Gan Lab

1K posts

Gan Lab banner
Gan Lab

Gan Lab

@LiGanLab

We've moved to Bluesky! Please follow us there! https://t.co/pbbp33G3QU

New York Katılım Temmuz 2019
528 Takip Edilen4.1K Takipçiler
Sabitlenmiş Tweet
Gan Lab
Gan Lab@LiGanLab·
Our new study online today @MolNeuro shows that microglial DAP12 controls tau buildup and drives myelin loss by mediating a harmful tau-induced SLIT2 signal from neurons to oligodendrocytes link.springer.com/article/10.118…
English
1
7
29
2.3K
Gan Lab
Gan Lab@LiGanLab·
In our latest preprint, we show microglia protect against levodopa-induced dyskinesia (LID): microglia-derived sTREM2 acts on TrkB, boosts BDNF-TrkB signaling, and points to plasticity as a potential Parkinson’s/LID therapy biorxiv.org/content/10.648…
English
2
3
11
977
Gan Lab
Gan Lab@LiGanLab·
Excited to share our spotlight article in Cell Stem Cell on CAR-A astrocyte therapy for Alzheimer’s disease, an innovative approach for in vivo amyloid clearance. We discuss both the promise and the challenges ahead. 🧠 sciencedirect.com/science/articl…
English
2
3
14
1.1K
Gan Lab
Gan Lab@LiGanLab·
New in Nature: de Faria et al. show focal white matter lesions trigger remote microglial response to demyelinated neurons in grey matter, which is required for remyelination. Deplete grey matter microglia→repair failures→chronic grey matter inflammation doi.org/10.1038/s41586…
English
1
4
29
1.8K
Gan Lab
Gan Lab@LiGanLab·
Check out our earlier work: Immunotherapy targeting AcTau174 improves cognition in mouse models of TBI & tauopathy, establishing AcTau174 as a driver of cognitive decline link.springer.com/article/10.118…
Gan Lab tweet media
English
1
0
0
188
Gan Lab
Gan Lab@LiGanLab·
New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment nature.com/articles/s4159…
Gan Lab tweet media
English
2
7
29
2.2K
Gan Lab
Gan Lab@LiGanLab·
Paquet lab addresses iPSC limitation: new line with endogenous P301L/S320F 4R tau develops age-related tauopathy phenotypes stem cells typically fail to model. Platform shows pathological tau aggregation for more precise tauopathy research & drug screening science.org/doi/10.1126/sc…
English
1
3
20
2.1K
Gan Lab
Gan Lab@LiGanLab·
MAPT p.R406W disrupts autophagy–lysosome pathway, impairing Tau degradation. Mutant neurons accumulate Tau/pTau in lysosomes, impairing motility, fusion, & clearance. Autophagy enhancement lowers Tau & restores degradation but doesn't rescue trafficking nature.com/articles/s4146…
English
1
10
25
2.3K
Gan Lab
Gan Lab@LiGanLab·
The 13th Annual Appel Symposium on Mar 24 spotlighted the interconnectedness of neurodegenerative diseases. Drs. Sreeganga Chandra (Yale), Eddie Lee (UPenn), & Anna Orr (Appel) gave keynote presentations, preceded by over two dozen trainee posters from Appel & collaborating labs
Gan Lab tweet mediaGan Lab tweet mediaGan Lab tweet mediaGan Lab tweet media
English
1
2
10
994
Gan Lab
Gan Lab@LiGanLab·
PanNDA leverages deep proteomics of 2,279 human brain samples (AD, LBD, FTD-TDP-43, PSP, VD, & PD) to reveal shared disease mechanisms, spotlighting GPNMB (microglial/lysosomal activation) & NPTX2 (synaptic regulation). Data: penglab.shinyapps.io/pannda Paper: cell.com/cell/fulltext/…
English
1
2
17
1.1K
Gan Lab
Gan Lab@LiGanLab·
18 protein panel captures CSF microglia innate immune & cellular recruitment dynamics across AD stages, from preclinical to dementia. Protein profiles track disease progression & could serve as biomarkers for microglia-directed therapeutic interventions #Abs1" target="_blank" rel="nofollow noopener">link.springer.com/article/10.103…
English
2
13
30
2.9K
Gan Lab
Gan Lab@LiGanLab·
Key insights for microglial therapeutic strategies: Phase 2 trial of TREM2 agonistic antibody AL002 in early AD reduced soluble TREM2 & increased osteopontin in CSF but failed primary cognitive endpoint. ARIA-like MRI abnormalities observed nature.com/articles/s4159…
English
2
0
4
542

Keşfet

@elonmusk @BarackObama @taylorswift13 @cristiano @BillGates @NASA @nikifrancismediavine @katyperry