Spiegelman Lab

When we discovered irisin in 2012 (Bostrom et al), we described its actions in terms of the browning of the white fat and anti-diabetic effects. Here, in collaboration with the Mathis lab, we re-examine this in mechanistic detail. nature.com/articles/s4225…

@LabSaltiel Definitely high standards on the AI-enhanced picture of you.

UC San Diego Professor Elected to American Academy of Arts today.ucsd.edu/story/ucsan-di… As several of my friends have commented, standards seem to have slipped.

It is interesting to note, that much of the effects of irisin can be ascribed to the subsequent production of IL-33 by stromal cells within the adipose tissues. We never imagined such a mechanism in 2012! Big congrats to Mu and Gang for these determined efforts.

Lab alums Hage Sprenger and Louisa Grauvogel cut loose at Karneval in Köln!!

@BarteltLab Oh, I love me some Boney M!!

@LabSpiegelman Would love to have a Ra-Ra-Rasputin look but I have gone completely white over the last few rounds of revision

Typical lab group picture

@LabSaltiel That's a beautiful piece Al. The invention of affinity chromatography was and remains a fundamental tool in biochemistry and molecular biology! RIP to a very important scientist.

The longer version of my tribute to Pedro Cuatrecasas.

@LabSaltiel Who invented that picture of you looking so young?

Three UC San Diego Professors Inducted Into the National Academy of Inventors for 2025 today.ucsd.edu/story/three-uc…

Last day of fishing is such a bittersweet day!

Beware of scary scientists on Halloween!

Here is @Rongtian2's News & Views article: nature.com/articles/s4416… @LabSpiegelman @rosenzweig_a

Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!) nature.com/articles/s4416…

@ManagerTactical Dude, I enjoy your channel but your hatred of MLS is boring 🥱 were you outraged when players were called up from Belgian or non-big 3 Dutch teams?

The USMNT 🇺🇸 CB depth is bad but not bad to a point where you call up Tristan Blackmon. Pochettino continues his streak of bizarre selections.

Davo was a fantastic cook. This is after our last fishing adventure is June 2025

The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 chapelgazette.cfd/david-mangelsd…

@CharlieDavies9 @clint_dempsey I'm also an adopted CC-er. Born in NY, faculty in Longwood area at a place you know very well. Boat in Dennis, house in Brewster. Where you at? DM here if you wanna

@LabSpiegelman Thank you, Bruce! I’m actually a converted Cape Codder. I grew up a NH lakes kid but my wife made me see the light. 😎 Once you’re exposed, it’s a no‑brainer! Would love to take you up on that fishing invite sometime. 🎣 You down @clint_dempsey?👀

A new chapter begins ✍🏾⚽️ I’m beyond excited to officially join The Athletic as a featured writer through the 2026 FIFA World Cup! Thank you to everyone who has supported me along the way. 🙏🏾 tinyurl.com/ms4899bs

It's not true that Jared Rutter can only do metabolite signaling! @CapeCod Bay

Matt Gilbert and Krys Seremak cartooning the boss's favorite saying at lab meetings 🤣

@amabulfotouh We all look forward to your arrival!

@LabSpiegelman A great picture of a wonderful team!

Another great Spiegelman Lab Retreat goes in the record books. Everybody gives a talk, but it can't be what you work on! Stretch the mind.