Luisi-Lab

Super-strained spirocycles meet AI-supported target fishing. ⏹️🤝🎣 We introduce a new class of "super-strained" spirocycles which through AI-supported target fishing (@CASChemistry) were found to be agonists for the sigma-1 receptor. 💊 Now in @angew_chem Link in comments👇

A novel and sustainable continuous-flow approach for atom deletion and insertion by electrophilic nitrogen transfer - now published in Green Chemistry pubs.rsc.org/en/content/art…

If strained spiro heterocycles have caught your attention, wait until you meet their "super-strained" counterparts. Full disclosure of results soon - stay tuned!! 🔜 @Luisi_Lab @SusPharma_eu

🚀 @Luisi_Lab is supporting applications for a MSCA Fellowship! Join us to develop your own project with a strong focus on knowledge exchange in: 🔬 Flow chemistry | 💡 Photochemistry | 🤖 AI-driven drug discovery 📍 Bari, Italy 🌊☀️ 📩 Send your CV+project idea to @Luisi_Lab

Excited to share our Chem. Soc. Rev. paper on greener-by-design fine chemicals! 🌱🌱 A joint effort by Italian, German, British, Slovenian & Belgian teams. Congrats to PhD student Jonas Wuyts (ORSY) & all co-authors! pubs.rsc.org/en/content/art… Check out the front cover!

🔬Modular access to spiro[2.3]hexanes! New sulfonium salts enable JCC-type reactions to build oxa- & diazaspiro[2.3]hexanes-rigid, sp³-rich bioisosteres. 🚀Supported by in silico prediction + in vitro validation by @Luisi_Lab - @angew_chem - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/an…

📄New Preprint: We report a radical disconnection strategy that enables the direct, single-step, photocatalytic conversion of α-amino acids into differentiated vicinal diamines. Broad scope, functional-group tolerant, and scalable in flow. 🔗@ChemRxiv: chemrxiv.org/engage/chemrxi…

🔔Interested in strained spirocycles as potential bioisosteres? 🔔 Our recent @angew_chem describes our approach for the modular synthesis of spiro[2.3]hexanes and our in silico & in vitro investigation of their potential bioisosterism! @Luisi_Lab onlinelibrary.wiley.com/doi/10.1002/an…

An interesting skeletal construction method published in Nature: nature.com/articles/s4158… A similar approach, published 75 years ago, still seems to be more convenient (although may be less tolerant): orgsyn.org/demo.aspx?prep…

After 50 years, radical chemistry returns to Italy! 🇮🇹 Bologna will host 𝗜𝗦𝗢𝗙𝗥-𝟭𝟰 (7–10 Jun 26), the international symposium on free radicals Cutting-edge science, world leaders, and unforgettable radical chemistry! 🔗isofr14.it #ISOFR14 #Chemistry #Radicals

Just wrapped up JISOC2025 — the Japanese–Italian Symposium on Organic Chemistry 🇯🇵🤝🇮🇹 A huge honor to host outstanding Japanese and Italian scientists in Bari. Inspiring talks and posters all around! Thanks to all participants and the amazing @Luisi_Lab team! @farmuniba

⭐️𝐓𝐡𝐫𝐢𝐥𝐥𝐞𝐝 𝐭𝐨 𝐩𝐫𝐞𝐬𝐞𝐧𝐭 𝐦𝐲 𝐟𝐢𝐫𝐬𝐭 𝐩𝐨𝐬𝐭𝐞𝐫 at the 𝐉𝐚𝐩𝐚𝐧𝐞𝐬𝐞–𝐈𝐭𝐚𝐥𝐢𝐚𝐧 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐨𝐧 𝐎𝐫𝐠𝐚𝐧𝐢𝐜 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲, and even more honored that it was awarded the 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 𝐏𝐫𝐢𝐳𝐞!🏆 @NathoPhilipp @JisocSymposium @Luisi_Lab

It was very inspiring to attend the presentations given by such distinguished guest speakers at #JISOC2025: Prof. Keiji Maruoka (Kyoto University); Prof. Luisa De Cola (University of Milan); Prof. Yoshiaki Nishibayashi (Tokyo University) - part 1 @Luisi_Lab

It was very inspiring to attend the presentations given by such distinguished guest speakers at #JISOC2025: Prof. Gianluca Farinola (University of Bari); Prof. Motomu Kanai (Tokyo University); Prof. Francesca Paradisi (University of Bern) - part 2 @Luisi_Lab

It is a great honour that Prof. Mikiko Sodeoka is the first speaker at JISOC 2025, showing us the past, present and future prospects in late transition metal enolate chemistry! #JISOC2025 @Luisi_Lab

Italy and Japan finally together: JISOC 2025 has begun in Bari! Prof. Renzo Luisi, Prof. Paolo Melchiorre, Prof. Gianluca Maria Farinola and Prof. Keiji Maruoka opened this unique event. @Luisi_Lab @SCIorganica

European Researchers' Night 2025 Bari @MSCActions #ExpandFlow @Luisi_Lab

Congrats to Shijin, Drew, and Martin on publication of this C-H arylation with remarkable terminal selectivity! 3,5-lutidine turns out to be key! Check it out @ChemEurJ …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Safer. Smarter. Scalable. That’s why we automate. #SusPharma #GreenTech