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@BiuChemistry
@ubarilan
עברית
Liel Sapir
1.2K posts
Liel Sapir
@LielS5
Biophysics, Polymers, and Physical Chemistry | #newPI at the Department of Chemistry, @ubarilan
Jerusalem, Israel Katılım Aralık 2018
1.1K Takip Edilen306 Takipçiler
Liel Sapir retweetledi
Liel Sapir retweetledi
Happy to share our latest publication in ChemPhysChem! In this work, we investigated the P. aeruginosa copper transcription factor and show that it binds different promoters with different affinities, leading to different functional outcomes.
…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cp…
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Liel Sapir retweetledi
Amen! To all my Iranian friends. I wish and pray you will get your country back. I am sending you a big hug, I hope your families are okay. Rid the Middle East from the plague that is the Ayatollah.
Judea Pearl@yudapearl
The Ayatollah’s Regime Is Crumbling No matter what happens now, there is no scenario in which the Islamic Republic survives 2026 with its power intact. thefp.com/p/the-ayatolla…
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I've been wanting to collaborate with @DvirGur for years now, because he's such a brilliant experimentalist!
Now we finally got to do it! Read the paper below 👇
As an added bonus - it is also my first paper ever with @LielS5, my good friend since undergrad!
@chemistrytau
Dvir Gur@DvirGur
How do you tell a molecular crystal how to grow? In materials science, crystal morphology is usually an outcome. In biology, it’s often a design feature, tuned to deliver specific optical and other functional properties. In our new paper in Small, we dissect how crystal growth can be steered at the molecular level, and show that simple synthetic polymers can not only reproduce biogenic plate-like morphologies, but also expand the accessible shape space. By systematically varying polymer chemistry, we uncover three key principles: • Multivalent interactions are important for sustained growth control • Carbonyl-bearing functional groups selectively adsorb to the crystal stacking face, suppressing growth along the stacking direction • Subtle changes in polarity and sterics redirect growth into plates, prisms, or even needle-like morphologies This work was led by Dolev Brenman-Begin, who submitted her first first-author manuscript just before giving birth, and then handled the revisions with a newborn at home. A remarkable scientific and personal milestone. 💪🏽 The study was a close collaboration with (@barak_hirshberg) Barak Hirshberg‘s lab and his talented postdoc Jonatan Church (Tel Aviv University), and with (@LielS5) Liel Sapir Sapir’s lab (Bar-Ilan University). Other authors and collaborators - thank you all: Siddharth Sahoo, (@ZoharEyal1) Zohar Eyal , (@IdanBiran) Idan Biran, PhD , Nir Kampf, (@yuval_barzi) Yuval Barzilay, Anna Kossoy-Simakov, Lothar Houben. @WeizmannScience onlinelibrary.wiley.com/doi/10.1002/sm…
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Congratulations @DvirGur and @barak_hirshberg !!! I had a great fun collaborating on this!
Dvir Gur@DvirGur
How do you tell a molecular crystal how to grow? In materials science, crystal morphology is usually an outcome. In biology, it’s often a design feature, tuned to deliver specific optical and other functional properties. In our new paper in Small, we dissect how crystal growth can be steered at the molecular level, and show that simple synthetic polymers can not only reproduce biogenic plate-like morphologies, but also expand the accessible shape space. By systematically varying polymer chemistry, we uncover three key principles: • Multivalent interactions are important for sustained growth control • Carbonyl-bearing functional groups selectively adsorb to the crystal stacking face, suppressing growth along the stacking direction • Subtle changes in polarity and sterics redirect growth into plates, prisms, or even needle-like morphologies This work was led by Dolev Brenman-Begin, who submitted her first first-author manuscript just before giving birth, and then handled the revisions with a newborn at home. A remarkable scientific and personal milestone. 💪🏽 The study was a close collaboration with (@barak_hirshberg) Barak Hirshberg‘s lab and his talented postdoc Jonatan Church (Tel Aviv University), and with (@LielS5) Liel Sapir Sapir’s lab (Bar-Ilan University). Other authors and collaborators - thank you all: Siddharth Sahoo, (@ZoharEyal1) Zohar Eyal , (@IdanBiran) Idan Biran, PhD , Nir Kampf, (@yuval_barzi) Yuval Barzilay, Anna Kossoy-Simakov, Lothar Houben. @WeizmannScience onlinelibrary.wiley.com/doi/10.1002/sm…
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Liel Sapir retweetledi
On March 9-12, @TelAvivUni will host an incredible workshop, "Stochastic Dynamics in Natural and Artificial Systems." I am extremely excited to speak at a conference honoring a giant of Israeli science, Yossi Klafter. Join us! (free, registration required)
docs.google.com/forms/d/1nEt7i…
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Liel Sapir retweetledi
IPPS 2026 | המקום שבו מחקר פוגש תעשייה
הכנס ה־51 של החברה הישראלית לפולימרים ופלסטיקים יפגיש בין חוקרים, מהנדסים ואנשי תעשייה ליום של ידע, חדשנות וחיבורים משמעותיים.
