Stefano Scalera

Job opportunity! linkedin.com/jobs/view/3924…

Excited to present TINC (Tumour-In-Normal Contamination, caravagnalab.github.io/TINC/), an open-source tool developed with @GenomicsEngland and @GreatOrmondSt to determine if normal samples are contaminated by tumour cells, using whole genome sequencing! Now in @NatureComms 1/n

Excited to share insights from our #research on Roman #wall #paintings in #Pollena Trocchia, revealing evolving art techniques amidst #Vesuvius #eruptions. #ArtHistory #Analyses🌋

🎨Decoding Colors of the Past! A 2023 ACTA IMEKO paper delves into #pigments from 6th BCE-1st CE of Campania, Italy.🔬Combining #spectroscopy & lab analysis to uncover the artistry & technology behind ancient wall paintings. #ArtMeetsScience #Archaeometry doi.org/10.21014/actai…

9/9📢 Remember, this is preprint research and not yet peer-reviewed. Always consult healthcare professionals for clinical decisions. #ScienceCommunication #PublicHealth [🔗 Full Study: medRxiv preprint doi: doi.org/10.1101/2023.1…]

8/9 🚀 This research opens new avenues in predicting and improving responses to immunotherapy in lung cancer. #Innovation #CancerTreatment

"NRF2 & KEAPness in Lung Cancer Immunotherapy" 🚨 New Research Alert! 🚨 Exploring how NRF2 transcription & KEAPness impact survival in lung cancer treated with immunotherapy. #LungCancer #Immunotherapy #medRxiv 1/9

Here we demonstrate how epistatic interaction between KEAP1 mutations and associated copy number alterations reduce immunotherapy efficacy sustaining a COLD immune microenvironment. Thanks to all the contributors, incredible scientific journey, and interdisciplinary effort!

How do the #genome, #epigenome and #transcriptome co-evolve in colorectal #cancer? In the second of two papers in @nature, we find gene expr is not strongly heritable & evaluate "driverness" of muts directly in patient tumours nature.com/articles/s4158… @AndreaSottoriva #EPICC2 1/7

Super excited to see my first graphical #abstract on the #cover of @JTOonline! The latest review by @stescalera & @MaugeriSacca about the molecular functions of the KEAP1-NRF2 pathway, its role in #lungcancer and how KEAP1/NFE2L2 mutations reduce the efficacy of treatments💊

Review of multifaceted biological functions of the KEAP1/NRF2 pathway in #lungcancer, expected consequences of these alterations, & key clinical studies. Genomic predictors should be conceived relying on the concept of epistatic interactions. bit.ly/3zofJkC #LCSM

Excited to share the new preprint from Fanciulli lab @IREISGufficiale on biorxiv.org/cgi/content/sh… . We wanted to know how Multiple Myeloma cells cope with transcriptional stress, and we found that: Stress UP -> Che-1 / NEAT1 UP -> DNA: RNA hybrids UP -> IFN UP -> Poor prognosis.