Gan Lab

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Gan Lab

Gan Lab

@LiGanLab

We've moved to Bluesky! Please follow us there! https://t.co/pbbp33G3QU

New York Katılım Temmuz 2019
524 Takip Edilen4.1K Takipçiler
Gan Lab
Gan Lab@LiGanLab·
Excited to see this comprehensive review published in Cell by Dr. Holtzman @holtzman4 and colleagues, highlighting the latest advances in Alzheimer's disease and outlining key challenges and opportunities for the field. cell.com/cell/fulltext/…
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Gan Lab
Gan Lab@LiGanLab·
Preprint⚠️: Using HuMiNAX, an in vivo human iPSC neuroimmune chimera model of tauopathy, we show tau seeds drive neuronal loss, PGRN overexpression in microglia lowers inflammation & protects neurons, & a human neuronal lncRNA pathway mediates degeneration biorxiv.org/content/10.648…
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Gan Lab
Gan Lab@LiGanLab·
Our new JCI review discusses the cGAS-STING pathway's evolution & molecular roles beyond inflammation & highlights how activation affects glial states, neuronal homeostasis, & BBB integrity, yielding new therapeutic paths in neurodegenerative disease pubmed.ncbi.nlm.nih.gov/42222892/
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Gan Lab
Gan Lab@LiGanLab·
Lu et al. profiled >10,000 plasma & CSF samples to uncover how APOE2 & APOE4 confer divergent AD risk. APOE2 protects by sustaining homeostatic & anti-inflammatory signatures before Aβ accumulation, whereas APOE4 proteomic changes respond after pathology nature.com/articles/s4358…
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Gan Lab
Gan Lab@LiGanLab·
Gan lab takes on Central Park zoo! Groups ideated, wrote and shot 2-4min short videos about intriguing CP zoo lore last Friday. Awesome time storytelling and collaborating with everyone!
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Gan Lab
Gan Lab@LiGanLab·
In our latest preprint, we show microglia protect against levodopa-induced dyskinesia (LID): microglia-derived sTREM2 acts on TrkB, boosts BDNF-TrkB signaling, and points to plasticity as a potential Parkinson’s/LID therapy biorxiv.org/content/10.648…
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Gan Lab
Gan Lab@LiGanLab·
Excited to share our spotlight article in Cell Stem Cell on CAR-A astrocyte therapy for Alzheimer’s disease, an innovative approach for in vivo amyloid clearance. We discuss both the promise and the challenges ahead. 🧠 sciencedirect.com/science/articl…
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Gan Lab
Gan Lab@LiGanLab·
New in Nature: de Faria et al. show focal white matter lesions trigger remote microglial response to demyelinated neurons in grey matter, which is required for remyelination. Deplete grey matter microglia→repair failures→chronic grey matter inflammation doi.org/10.1038/s41586…
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Gan Lab
Gan Lab@LiGanLab·
Check out our earlier work: Immunotherapy targeting AcTau174 improves cognition in mouse models of TBI & tauopathy, establishing AcTau174 as a driver of cognitive decline link.springer.com/article/10.118…
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Gan Lab
Gan Lab@LiGanLab·
New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment nature.com/articles/s4159…
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