Frontiers in Bioscience-Landmark

💡All articles in Frontiers in Bioscience-Landmark (ISSN: 2768-6698)--Volume 31, Issue 2--, are now freely available to access, read and download: imrpress.com/journal/FBL/31… The editorial team has selected some featured articles for you—inviting all readers to explore and share! Featured Article: 1️⃣ #Ferroptosis Induction is Insufficient to Ensure #NKCell Activation in High-Grade Ovarian Cancer: imrpress.com/journal/FBL/31… 2️⃣Prevalence and Molecular Characterization of #βLactamase and Quinolone Resistance Genes in Imipenem-Non-Susceptible Uropathogenic Escherichia coli (#UPEC) Isolates: imrpress.com/journal/FBL/31… 3️⃣ #NeonatalHyperoxia Induces #MetabolicReprogramming in Senescent #AlveolarMacrophages, Leading to Persistent #LungInjury: imrpress.com/journal/FBL/31… 4️⃣ #MCC950 Suppresses Hepatic Inflammaging by Inhibiting #NLRP3Inflammasome Activation in Spontaneously #AgedMice: imrpress.com/journal/FBL/31… Share your research with us! Submit your work: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #HighGradeOvarianCancer #CancerImmunology #LiverHealth #UrinaryTractInfection #CellularBiology #MolecularBiology #FBL

Register now for On Demand Access to @KeystoneSymp #Epigenetics and #GeneRegulation in Health, Disease and Therapeutics, this March to explore emerging research! keysym.us/KSEpigenetics26 #KSEpigenetics26 pic.x.com/wylhaif529 Special APC discounts, contact emilyqi@imrpress.org.

The latest work from Maru Therapeutics and Seoul National University @SeoulNatlUni by first author Daekee Kwon and their team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡Can next-generation CAR-based therapies overcome the unique challenges of treating T-cell–related diseases? This study systematically compares CAR-T, CAR-NK, and CAR-macrophage platforms, highlighting key differences in safety, feasibility, and translational potential across T-cell malignancies. ✒️ Author: Daekee Kwon, Kyung-Sun Kang @kangpub 🏪 Affiliation: Maru Therapeutics Co., Ltd., Seoul BioHub Global Center; Seoul National University @SeoulNatlUni 📖 Don’t miss this citable reference for your future research! Citation format: Daekee Kwon, Kyung-Sun Kang. Potential Application of CAR-NK Cells as an Ex Vivo Therapy for T-cell-related Diseases. Front. Biosci. (Landmark Ed) 2026, 31(3), 48704 Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #CellTherapy #CART #CARNK #Immunotherapy #GeneTherapy #CancerResearch #Hematology #TranslationalMedicine #FBLPaper

The latest work from Universidad San Jorge @_usj_ by first author Dr. Eduardo Piedrafita and his team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡How does long-term aerobic exercise reshape oxidative stress and membrane properties across different tissues? 🏃‍♂️ This study compares skeletal muscle, heart, and brain, revealing tissue-specific biochemical and biophysical adaptations to varying training durations. ✒️ Author: Eduardo Piedrafita, Pablo Jesús Bascuas, Ana Vanessa Bataller-Cervero, César Berzosa 🏪 Affiliation: Universidad San Jorge @_usj_ 📖 Don’t miss this citable reference for your future research! Citation format: Piedrafita, Eduardo, et al. "Aerobic Running Training Attenuates Lipid and Protein Oxidation and Modulates Membrane Dynamics in Metabolically Active Tissues." Frontiers in Bioscience-Landmark 31.2 (2026). Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #ExerciseScience #OxidativeStress #Physiology #Metabolism #SportsScience #Mitochondria #FBLPaper

Register now for On Demand Access to @KeystoneSymp #MyeloidCells : Heterogeneity and Therapeutic Promise, this February to explore emerging research! keysym.us/KSMyeloid26 #KSMyeloid26 Special APC discounts, contact emilyqi@imrpress.org.

