CASL_lab

We discovered two P450 enzymes AscB/MmsB, catalyze a Tyr-C3-Trp-N1 cross-link and hydroxylation at Trp-C5 in the YxWxH motif. Interestingly, only AscB can catalyze additional Trp-C4-His-Nτ, generating a fused cyclophane RiPPs | Organic Letters doi.org/10.1021/acs.or…

Today, Carlos is finishing his research exchange at LIOS. We had a great time collaborating on new TPP riboswitch ligands 🔬🤝within project #ESfondi #LZP #PostdocLatvia #PostdocLatvija. Nr.1.1.1.9/LZP/1/24/010 "Jauni TPP riboslēdža ligandi kā potenciālas antibiotikas" ✨

A great day in the lab for #ShadowDays2026! 🧪✨#ESfondi, #LZP #PostDoc #Pecdoktorantura #PostdocLatvia #PostdocLatvija #FLPP

Excited to present our latest results on Antibody-drug conjugate warheads at ADC London 2026 #RRF project No.5.2.1.1.i.0/2/24/I/CFLA/001

Six months of work in one small envelope — the first compound library prepared within #ESfondi, #LZP #PostDoc #Pecdoktorantura #PostdocLatvia #PostdocLatvija. Nr.1.1.1.9/LZP/1/24/010 "Jauni TPP riboslēdža ligandi kā potenciālas antibiotikas"

Ending the year on a high note with a joint paper with @chinsoonphan group: P450 Cyptide Synthase KwwB Catalyzes Trp-C5–Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides | Organic Letters pubs.acs.org/doi/10.1021/ac…

Congratulations to Viktors on successfully defending his PhD thesis! Great job, and thanks @KrJaudzems for inviting us on this incredible journey! 🚀

Excited to be a part of Highlighting Organic Chemistry in Latvia youtu.be/3RCv1zkWHCY?si… via @YouTube

Exciting news — Niklāvs’ total synthesis of an indole alkaloid just got featured on the Organic Chemistry Portal!💪 organic-chemistry.org/Highlights/202…

Niklāvs and Rebeka are presenting our latest results at #ACSFall2025. An amazing meeting and lots of inspiring discussions🧑‍🔬#FLPP

Group Outing '25🤠 Just for clarification - it is Airsoft 😆

Acetals from Esters in just one step: check out our latest paper in @JOC_OL #FLPP💪 pubs.acs.org/doi/10.1021/ac…

Check out our latest paper on selective ester reduction @JOC_OL conducted within our #FLPP project! 😎 doi.org/10.1021/acs.jo…

Happy to host a highly motivated pupil, Irina, within our #FLPP project on spider silk! 💪

Happy to share our second independent work. We studied P450 biarylitide synthase, ShyB catalyze His-to-Tyr crosslink | Org Lett @JOC_OL doi.org/10.1021/acs.or…

Rebeka explains the principles of chromatography -one of the main workhorses in synthetic chemistry - to young chemists😎 #FLPP

Niklāvs paper is online, good job! 🥂 pubs.rsc.org/en/content/art…

Fruitful collaboration between our lab and @chinsoonphan group at @osi_lv . Hope it is just the beginning! 😉

The Latvian Institute of Organic Synthesis invites applications for a Postdoctoral Researcher position in medicinal chemistry. Application Deadline: 13 February. Find out more: osi.lv/en/vacancies/

Nice memories from our Christmas party 2023 🎅