Lucas Pontel

Check out our latest review in @MolecularCell! We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis. 👏Terrific job by the talented #MartaValverde @CarrerasIJC 📰👉authors.elsevier.com/a/1lDFm3vVUPVa… cell.com/molecular-cell…

People often ask how breakthroughs occur in cancer biology-often the story is more complex - the survival plot for myeloma outcomes is extraordinary - improvements come about in incremental steps - in my lifetime treatment of Myeloma has almost transformed into a curable disease

📢 PhD Call – Severo Ochoa Doctoral Fellowships A great opportunity for early-stage researchers 👉 careers.carrerasresearch.org/jobs/7413843-v… 🔬 Interdisciplinary scientific training 🧪 Access to cutting-edge technologies 📍International environment based in Barcelona 📅 4 years

New GROUP LEADER POSITION announced @IRBBarcelona !!! This one is for CHEMICAL BIOLOGY 🧪! Chemists apply👩🏻‍🔬👨🏽‍🔬🧑🏻‍🔬!!!! recruitment.irbbarcelona.org/jobs/7334978-g…

¿De dónde venimos? Antes de ayer, en el #DarwinDay, el grupo de P. Holliger (a quien conozco bien), publicó este artículo FUNDAMENTAL para el #MundoRNA y el #OrigenDeLaVida: ¡una ribozima de 45 nt capaz de auto-replicarse! Seguiremos informando 😉 science.org/doi/10.1126/sc…

Returning home after a fruitful and intense visit to #WIMM @UniofOxford @ketanpatelimmo1. Looking forward to strengthening our research @CarrerasIJC with new ideas and collaborations!

Formaldehyde: a genotoxin today but possibly a creator billions of years ago. Asteroid Bennu sample analysis reveals biologically relevant sugars produced via formaldehyde-driven prebiotic reactions. nature.com/articles/s4156…

Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)

@RosadoLab Felicitaciones Ivan!!! Por muchos mas éxitos!!! 👏👏👏🎉🎉🎉

Yesterday, I was appointed Associate professor!! Yayyy!! Thank you to everyone involved!!

Hoy, Día Internacional de la Investigación contra el Cáncer, queremos recordar que cada avance científico abre una puerta a la esperanza. Gracias a la investigación, miles de pacientes tienen nuevas oportunidades y mejores tratamientos. 💜 #investigacioncancer #anemiadefanconi

🔬 On #WorldCancerResearchDay, our Director Dr. Ari Melnick reaffirms our commitment to everyone fighting this disease. 🎯 Our mission is clear: to eradicate blood cancers. 🚀 We are moving toward a new era in medicine. 🩵 Together, we are unstoppable.

Totalmente de acuerdo con @RogerJDavis1 “una de las cosas importantes ahora mismo es sostener la ciencia básica y aprender cosas nuevas, son esas cosas nuevas las que van a ser revolucionarias. No va a ser la aplicación del conocimiento que tenemos ahora” elpais.com/salud-y-bienes…

✨ Young talent, big ideas! At today’s #YoungResearchersSeminars, 👩‍🔬Marta Valverde (@LucPontel lab) shared her work on bone marrow failure and leukemia predisposition 🩸, and 🧑‍💻Marc Escobosa (@eportacangen lab) presented new insights into bladder cancer immune interactions 🧬

@raffcolo Indeed, blood steady formaldehyde concentrations are overestimated, more likely around 1-5uM than 100s. The main support for biological relevance comes from patients lacking FA detoxification and mouse genetic models, who develop severe phenotypes. cell.com/molecular-cell…

Finally, they speculate that hydrogen peroxide and formaldehyde can cause inflammation and crosslinking. While no hydrogen peroxide is actually formed, formaldehyde is indeed a metabolite and so warrants further discussion.

Sloot et al. published a paper proposing a putative mechanism for ILD, suggesting the involvement of a specific component of the DXd linker (the hemiaminal)   While an understanding of how ADCs can cause ILD is lacking, their explanation has several issues!   A thread 🧵👇

Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: …cancer-center-careers.hctsportals.com/jobs/1883440-t…

En tan solo un mes, tendrá lugar el XII Congreso Fundación Anemia de Fanconi. 📣 Recuerda que, si aún no te has inscrito, puedes hacerlo a través del formulario que encontrarás en: sevilla.congresoseci.com/anemiafanconi2…

Our @CarrerasLeaders fellow #NatiAlquezar setting up everything to test #Recipher @lucidsci to understand long-term metabolic changes in AML in response to therapy 💊🧫🧬🩸 @CarrerasIJC

@JoseL_Sardina @ScienceAdvances Terrific work Jose and team! Big big congrats 👏👏

1/ Can we control how cells sense external stimuli by modulating their epigenetic states? 🧬🧪 Our latest study shows that targeted DNA methylation editing can shape cell fate & inflammatory responses in immune cells-now out in @ScienceAdvances! 👇 science.org/doi/10.1126/sc… 🧵:

📢 New #PhD Opportunity! Join the Cancer Metabolism group, led by @LucPontel, and help to develop innovative therapeutic strategies to prevent #leukaemia onset. #JobOffer 🔗 Apply until 31 July 👇 careers.carrerasresearch.org/jobs/6132616-v…

Si no conseguistes un contrato FPU 2025, pero sigues interesado en realizar una tesis doctoral, contacta con nosotros para solicitar un contrato del Plan Propio de Investigación de la U. Sevilla. Unete a nosotros!! tvirtual.us.es/teous-rest-api…