Gan Lab

Our new study online today @MolNeuro shows that microglial DAP12 controls tau buildup and drives myelin loss by mediating a harmful tau-induced SLIT2 signal from neurons to oligodendrocytes link.springer.com/article/10.118…

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Key insights for microglial therapeutic strategies: Phase 2 trial of TREM2 agonistic antibody AL002 in early AD reduced soluble TREM2 & increased osteopontin in CSF but failed primary cognitive endpoint. ARIA-like MRI abnormalities observed nature.com/articles/s4159…

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New in Science, Cao lab created a single-cell atlas spanning 21 mouse tissues over 3 age groups. Analysis shows broad changes in cellular composition, chromatin accessibility, & transcription factors in immune cells particularly & major sex differences science.org/doi/10.1126/sc…

Congratulations, Nessa Foxe, on receiving the Frank & Blanche Mowrer Memorial 2025-2026 WCGS Merit Fellowship! Nessa is a graduate student in our lab & this award recognizes her for her outstanding productivity & academic record. We couldn't be more proud!

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Excited to share our preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS biorxiv.org/content/10.648…

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McGavern lab discovers dural venous sinuses are active neuroimmune interfaces. Fenestrated endothelial cells dynamically open/close borders (RAMP2 dependent) to balance fluid exchange with immune cell trafficking. Disruption compromises antiviral immunity nature.com/articles/s4158…

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Lu lab shows tumor-derived cystatin-C attenuates AD amyloid pathology by acting as molecular glue between microglial TREM2 & amyloid oligomers. This study links cancer biology & AD, spotlighting therapies aimed at clearing existing amyloid plaques cell.com/cell/fulltext/…

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PtdIns(3,5)P2 identified as endogenous lipid ligand of STING, cooperating with cGAMP to promote STING oligomerization, ER-Golgi trafficking, & TBK1 activation. PIKfyve–PtdIns(3,5)P2–STING axis is critical lipid-based mechanism for innate immune signaling nature.com/articles/s4158…

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We identify microglial cGAS-STING-IFN is key accelerator of drug-refractory epilepsy in Dravet model. Neuronal hyperexcitability releases DNA that activates microglial cGAS. Pharmacologic cGAS inhibition reduces heat-induced seizures & premature mortality biorxiv.org/cgi/content/sh…

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DeepMind debuts AlphaGenome to predict functional genomic features from DNA sequences at single-base resolution. Capturing long-range context, AlphaGenome excels at estimating how genetic variants affect gene expression, splicing, & chromatin accessibility nature.com/articles/s4158…

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New study in Nat Neurosci finds TGFβ signaling is crucial for maintaining microglial resilience to myelin degeneration in spinal cord dorsal column during aging & emergence of TGFβ signaling-sensitive microglial & disease-associated oligodendrocyte subsets nature.com/articles/s4159…

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Excited to share our new study identifying soluble DLK1 as a novel microglia-derived senescence factor. sDLK1 induced hypomyelination, oligodendrocyte dysfunction, & altered neuronal activity in iPSC-derived neurons @TheodorisLab @dsrivastava_md biorxiv.org/content/10.648…