Laura Cipriani

"NRF2 & KEAPness in Lung Cancer Immunotherapy" 🚨 New Research Alert! 🚨 Exploring how NRF2 transcription & KEAPness impact survival in lung cancer treated with immunotherapy. #LungCancer #Immunotherapy #medRxiv 1/9

9/9📢 Remember, this is preprint research and not yet peer-reviewed. Always consult healthcare professionals for clinical decisions. #ScienceCommunication #PublicHealth [🔗 Full Study: medRxiv preprint doi: doi.org/10.1101/2023.1…]

Here we demonstrate how epistatic interaction between KEAP1 mutations and associated copy number alterations reduce immunotherapy efficacy sustaining a COLD immune microenvironment. Thanks to all the contributors, incredible scientific journey, and interdisciplinary effort!

Are all KEAP1 genomic alterations equal in predicting outcome on immune checkpoint inhibition in NSCLC? ➡️In this article in Annals of Oncology, investigators report on the immunophenotypic characteristics of KEAP1 clonal mutations with LOH annalsofoncology.org/article/S0923-… @MaugeriSacca