LifeScienceAlliance

👉 SATB1 preserves CD4⁺ T cell fidelity and establishes Treg function in anti-tumor immunity @KyotoU_News hubs.la/Q04pBHxQ0

Check out this interesting article recently published in LSA: The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation @LaUASLP hubs.la/Q04pC8D90

Read Dr. Rossy and colleagues’ LSA article, “A “scan and stop” assay identifies CD40 and CD70 as selective regulators of T-cell arrest on APCs.” life-science-alliance.org/content/9/8/e2…

“The reviewers provided constructive, relevant feedback that strengthened our manuscript, and the editorial team was supportive.”— Jérémie Rossy, University of Konstanz. Learn more about publishing in LSA: hubs.la/Q04l_zkd0

Targeted smn-1 silencing in C. elegans caused distinct defects and differences in sensitivity between neurons of the same class. We present a robust framework to dissect the mechanisms underlying selective neuronal vulnerability of SMA. hubs.la/Q04pBGCT0

EPAS1 reveals convergent hypoxia adaptation in subterranean rodents: Chinese zokors carry a stabilizing T480S variant, while Israeli blind mole rats show regulatory changes linking hypoxia and interferon pathways. @ZJU_China life-science-alliance.org/content/9/9/e2…

Septin7 is essential for hematopoietic stem cell development but dispensable for cytokinesis in myeloid and lymphoid progenitors. Moreover, it is not required for lymphoid development under either steady-state conditions or oncogenic stress. hubs.la/Q04pBJXV0

Full paper here: life-science-alliance.org/content/8/10/e…

Epigenetic liquid biopsies reveal endothelial turnover and erythropoiesis in asymptomatic COVID-19 in our Genetics, Genomics, and Epigenomics collection hubs.la/Q04ln0DL0

Have you already seen our Cancer Biology Collection hubs.la/Q04lxkcd0 and read this paper? hubs.la/Q04lxgs90

Extended therapeutic inhibition of CDK4/6 pushes cancer cells into a senescent-like state and can trigger NF-κB activation to induce an inflammatory signature. @JoannaYeung7 @just_mich_rend @vivrisca @RockefellerUniv hubs.la/Q04pD4990

Upstream regulators of membrane repair in response to pore-forming toxins are poorly understood. Data here support Vav2 acting in annexin, MEK, and dysferlin-mediated repair @TexasTech @_Kaygbeng hubs.la/Q04p7Mzm0

SATB1 regulates FoxP3 expression, preserving lineage fidelity in conventional CD4+ T cells maintaining FoxP3 target gene repression in Tregs. Deleting SATB1 disrupts Treg function, unleashing potent anti-tumor immunity. @KyotoU_News life-science-alliance.org/content/9/10/e…

Read this paper RB dependent transcriptional regulation at mitotic centromeres preserves genome stability hubs.la/Q04lxDX40 in our Cancer Biology Collection 2026: hubs.la/Q04lxqDL0

In a male rat model of metabolic syndrome, renal denervation before the high-fat diet has only a transient effect, suggesting that hypercaloric diet-induced endocrine changes trigger hypertension independently of renal sympathetic activity. @LaUASLP life-science-alliance.org/content/9/10/e…

smn-1 silencing in C. elegans caused distinct defects in neuronal process morphology with pronounced neuron-specific differences in sensitivity between neurons of the same class. life-science-alliance.org/content/9/9/e2…

Septin7 is widely considered essential for cell division. Surprisingly, deleting Septin7 in lymphoid and myeloid cells does not impair blood cell development. We show that Septin7 is required during early hematopoiesis but not at later stages. life-science-alliance.org/content/9/10/e…

Take a look at this Methods paper recently published in LSA: DiffMethylTools:a toolbox of the detection, annotation and visualization of differential methylation @unlv hubs.la/Q04nNxch0

1 Read the full paper 👉️ life-science-alliance.org/content/8/9/e2…

This work in our Genetics, Genomics, and Epigenomics collection illustrates the importance of accounting for EPIC version in DNA methylation-based tools, specifically in research scenarios when samples profiled across different versions are harmonized. hubs.la/Q04lnKs60