Lew Lab @ WashU

Connect with us on #bluesky bsky.app/profile/lewlab… doi.org/10.1038/d41586…

Shooting oneself in the foot? Nope. Shooting oneself in the prefrontal cortex.

For this #SpotlightSunday, view this Spotlight by Matthew D. Lew of #OPG_JOSA_A: Surface orientation ambiguity for single molecules at dielectric interfaces bit.ly/4kh9vJ0 #OrientationImaging #RefractiveIndex @UTArlington

Very happy to share this news of my election to become an #OpticaFellow. I'm grateful to my many students and mentors over the years. Happy Thanksgiving!

How do discoveries in the lab become lifesaving treatments? This updated infographic provides a big-picture view of the R&D pipeline, illustrating the public-private sector continuum from discovery to delivery. It visualizes just how much innovation depends on collaboration among multiple sectors and stages of research. Use this resource in your outreach to show how progress slows when any segment is underfunded or otherwise weakened. #FundScience #MedicalInnovation #HealthResearch

@WashUengineers @WashUESE @NaturePhotonics Happy to share our recent review in @NaturePhotonics on #singlemolecule #orientation #localization #microscopy, co-authored with Sophie Brasselet @CNRS @InstitutFresnel. See molecule motions and rotations in action! doi.org/10.1038/s41566…

Matthew Lew of @WashUESE developed a technique that shows not only where molecules are, but also their orientation in real time. Published in @NaturePhotonics, this breakthrough could transform research on Alzheimer’s, immune response & advanced materials. engineering.washu.edu/news/2025/Wash…

"A new polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM), coupled with engineering insights provided by its imaging model, offers an exciting way forward." My commentary is online in PNAS pnas.org/doi/10.1073/pn…

Congratulations Nadia, @MinaFaragSci and @ahsinchiu! @WashUengineers @WashUESE @WashUBME @WashU

Experiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules. nature.com/articles/s4156…

And read our article here: doi.org/10.1038/s41567… @WashUESE @WashUBME

@WashUengineers @WashUESE This wonderful work was led by @YiyangChen17 , a PhD student in @WashU #ImagingScience Read it here: doi.org/10.1103/PhysRe…

Matthew Lew of @WashUESE & grad student Yiyang Chen developed a new method to improve precision in molecular imaging. Their technique boosts accuracy, with potential to transform studies in protein interactions & more. #WashUEngineers ow.ly/jBBq50VlF0E

This semesters Biophysical Evening seminar will be given by Matthew Lew, Professor in Electrical & Systems Engineering at WashU "Single-Molecule Orientation-Localization Microscopy: New Challenges and Biophysical Insights" Thurs, March 20th 4-5 PM, Connor Auditorium

Out today from the Lee lab @SteveTheChemist In the POLCAM paper, they make polarization cameras compatible with single-molecule detection for instant molecular orientation microscopy. nature.com/articles/s4159…

@SteveTheChemist @BruggemanEzra @naturemethods @rita_strack @ChemCambridge Congratulations @BruggemanEzra and @SteveTheChemist ! Beautiful work, and thanks for letting us be a part of it!

Huge Congratulations to @BruggemanEzra and all others, her latest work on single-molecule orientation imaging published in @naturemethods. Huge Effort. Many thanks for @rita_strack for facilitating. @ChemCambridge nature.com/articles/s4159…

News coverage of our JPC article pubs.acs.org/doi/10.1021/ac… "Wobbly molecules get a closer look" engineering.wustl.edu/news/2024/Wobb… via @WashUengineers @shawncballard

We made the cover! Check out Weiyan's work exploring the "Fundamental Limits in Measuring the Anisotropic #RotationalDiffusion of #SingleMolecules" in @JPhysChem doi.org/10.1021/acs.jp… @WashUESE @WashUengineers

Brian's study on using the #binding #orientations of Nile blue to decipher the architectures of growing, decaying, and remodeling #amyloid #fibrils is now online in @NanoLetters ! #singlemolecule @WashUESE @WashUengineers doi.org/10.1021/acs.na…

Congratulations Dr. O! @wuimgsci_stuco @WashUengineers

Our work with @JaiRudra4 is online here pubs.acs.org/doi/10.1021/ac…