📅 7.1.2026 | אקספו תל אביב
👉 הרשמה כאן:
israelipolymer51.com
עברית
@e_saady @NairoukhGroup Thank you Zack for coming! It was a pleasure!
English
A great pleasure hosting @NairoukhGroup today! Really enjoyed his fascinating talk on regioselective substitution and dearomatization of pyridine derivatives. Thanks Zack for coming and looking forward for more exciting chemistry to come!
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Late registration still available: israelipolymer51.com/registration/
English
Excited toward the upcoming meeting of The Israeli Polymers & Plastics Society - IPPS 2026.
Especially thrilled to chair the polymer physics session, with invited talks by Valeriy Ginzburg, Michael Silverstein, Yitzhak Rabin, David Andelman, and Yachin Cohen!!!
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Liel Sapir retweetledi
Check out our new preprint: Dynamics of Ligand Binding Sites and Chloride Penetration in a Bitter Taste GPCR biorxiv.org/content/10.110… by Alon Rainish and Liel Sapir
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This mechanism resolves the long-standing gap between chain stretching experiments and scattering measurements of dilutes solutions. We also provide a simple crossover function, validated by simulations, for the Kuhn length as a function of applied force.
2/2
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Thrilled to share our new ACS Macro Letters publication!!! @ACSMacroLett
We uncover how stretching a polymer chain suppresses long-range intramolecular correlations, causing the effective Kuhn length to decrease with applied force.
pubs.acs.org/doi/10.1021/ac…
1/2
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Incredibly honored to be selected as the recipient of 2026 APS John H. Dillon Medal. This would not be possible without tremendous support of advisors and mentors, UVA SEAS and leadership, polymer physics community, funders, and most of all, students and postdocs who did the work
English
Our recent publication together with @Saxena_Lab and @LielS5. Wonderful work of Yasmin Igbaria-Jaber (@BiuChemistry ) and @AlysiaMandato
on applying EPR spectroscopy to study protein oligomerization in solution
onlinelibrary.wiley.com/doi/10.1002/pr…
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@sharonruthstein @Saxena_Lab @BiuChemistry @AlysiaMandato It was a pleasure to contribute to this great research!
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In materials science, crystallization is usually driven by supersaturation and tuned by factors like temperature and solvent composition. In biology, however, crystals must form under physiological conditions and ambient temperatures, which drastically narrows the “playground” for crystallization.
In our new study, just published in @nchembio, we used zebrafish crystal-forming cells as a model to uncover what drives biogenic crystal formation - and found that pH dynamics play a central role.
By integrating cryo-electron microscopy, spectroscopy, and pharmacological perturbations, we revealed how the iridosome microenvironment orchestrates guanine crystal formation. Early-stage iridosomes are highly acidic, which likely facilitates the buildup of protonated amorphous guanine and the assembly of macromolecular scaffolds. As the organelles mature and crystals expand, the pH gradually neutralizes, enabling further growth. When these pH changes are disrupted, crystal formation is severely impaired, highlighting the importance of tightly regulated organellar environments in biological crystallization.
This work was brilliantly led by @ZoharEyal1 , together with @RachaelDeis and Anna Gorelick Ashkenazi, and made possible through the contributions of many wonderful collaborators and friends: @yuval_barzi, Yonatan Broder, @KellumAshe74214, @NetaVarsano, Michal Hartstein, Andrea Sorrentino, Ron Rotkopf, Ifat Kaplan-Ashiri, Katya Rechav, Rebecca Metzler, Lothar Houben, Leeor Kronik, Peter Rez.
#Crystallization, #Biomineralization, #MaterialsScience, #CellBiology, #StructuralBiology, #CryoEM, #Spectroscopy, #Zebrafish
Check it out:
nature.com/articles/s4158…
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We are looking forward Shahar!!!!! Very glad that you are joining! :)
Shahar Dery@ShaharDery
Thrilled to announce that this October I will be joining the Department of Chemistry at Bar-Ilan University as an Assistant Professor! 🧪✨ Our lab is already under construction! Looking forward to building a team to explore the exciting interface of catalysis and spectroscopy.
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