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Kudla lab
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Kudla lab
@kudlalab
Group at @mrc_hgu @EdinUni_IGC @EdinburghUni, using synthetic biology and machine learning to understand genotype-phenotype relationships in RNA and proteins.
Edinburgh, Scotland Katılım Aralık 2020
127 Takip Edilen318 Takipçiler
Kudla lab retweetledi
Excited to see this work led by @kudlalab is now out, showing that PAX6 DNA binding measured in a yeast 1-hybrid deep mutational scan outperforms existing computational approaches for variant classification embopress.org/doi/full/10.10…
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Kudla lab retweetledi
Excited to share our Perspective on the new AlphaMissense variant effect predictor tool from @GoogleDeepMind @ScienceMagazine science.org/doi/full/10.11…
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We have an open postdoctoral position on deep mutational scanning of transcription factor genes @kudlalab @mrc_hgu @varianteffects. Apply by 4th October! jobs.ac.uk/job/DCK493/res…
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Kudla lab retweetledi
Our partners @IIMCB_Poland are recruiting junior group leaders - excellent support available to start your independent career in this internationally recognised and vibrant scientific environment
IIMCB, Warsaw, Poland@IIMCB_Poland
📣 @IIMCB_Poland is recruiting‼ ✔ Who? Junior Group Leaders✌ 👉 All the details: bit.ly/3Y0fXYI #IIMCB #TeamingForExcellence #HorizonEurope #research #development #Science
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Thanks for these kind words @AbbeAtSea. Looking forward to meeting you and many other codon usage enthusiasts at our EMBO Workshop in Edinburgh next week!
The Lab LaBella@Lab_LaBella
Only 1 more week until the #EMBO_CU22 conference co-organized by Grzegorz Kudla @kudlalab at @EdinUni_IGC. Professor Kudla has made significant findings in the codon world by combining synthetic biology, next-gen sequencing, and computational modelling #3rdBaseThurs @rokaslab
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Kudla lab retweetledi
Nothing in genomics or transcriptomics makes sense except in the light of G/C content
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Kudla lab retweetledi
our paper is now out @Nature ! nature.com/articles/s4158…
a 🧵on the excitement and value of Basic Science, DNA replication and repair, teamwork and collaboration, and the fundamental incompatibility of LEGO and DUPLO 1/n
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Kudla lab retweetledi
This is the best lab trick I've seen in ages.
Anca Farcas@AncaMFarcas
When your husband is a nerd who did his PhD in Scotland and uses IrnBru to stain his western blot membranes…it works amazingly if you ever run out of Ponceau!
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Join us in Edinburgh for the 1st EMBO workshop on codon usage function, mechanism and evolution. Three weeks left to register!
MRC_HGU@mrc_hgu
Excited to be hosting an outstanding and diverse array of researchers with insight on the codon usage bias phenomenon. 1st EMBO workshop on codon usage function, mechanism and evolution at the Royal College of Physicians of Edinburgh, April 8-11, 2022 meetings.embo.org/event/21-codon
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Antibiotic resistance in the pathogenic bacterium Klebsiella pneumoniae mediated by a single synonymous mutation in outer membrane porin gene @TheFrankelLab @RouskinLab.
biorxiv.org/content/10.110…
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Kudla lab retweetledi
We’ve created calculator that aggregates deep mutational scanning data to estimate how mutations to #SARSCoV2 RBD affect recognition by human polyclonal antibodies. The calculator emphasizes extensive antigenic change in #Omicron variant. jbloomlab.github.io/RBD_escape_cal… (1/n)
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Kudla lab retweetledi
Add your name! Registration now open for the EMBO Workshop on RNA: Structure meets function, 27 June – 1 July 2022 in Åkersberga, Sweden meetings.embo.org/event/20-rna-s… #EMBOrna
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Proud of @CMordstein for spearheading this!
Christine Mordstein@CMordstein
👉 Transcription, mRNA export and immune evasion shape the codon usage of viruses Happy to see another joint-effort from @KudlaLab & @Prof_LDHurst lab out now @GenomeBiolEvol bit.ly/3hv4hef We tried to address some fundamental questions re virus codon usage: (short🧵)
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Kudla lab retweetledi
New preprint!📜📢 "Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity". A great collaboration between Sveta from my lab, @omerz213 @ericmiskalab @ericmiska and @kudlalab .
What did we find? A 🧵 biorxiv.org/content/10.110… 1/11
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Kudla lab retweetledi
The #AI revolution in protein structure prediction continues, as researchers have unveiled a combination of programs that can determine which proteins are likely to interact with one another and what the resulting complexes look like. fcld.ly/ew2zce2
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@oromncrna If your preprint was published under a copyright license, you should inform the publisher of the other paper that they are infringing the copyright, and ask them to withdraw the paper. Good luck with this ;)
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Kudla lab retweetledi
Application is now for our 4 year #PhD programme including Human Genetics, Genomics and Disease and projects for International Quantitative Scientists. Closing date 7 January 2022, details here:
ed.ac.uk/mrc-human-gene…
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Accessibility of translation initiation sites is the strongest predictor of heterologous protein expression in E. coli
journals.plos.org/ploscompbiol/a…
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