LASID

🚨 Join our upcoming webinar! Inborn Errors of Immunity in Latin America: from suspicion to treatment 📅 April 21, 2026 🕗 8:00 PM (Mexico City time) 🎓 Recertification credits (CMCP & CONICA) 🔗 Register now: us02web.zoom.us/webinar/regist… #IEI #Immunology #PrimaryImmunodeficiency

We’re thrilled to kick off the 2026–2027 LASID journey, guided by our Secretary, Dr. Gisela Seminario from Argentina 🇦🇷 Together, we continue building a stronger community driven by science, collaboration, and a shared passion for immunology 🧬💫

Today, on World Health Day, we join the global community under the theme “Together for health. Stand with science.” For the IEIs means promoting early diagnosis, improving access to care, and building equitable, patient-centered health systems across Latin America.

Insightful study !! Response to recombinant human granulocyte colony-stimulating factor in reticular dysgenesis rupress.org/jhi/article/2/…

Perspective: Paul E. Gray, @sethmasters, and @edwin_kirk argue that the lack of large association studies between Yao-associated variants and clinical phenotypes mean that the diagnosis should not be used in the literature or in the clinic. hubs.la/Q049GYPC0 #Autoimmunity

Using single-cell RNA-seq, Manabu Wakamatsu, Megumu Saito @CiRA_KU_E, Hideki Muramatsu @NagoyaUniv & colleagues show that rhG-CSF suppresses IFNγ signaling and promotes B-cell differentiation in reticular dysgenesis, with potential benefits before #HSCT. hubs.la/Q049Jh6g0

We’re kicking off 2026 with a warm welcome to our LASID community, led by our Vice President, Dr. Cecilia Poli from Chile. Here’s to a year filled with shared knowledge, collaboration, and a deep passion for immunology. 🧬✨

In this Perspective, Casanova @casanova_lab discusses the 30-year history and future implications of emerging science showing that monogenetic lesions, and #autoimmune disorders targeting the same components of host defense, can underlie the same infection hubs.la/Q048F5Zz0

@jhumimmunity @casanova_lab Amazing 🤩

Journal of Human Immunity (JHI) @jhumimmunity is here! Read the inaugural editorial by @casanova_lab outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. hubs.la/Q038p-Gl0 #OpenAccess

@jhumimmunity 👏🏼

Publishing in JHI enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: hubs.la/Q048m9QY0

ATTENTION 🚨- Primary Immunodeficiency Week is approaching. If you are a LASID member, we invite you to send us a video telling us where you are from and sharing something interesting about how these diseases are managed in your country. #lasid #immunity #inbornerrorsofimmunity

Rare variants in CYBB (encoding gp91phox) are responsible for chronic granulomatous disease. Roelens, @BustamanteJaci1 et al. report a patient affected by multiple cerebral abscesses caused by #Acanthamoeba sp. and complete gp91phox deficiency. hubs.la/Q046bZrp0 #CGD

Tomomasa, Nishimura, Kanegane et al @sciencetokyo_en investigated #tumorigenesis mechanisms through transcriptomic profiling & somatic variant analysis in tumor samples from six patients with X-linked lymphoproliferative syndrome type 1 (XLP1). hubs.la/Q046yWZv0 @APSID_PID

Gervais, Trespidi, Ferrari, Rovida, Cobat, Zhang, Casanova, Borghesi et al. show that, in 13 European, Middle-Eastern, and American cohorts, pre-existing autoantibodies neutralizing type I IFNs are causal for WNV encephalitis in about 40% of patients. hubs.la/Q046JZ5J0

Thalhammer et al. report the first successful hematopoietic stem cell transplantation for HEM1 Deficiency. A girl (5y) underwent #HSCT with a MSD after RTX, Alemtuzumab, TTF conditioning for recurrent infections and EBV-induced HLH and is fine 3y post HSCT hubs.la/Q0476-R50

Perspective: Etienne Pays proposes that the lipid-interacting proteins of the APOL families specifically control cellular membrane dynamics involved in processes linked to immunity, like antigen presentation, inflammation, mitophagy, & apoptosis. hubs.la/Q047HvN30

Perspective: Garcia-Solis, Pérez de Diego, and Sánchez-Ramón @SaludMadrid examine genetic testing advances in #InbornErrorsOfImmunity, highlighting challenges in variant interpretation and the need for standardized approaches. hubs.la/Q047LwW90 @ESIDsociety

Fréret, Escudier et al. describe a child with #IPEX due to a #FOXP3 mutation, presenting with carotid perivasculitis consistent with TIPIC syndrome on multimodal imaging, who achieved clinical and radiologic remission after corticosteroids. hubs.la/Q048kVC00

if you are a LASID member, we are looking for you! 🕵️