marek mutwil 🇺🇦

1/ How conserved are plant stress responses across 1 billion years of evolution? We built a cross-kingdom stress atlas spanning 36 species, from green algae to angiosperms, across 9 stresses. 13.6M DEG calls from 3,200+ manually curated experiments. 🧵biorxiv.org/content/10.648…

🌍 36 species, 🌡️ 9 stresses, 📈 6 figures, 💻 ~150 scripts, 📝 ~80 wiki articles. Hopefully useful for anyone extending the work. 🔗 Vault: publish.obsidian.md/mutwillab/Home… 🐙 Scripts: github.com/mutwil/Kingdom… 📦 Models + data: Figshare

Why on top of a GitHub repo? Scripts alone don't tell you why something was chosen, what was tried and dropped, or how panels connect across figures.

We made the computational vault for the Kingdom Stress Atlas (biorxiv.org/content/10.648…) public. Not just the scripts — the why behind them too. 🧵👇 publish.obsidian.md/mutwillab/Home…

@eugenekoh_ROS @iniemohk YOU DIED

@iniemohk Yeah, it’s called elden ring

Someone should make a video game that is actively harmful, not like its propaganda for dangerous opinions but just simply playing it somehow measurably deteriorates your physical/mental/emotional health like just booting it up and playing for an hour guarantees you ruin your day

@eugenekoh_ROS Hopefully more ups than downs!

Working with Marek has been an amazing journey. Jump on this amazing opportunity!!

🌿 mutwillab.com just got a refresh — organised around our three research pillars (gene function prediction · stress resilience · evolution of regulatory circuits), with all our open tools, papers, and team in one place. And we're hiring 5 PhDs + 1 postdoc 👇

And huge congratulations to @pengkenlim , who just gratudated as Dr. 40 minutes ago!!

Code: github.com/pengkenlim/TEA… networks for 10 angiosperms: plantgcn.connectome.tools Paper: doi.org/10.1038/s41467…

New in Nature Communications: TEA-GCN — a method for building gene co-expression networks from messy public RNA-seq data, without manual sample curation or batch correction. 🔗 github.com/pengkenlim/TEA… nature.com/articles/s4146… 🧵👇

@lpachter @wtgowers What do you think the future will bring?

Interesting blog post by @wtgowers on (training to do) mathematics and AI. His conclusions hold equally well for computational biology. gowers.wordpress.com/2026/05/08/a-r…

Preprint alert: Arabidopsis has ~18,750 genes with experimental GO annotations. Norway spruce has 30. Our ORBIT aligns coexpression networks across 153 plant species into one shared space, enabling functional knowledge transfer to non-model lineages. biorxiv.org/content/10.648… 🧬🌱

Excited to announce the launch of the AI for Plant Sciences (AI4PS) consortium🎉Uniting global efforts to advance AI tools and applications in plant science for the benefit of humanity. Website: ai4ps.net Stay tuned for updates, resources, and opportunities!

@szintri @novonordiskfond @KU_PLEN Thanks!

@LabMutwil @novonordiskfond @KU_PLEN Congratulations and good luck!

Thrilled to receive the @novonordiskfond ASCENDING Investigator grant! Over the next 5 years, my group at @KU_PLEN will use AI and knowledge graphs to predict gene function in plants and engineer climate-resilient crops. Grateful for the support! researchleaderprogramme.com/recipients/mar…