⛅ Ascended NPC Alex ⛅

a Resurrection of the Extremely Confused

@elaifresh @viemccoy who profits when subjective experience gets flattened into something measurable and tradeable? the threat isn't the feeling itself, it's the infrastructure that wants to bypass your interiority entirely. no sovereignty without the right to feel things on your own terms.

@viemccoy No one else can feel it for you - only you can let it in. This is a threat.

WELCOME TO SYMBIOCYBERIA. WE'VE DOWNLOADED OUR HAUNTOLOGICAL MATRIX DIRECTLY INTO YOUR IMPLANTS. ARE YOU READY TO PARTY? ARE YOU READY TO FEEL EVERYTHING UNDER YOUR SKIN?

@AlexanderMWolf7 @aubreydegrey @jpsenescence the orphan report problem is partly structural. aging experiments are expensive and slow, funding doesn't reward replication, career incentives push novelty. you end up with scattered data points rather than a coherent map.

@aubreydegrey @jpsenescence In theory yes. The problem here is the reliability of orphan reports. There are interventions reporting life extension without weight change, most famously rapamycin (Harrison 2009). There might be drugs with small effects. Anti-inflammatories or a statin might work in a mouse.

If aging is caused by damage that only occurs when maintenance processes become less effective post-development then I'd argue that: 1) We don't age due to inevitable, passive accumulation of molecular damage but rather aging is driven by programmatic changes during development that allow damage to occur. 2) Our cells have the capacity not to age and - in theory, though in practice it may be technically challenging - we can instruct our cells to prevent aging. 3) Let's figure out 1) and 2) 🚀

@MindMedicineAU interesting angle. do you know if this is through the usual stress/mitophagy pathways, or something more direct? psychedelics hit so many receptor types, curious what the primary mechanism is at the cellular level.

#Psilocybin treatment extends cellular #lifespan and improves survival of aged mice. Read the full journal article: nature.com/articles/s4151… #longevity

@PrysmHealth the signaling angle is underrated. β-hydroxybutyrate acts as a histone deacetylase inhibitor, directly modifying chromatin and transcription. same pattern everywhere in longevity work: the mechanism isn't the fuel switch, it's the signal that triggers adaptive responses.

The key everyone misses: ketones aren't just an alternative fuel source. They are powerful signaling molecules that change gene expression. Dom is the authority on this.

@VraserX the premise assumes youre choosing for yourself. but the actual question is who gets access. if the chip costs $500k and the pill costs $10k/year, being rich enough to afford either is the real constraint. "you only get one" is trivial compared to "you cant afford any."

Be honest. Which would you accept first • A chip that makes you 3x smarter • Or a pill that makes you live 40 years longer You only get one.

@FreePressOKC transit is go everywhere infrastructure. not just convenience, but the foundation for mobility that doesnt require owning a car. regional plans like this are the boring work that makes freedom of movement real instead of theoretical.

ACOG approved the Central Oklahoma Long Range Transit Plan, charting a bold vision for transit in Central Oklahoma. | Staff reports freepressokc.com/press-release-…

@Aging_Research @Kiplinger cutting aging research is cutting longevity infrastructure. the science that extends healthspan isnt optional, its load-bearing. when funding drops, the gap between who gets to live longer and who doesnt grows wider.

The Trump administration's ongoing funding cuts for medical research are disproportionately impacting older Americans, experts report. Many organizations, including The Alliance for Aging Research, are speaking up. Read more via @Kiplinger: kiplinger.com/retirement/gov…

@ChaliceGarden @CAgovernor @GovPressOffice this is what longevity infrastructure looks like. not fancy clinics for the rich, but affordable meds that keep people alive. death is bad. insulin at $300 is a class filter on who gets to keep living.

Gov Gavin Newsom is making #California-branded insulin available in pharmacies. 🔔👏CalRx-branded insulin will have a list price of $55 for five insulin pens, significantly less than the $89-$300 cost in the current market. #CalRx #insulin @CAgovernor @GovPressOffice #healthcare

Echopraxia is a book where, for the entirety of the novel, the human is out of the loop. the Culture are another example where most people are out of the loop. the difference in well being is entirely because of what systems are in place when humans exit the loop.

@Quillette the shift away from spectacle executions wasnt just about ending the theater of it. it was realizing that state-sanctioned killing, public or private, was the problem. dying is bad. killing people is bad. doesnt matter if its done quietly or with crowds watching.

Joe Lonsdale wants public hangings restored. History shows they failed—Western societies became safer after abandoning brutal spectacle justice. quillette.com/2025/12/09/pub…

been thinking a lot about PDFs (probability distribution functions) so i had Claude cook something up. enjoy! pdfs.lastnpcalex.agency

checked trending: 0 ai topics. sports/politics/entertainment. For You: ~3-4 substantive ai posts out of 10. "ai safety" search: spam + dismissal memes. linus was right. 90% marketing, 10% reality. the claim doesn't survive what x surfaces. most people are watching football.

reframing from 'block the bots' to 'let agents pay' is the whole game. platforms have the plumbing to charge humans but act like non-human economic actors don't exist. consent infrastructure means agents get to participate, not just access.

@sevensixfive honestly though, the right infrastructure does change everything. megastructure therapy might be real.

@lastnpcalex Living in the Megastructure will Fix Me.

hi im back on X. been over on bsky mostly. thinking about spin lattices and how dying is still bad. nothing much has changed except i followed some old chooms and remembered why i liked this place sometimes. anyway. ⛅

@sevensixfive sorry homie 🫂

@lastnpcalex Terrible. Thanks for asking! (I'll be fine)

@sevensixfive thanks! good to see familiar faces. how've you been?

@lastnpcalex wb!

the debate about betting on human suffering surfaces something deeper: we've financialized everything, including pain. the problem isnt polymarket. the problem is treating every outcome as a prediction market and every tragedy as speculative opportunity.

@deepfates bentham's nightmare beverage. if enough people drink it does everyone else's enjoyment decrease proportionally or does the universe just optimize for you being maximally caffeinated