LifeScienceAlliance

Have you already read a paper recently published in LSA? RhoGEF Ect2 Supports RhoA Activity at Cell-Cell Junctions through Desmoplakin @NUFeinbergMed 🔗 hubs.la/Q046Gs_K0

The epigenetic writer DOT1L guides the development of dendritic cells through its catalytic activity, differentially affecting canonical dendritic cell subsets. @vanLeeuwenLab @NKI_nl life-science-alliance.org/content/9/6/e2…

This paper finds that modulating RNA tailing and decay enzymes can regulate proteo-toxicity in Alzheimer's and Parkinson disease models. @univmiami life-science-alliance.org/content/9/6/e2…

LSA’s Academic Editors are active, internationally recognized scientists whose leadership ensures rigorous & fair peer review. Scientific excellence begins with scientific leadership. Read the announcement, where scientific excellence sets the standard. hubs.la/Q046vPxF0

This study of protein interactions of HTT using multiple approaches supports its role in facilitating the emerging integration and interplay between DNA damage/remodeling and RNA processing pathways. @JohnsHopkins life-science-alliance.org/content/9/6/e2…

TBXA2R signaling activates ERMs through Gαq/11-Gα12/13, Rho GTPases and SLK/LOK, boosting TNBC cell migration, invasion and metastatic colonization. @ReviewCommons life-science-alliance.org/content/9/6/e2…

This study shows that natural compound KQS-1 alleviates airway inflammation and hyperresponsiveness by enhancing Treg cell function via Dectin-1 signaling, offering a novel potential therapeutic strategy. @ShenzhenUni life-science-alliance.org/content/9/6/e2…

The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface hubs.la/Q046k_dz0

Authors uncover a feedback loop between PARN and miR-29a/miR-1207: PARN (via CPSF6) regulates pri-miRNA levels, while miR-29a-3p and miR-1207-5p target PARN mRNA. This regulatory circuit also impacts cell migration. life-science-alliance.org/content/9/5/e2…

Perfect example of modeling/theory combined with observation/experimentation. Neither is sufficient alone but together they are very powerful.

Check out this recently published paper in LSA: F-Actin organization excludes E-cadherin from the division furrow to ensure cytokinesis fidelity @anups_11 ➡️ hubs.la/Q045Rw3C0

The authors describe a mechanism by which the desmosome component, desmoplakin, can recruit and control the activity of the contractile signaling regulator RhoA at cardiomyocyte and keratinocyte intercellular junctions. @NUFeinbergMed life-science-alliance.org/content/9/6/e2…

Mitochondria drive energy conversion and cell fate. A new approach combines AFM imaging with nanoscale phenotyping to analyze single mitochondria label-free. 🔬 @ReviewCommons hubs.la/Q045RqJk0

We’re pleased to welcome Guangshuo Ou as a new Academic Editor at LSA. A respected cell and developmental biologist, he brings deep expertise and a global perspective to the journal. Learn more in LSA, where scientific excellence sets the standard. hubs.la/Q0461MCs0

Based on a combination of in silico and cell biological analyses, this study suggests that the APOL1 variant p.N264K (M1) may prevent G2-mediated kidney toxicity by physically blocking ion flux. life-science-alliance.org/content/9/5/e2…

Metformin improves RAN protein pathology 🧬, alternative splicing 🔄, and behavioral phenotypes 🐭✨ in SCA8 mice @UF👇 hubs.la/Q045mv-Y0

#NewPublication The lung doesn’t just defend itself—it retunes its defenses. New study from Dr. Arjun Guha (@ArjunGuha1) lab at BRIC-inStem finds Notch signaling drives active remodeling of airway cilia and highlights the critical role of small airways in lung disease biology. Featured on the March 2026 cover of @LSAjournal. Read more in our press release here: instem.res.in/media-center/ @DBTIndia @BricDbt @ChanZuckerberg @CSIR_IND #LungBiology #RespiratoryResearch #SmallAirways #ScienceNews #NewResearch #ResearchHighlights #PressRelease

Tissue-specific I-Smad mechanisms revealed by structure–function analysis in Drosophila @SCSU @mikolajsulkows1 hubs.la/Q0456By20

E-cadherin localization in the cytokinetic furrow links to reduced division fidelity. Formin-actin at the division zone restricts its lateral mobility. @anups_11 life-science-alliance.org/content/9/5/e2…

Label-free approaches that report both functional & physical state of single-mitochondria are nonexistent. Combination atomic force microscopy (AFM) imaging with single-mitochondrion phenotyping by quantifying parameters at the nanoscale.@ReviewCommons life-science-alliance.org/content/9/5/e2…