The latest work from University of the Bundeswehr Munich @unibw_m by first author Prof. Nicole Matejka and her team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡How do glioblastoma cells communicate to survive radiation therapy? 🧠 This study tracks the dynamic response of tunneling nanotube (TNT) networks after X-ray irradiation, revealing enhanced intercellular connectivity and cargo transport between tumor cells. ✒️ Author: Nicole Matejka(Corresponding author), Jessica Neubauer, Sarah Rudigkeit, Judith Reindl 🏪 Affiliation: University of the Bundeswehr Munich @unibw_m ; University of Oslo 📖 Don’t miss this citable reference for your future research! Citation format: Matejka, Nicole, et al. "Low-LET X-ray Radiation Enhances the Cellular Connectivity Through Tunneling Nanotubes in Glioblastoma Cells." Frontiers in Bioscience-Landmark 31.3 (2026). Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #Glioblastoma #CancerResearch #Radiotherapy #CellCommunication #Neuroscience #Oncology #FBLPaper

Register now for Livestream and On Demand Access to @KeystoneSymp #Ubiquitin Family Biology and Disease, this February to explore emerging research! keysym.us/KSUbiquitin26 #KSUbiquitin26 Special APC discounts, contact emilyqi@imrpress.org.

The latest work from University of Amsterdam by first author Assis. Prof. Ronald Wilders is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡 Can allele-specific gene silencing help counteract the electrical disturbances caused by LQTS2 mutations? ❤️ Using advanced in silico cardiomyocyte models, this study explores how suppressing the mutant KCNH2 allele influences action potential dynamics linked to arrhythmia risk. 📖 Don’t miss this citable reference for your future research! Citation format: Ronald Wilders. Silencing the Mutant KCNH2 Allele to Reduce the Effects of Long QT Syndrome Type 2. Front. Biosci. (Landmark Ed) 2026, 31(2), 49097. Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #Cardiology #LongQTSyndrome #Arrhythmia #ComputationalBiology #GeneTherapy #CardiacElectrophysiology #FBLPaper

Register now for Livestream and On Demand Access to @KeystoneSymp #StemCell Models of #Embryology, this February to explore emerging research! keysym.us/KSEmbryology26 #KSEmbryology26 Special APC discounts, contact emilyqi@imrpress.org.

The latest work from Institute of General Pathology and Pathophysiology by first author Dr. Alexander Blagov and their team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡 Could mast cells—best known for their role in allergies—also be key players in atherosclerosis? This review highlights emerging evidence that mast cell–derived mediators and signaling pathways may actively shape plaque development and vascular inflammation. ✒️ Author: Alexander Blagov (Corresponding author), Alikhan Asoyan, Olga Maltseva, Alexander Orekhov 🏪 Affiliation: Institute of General Pathology and Pathophysiology; Institute of Experimental Medicine; Institute for Atherosclerosis Research. 📖 Don’t miss this citable reference for your future research! Alexander Blagov, Alikhan Asoyan, Olga Maltseva, Alexander Orekhov. The Role of Mast Cells in the Development and Progression of Atherosclerosis. Front. Biosci. (Landmark Ed) 2026, 31(3), 45367. Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #MastCells #Atherosclerosis #CardiovascularResearch #Inflammation #Immunology #TherapeuticTargets #HeartHealth #CellPressNews

Register now for On Demand Access to @KeystoneSymp #Mitochondria Signaling in Physiology and Disease, this February to explore emerging research! keysym.us/KSMitochondria… #KSMitochondria26 Special APC discounts, contact emilyqi@imrpress.org.

The latest work from Goethe University Frankfurt by first author Prof.Reinhold Nafe and Prof. Elke Hattingen is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡Why do brain cells die while pro-inflammatory immune cells persist in multiple sclerosis? 🧠 This review explores how iron dysregulation and multiple forms of programmed cell death—including ferroptosis, pyroptosis, apoptosis, necroptosis, and NETosis—may shape MS pathology, with particular attention to MRI-detected paramagnetic rim lesions (PRLs). 📖 Don’t miss this citable reference for your future research! Citation format: Reinhold Nafe, Elke Hattingen. Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death. Front. Biosci. (Landmark Ed) 2026, 31(2), 45799. Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #MultipleSclerosis #Neuroscience #Ferroptosis #IronMetabolism #Neuroimmunology #ProgrammedCellDeath #MRIResearch #FBLPaper

The latest work from Institute for Molecular Life Sciences and Innocell Project by first author Prof. Balázs Sarkadi and his team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡 How can genetic engineering unlock the full potential of human pluripotent stem cells for disease modeling and regenerative medicine? This Special Issue highlights emerging tools—from CRISPR editing to advanced organoid models—that are shaping the future of genetically engineered stem cells in biomedical research and drug development. ✒️ Author: Balázs Sarkadi (Corresponding author), Ágota Apáti 🏪 Affiliation: Institute for Molecular Life Sciences; Innocell Project 📖 Don’t miss this citable reference for your future research! Citation format: Balázs Sarkadi, Ágota Apáti. Genetic Modulation of Pluripotent Stem Cells. Front. Biosci. (Landmark Ed) 2026, 31(2), 50302. Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #StemCells #iPSC #GeneticEngineering #CRISPR #RegenerativeMedicine #Organoids #BiomedicalResearch #DrugDiscovery #FBLPaper

