LewisLabUCSD

What you eat, given your microbiome, can affect your response to drugs without altering the drug (at least if you're a worm). Great collaboration with the O'Rourke lab nature.com/articles/s4146…

Our 14 protein knockout cell line work was highlighted in GenEng News: "Genome Editing Helps Cell Lines “Clean Up” Their Protein Production" @favprotchemist @Danielley86DK @GutierrezJahir @wtchiang2013 @DTUBiosustain genengnews.com/news/genome-ed…

Latest work from @Anne_R1chL. We developed a tool that used systems biology models to precompute the genes needed for a cell to accomplish a metabolic task, and now you can overlay your omics data to see what your cell is doing using @GenePattern. bioRxiv: doi.org/10.1101/2020.0…

Standard bioinformatic pipeline twitter.com/AMAZlNGSCIENCE…

@GutierrezJahir and @amir_feizi mapped out the mammalian secretory pathway, connected it to a genome-scale metabolic model, and showed we could predict an increase in antibody secretion with a gene knockdown. @NIGMS @DTUBiosustain nature.com/articles/s4146…

Making Goodsell illustrations sciencedirect.com/science/articl…

@Nathan_E_Lewis This is soooo cool!

Will Johnson from @Amgen presenting on multivariate, multi-scale, modular modeling of bioprocessing at #BPSMT. From bioreactor fluid dynamics to cellular metabolism to subcellular organs. Cool stuff!

Mortiz von stosch from #Glaxo on ML applications in bioprocessing: ready-now (concise problem with lots of data) versus ready-later (hybrid models with broad implications). #ArtificialIntelligence #BPSMT See also: aiche.org/chenected/2014…

Enjoyed your talk and exciting results with the Beacon technology #BPSMT

UCB researcher Dr. Rana Sidhu spoke today at the @CHI_Healthtech #BPSMT event about the new strategies our scientists are using to better understand proteins that are challenging to study: ucbusa.news/2YXoOPP

Enjoyed Jamey Young's CHO productivity and mitochondrial metabolism presented at the Bioprocessing Summit! #BPSMT @VUEngineering

Enjoyed you guys' booth at the Bioprocessing Summit! (#BPSMT)

Hooman will be presenting on the "Complete Elimination of the Warburg Effect in CHO Cells", this Thursday at the Bioprocessing Summit (#BPSMT). Come join!

Just came out today... by targeting two transcription factors concurrently, we engineered innate immunity in mammalian cells to make them resistant to multiple RNA viruses: rdcu.be/bHkX5

We engineered cleaner drug producing mammalian cells by knocking out more than a dozen genes, leading to better growing cells, enhanced recombinant protein production, and more pure antibody production. Check out our preprint: biorxiv.org/content/10.110…

Congrats to Julie la Cour Karottki @kjlack, our adopted lab member, for an excellent PhD thesis defense on the use of #CRISPR a/i and pooled screens in CHO cells! @DTUBiosustain

A new, experimentally defined annotation of the Chinese hamster genome, plus the identification of endogenous retroviral elements that have added a significant cost to biopharmaceuticals for decades pubs.acs.org/doi/10.1021/ac…

A computer model attempts to simulate the metabolic network of a minimal cell with 493 genes elifesciences.org/digests/36842/…