lipid dependence of Cx32 gap junction channel conformations is now out in @NatureComms. Amazing work by @PLavriha, @FluriCarina, and Jorge Hernández González! nature.com/articles/s4146…

Our manuscript on the distinct mechanisms by which drug-like small molecules target the malaria parasite transporter PfNCR1 is now on bioRxiv 👇 biorxiv.org/content/10.110…

Our manuscript exploring the radiation dose effects on protein structure is now online, underscoring the great promise of correlative workflows combining X‑ray tomography with cryo‑EM at high resolution 👇 biorxiv.org/content/10.110…

In collaboration with the Posthaus Lab, we identify ANTXR2—also the anthrax toxin receptor—as the receptor for Clostridium perfringens NetF pore forming toxin. Cryo-EM shows extensive contact between the pore and the receptor #Microbiology #CryoEM doi.org/10.1101/2025.0…

Our investigation of lipid dependence of Cx32 gap junction channel conformations is now online on @biorxivpreprint. Great work by @PLavriha, @FluriCarina and Jorge Hernández González! biorxiv.org/content/10.110…

#Authorinterview: Basavraj Khanppnavar a structural biologist and biochemist talks about his work on "Molecular Snapshots Unravel Botox’s Secrets of Nerve Cell Entry". #botox #cryoEM #neuron @BasurajSK @KorkhovLab @ETH_en biopatrika.com/academia/resea… via @biopatrika

Happy to share our latest publication on @NatureSMB Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. nature.com/articles/s4159… nature.com/articles/s4159… thanks @SjorsScheres and @MichelGoed support 🥳🥳🥳

Want to know “How does #Botox enter neuronal cells at the right time & place to exert its #therapeutic effect?” Check out our latest paper @NatureComms @psich_en @eth_en @ETH_DBIOL @KorkhovLab.nature.com/articles/s4146…

Our joint study led by @BasurajSK and Oneda Leka, on the interactions between botulinum neurotoxin BoNT/A1 and its receptor SV2B, is now out in @NatureComms. This was a great collaboration with the group of Richard Kammerer (@psich_en)! rdcu.be/d9rOL

Excited to share that I've been elected as member of the "Junge Kolleg" of the Nordrhein-Westfalian Academy of Sciences and Arts. I'm honored to have this opportunity to serve the community! Here's the link to the announcement, unfortunately only in German awk.nrw/news/nachwuchs…

@vercellino_ire @SachseGroup Congratulations Irene!

Honored to have received the #ForWomenInScience #FWIS2024 award. Thanks to #Loreal #LorealGroup #UNESCO, the selection committee, the organizers of the amazing ceremony and to my family that supports me doing science! #StopTheDropout #EqualOpportunity #WomenEmpowerment

Authors from @Gschertler lab, @psich_en report structures of an activated bistable opsin, a bidirectional photoswitch. nature.com/articles/s4146…

Captain Aureispira - a bacterial pirate ship🦜🏴‍☠️🪝- boarded @ScienceMagazine. Check out the manuscript here: science.org/doi/10.1126/sc… and have a look on our extended thread below ⬇️We provide new insights on bacterial predation from molecules ⚛️to ocean samples 🌊

CryoEM structure of the human Connexin-43 gap junction channel (PDB code: 8QKO) #scivis #molecularart #sciart @dzine_ai @proteinimaging behance.net/gallery/209149…

Our work on the regulation of the gamma-tubulin ring complex is now online @Dev_Cell! Huge congratulations to all co-authors involved! Open access link to the paper: cell.com/developmental-…

The gamma-tubulin ring complex controls microtubule nucleation in cells. The @MikeVVieczorek lab demonstrates that CDK5RAP2 regulates the structure of the gamma-tubulin ring complex to dramatically promote its microtubule-nucleating activity. More: biol.ethz.ch/en/news-and-ev…