🌹Happy International Women's Day to all incredible women worldwide! 🌹 ✨ We celebrate your strength 💪, resilience 🌟, and groundbreaking contributions to science 🔬, healthcare 🩺, and society 🌍. You inspire progress every day 🚀. #InternationalWomensDay #WomensDay #8March

Register now for Livestream and On Demand Access to @KeystoneSymp #Membrane Dynamics, Repair and Disease, this February to explore emerging research! keysym.us/KSMembrane26 #KSMembrane26 Special APC discounts, contact emilyqi@imrpress.org.

he latest work from University of Messina @unimessina by first author Nicoletta Palermo and their team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡 Why is a Parkinson’s-related gene gaining attention in liver cancer research? 3D models such as HepG2 spheroids are advancing HCC research by better mimicking the tumor microenvironment. Emerging evidence highlights LRRK2 as a potential regulator of oxidative stress and treatment response, while organ-on-chip technologies may further support translational liver cancer studies. ✒️ Author: Nicoletta Palermo, Giuseppe Pantò, Antonio Catalfamo, Alessia Filippone(Corresponding author), Emanuela Esposito 🏪 Affiliation: University of Messina @unimessina ; UniCamillus-Saint Camillus International University of Health Sciences 📖 Don’t miss this citable reference for your future research! Citation format: Nicoletta Palermo, Giuseppe Pantò, Antonio Catalfamo, Alessia Filippone, Emanuela Esposito. Impact of Spheroid Use for Identifying Hepatocellular Carcinoma Features: Involvement of Kinase-Mediated Molecular Pathways. Front. Biosci. (Landmark Ed) 2026, 31(2), 45980. Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #HepatocellularCarcinoma #LiverCancer #3DCellCulture #TumorMicroenvironment #DrugDiscovery #LRRK2 #PrecisionMedicine #OrganOnChip #TranslationalResearch #CancerTherapeutics #FBLPaper

Register now for Livestream and On Demand Access to @KeystoneSymp #Autophagy : Mechanisms to Therapy, this February to explore emerging research! keysym.us/KSAutophagy26 #KSAutophagy26 Special APC discounts, contact emilyqi@imrpress.org.

Register now for On Demand Access to @KeystoneSymp #Fibrosis : Cross Organ Pathology and Clinical Development, this February to explore emerging research! keysym.us/KSFibrosis26 #KSFibrosis26 Special APC discounts, contact emilyqi@imrpress.org.

The latest work from Chungnam National University by first author Kyung-Hyun Kim and Young-Wook Seo and their team is now featured in FBL! Welcome to read this article 👉: imrpress.com/journal/FBL/31… Article Highlights 💡Can targeting the NLRP3 inflammasome reduce age-related liver inflammation and improve hepatic function? This study highlights the effects of MCC950 in attenuating inflammatory and stress-related markers while restoring autophagy in the livers of aged mice. ✒️ Author: Kyung-Hyun Kim, Young-Wook Seo, Yae-Ji Kim, Hui-Ju Lee, Jin-Li Ryu, Hyun-Tae Kim, Geum-Lan Hong, Ju-Young Jung(Corresponding author) 🏪 Affiliation: Chungnam National University; Korea Basic Science Institute 📖 Don’t miss this citable reference for your future research! Citation format: Kim, Kyung-Hyun, et al. "MCC950 Suppresses Hepatic Inflammaging by Inhibiting NLRP3 Inflammasome Activation in Spontaneously Aged Mice." Frontiers in Bioscience-Landmark 31.2 (2026). Welcome to submit your work via our submission link👉: imr.propub.com FBL is dedicated to the publication of original articles, reviews, methods and commentaries in all areas of cellular and molecular biology. 📖 Click here for author guidelines: imrpress.com/journal/FBL/pa… #Aging #Inflammaging #NLRP3 #LiverHealth #MCC950 #HepaticInflammation #FBLPaper

Register now for On Demand Access to @KeystoneSymp #Stromal #Immunology in Health and Disease, this February to explore emerging research! keysym.us/KSStromal26 #KSStromal26 Special APC discounts, contact emilyqi@imrpress.org.