Christian Bache Billesbølle

Happy New Year! Excited to share the final version of our work where we combine deep mutational scanning, cryo-EM, and molecular dynamics to further resolve the mechanisms of pH sensing in GPCRs. 🧵(1/n) cell.com/cell/fulltext/…

Our continued interrogation of how odorant receptors decipher a huge diversity of odorants. Started with a cold email to Hiro Matsunami, which led to a brilliant collaboration with @Sci_CadM, @VaidehiLab, @LleBillesb, Ning Ma and others. biorxiv.org/content/10.110…

A fun collaboration with labs of @gwrud, @BShoichet, Basbaum, Wetsel, and @zenbrainest cell.com/cell/fulltext/…. @LleBillesb obtained the cryo-EM structure to validate the docking. Docking can find new molecules with cool activity for intensely studied targets like SERT!

Wonderful to see this finally in print! Congrats to @BShoichet lab, @AashishManglik lab, Rudnick lab @YaleMed Wetsel lab @PsychoMouse @ahuangxp and many, many others.. Perhaps even clinically relevant path forward! cell.com/cell/fulltext/…

Excited to share the last part of my PhD work, where we track co-receptor signaling dynamics during B cell activation! Great collaboration with @KalocsayMarian biorxiv.org/content/10.110…

new release4 8F76: Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 Manglik lab. Nature.

Beautiful, elegant and revealing structure of an odorant receptor bound to propionate showing somewhat different activation mechanism to other Class A GPCRs nature.com/articles/s4158…

📰Check out our latest work from @LabSkiniotis on "Time-resolved cryo-EM of G protein activation by a GPCR" that is now on @biorxivpreprint!👀 #GPCR #cryoEM [a thread w/ videos below] (1/6) biorxiv.org/content/10.110…

@SimonFoster_PhD @AashishManglik Thanks @SimonFoster_PhD !

So cool to see an odorant receptor structure!! Especially for one that is expressed in tissues beyond the nose! Congrats to Christian @AashishManglik and the team! 👏 nature.com/articles/s4158…

I have committed my scientific career in studying the regulation of these genes; reading this manuscript is extremely fulfilling. I know first hand how hard it is to accomplish what these scientists accomplished. Bravo!nature.com/articles/s4158…

.@UCSF scientists have created the first molecular-level, 3D picture demonstrating how odor receptors allow us to detect scent. “This has been a huge goal in the field for some time,” @AashishManglik says. ucsfh.org/3JVP0kF

Often a major scientific discovery can be boiled down to a single plot in a paper. Lane 13 is the 1991 discovery of vertebrate odorant receptors by Linda Buck and Richard Axel @NobelPrize PMID: 1840504

new release1 Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl Manglik, Shoichet, and Rudnick labs.

Wow!! nature.com/articles/s4158…

FIRST STRUCTURE OF A VERTEBRATE ODORANT RECEPTOR!!! 32 years after they were cloned by Buck and Axel. Amazing.

The molecular basis of the #autoimmune condition #GravesDisease has been a mystery for decades. Now in @Nature, a collab btwn the @ucsf labs of Biohub Investigator @AashishManglik & @yifan_ucsf has finally solved it. nature.com/articles/s4158… 1/7

Thanks @czbiohub for highlighting our work! Led by @Bryan__Faust and @LleBillesb in my lab, this paper has been a labor of love since I started my lab in 2016. Was fortunate to collaborate with @yifan_ucsf, who held our hand as we slowly learned #cryoEM.