Luke Marchetti

Excited to share my work so far on a new moiety in anion recognition: Amido-squaramides! Can't wait to investigate these cool new molecules further in the coming weeks 🧐 @rob_elmes @MaynoothChem #vMASCposter (poster number 22) #LoveIrishResearch

My New Years resolutions: 1. Survive. 2. Finish PhD. That’s it.

@Harlei_Martin @boconline @MaynoothChem Thanks hen 🥰

@LukeMarchetti @boconline @MaynoothChem Congrats Luke 👏🥳 so well deserved!!

Absolutely delighted to have been awarded the @boconline postgraduate bursary for @MaynoothChem this morning. Thanks to everyone that tuned in to listen to my seminar on my PhD project.

@johno_mccarron @boconline @MaynoothChem Thanks John 🥳

@LukeMarchetti @boconline @MaynoothChem Congrats luke. 👌👍 hard work pays off!!!

Big shout out to my supervisor, @rob_elmes and the rest of the Elmes Group for their continued support!

@SteelyBarrett Thanks Ste! Congrats on the teaching award, you love to see it

@MaryanneCooks @MaynoothChem @boconline Thanks, Maryanne! Delighted to have received such a flattering introduction and to be able to present my work so far 😊

Annual postgraduate awards ceremony this morning in @MaynoothChem . Huge thanks to @boconline for their long- standing and continued support of our postgraduate program! Huge congrats @LukeMarchetti for his ridiculously impressive research portfolio, amazing teaching & outreach!

doi.org/10.1002/chem.2…. TRANSMEMBRANE TRANSPORT OF BICARBONATE UNRAVELED! Check out our VIP paper in @ChemEurJ . A great project developed with @HennieValkenier at the @ULBruxelles and with exceptional collaborators @Steve_JButler @APDBris @BambusurilGroup . Open access!

Huge congratulations to the Dept. Chemistry @MaynoothChem for achieving an Athena SWAN Bronze award 👏👏- reflecting work undertaken to advance gender equality for staff and students @MU_AthenaSwan @hea_irl @EqualityMU @MaynoothUni

Getting ready to go to the lab knowing full well that the experiment didn't work

Really pleased to see the latest review from our lab @MaynoothUni on '1,8-Naphthalimide based fluorescent sensors for enzymes' out in Coord Chem Rev. Lots of hard work from @ConorGeraghtyy and @ConorWynne4 @MuLonsdale @SSPCentre. Free to view until May authors.elsevier.com/a/1cmQc2Tz3qyG6

nothing has such drastic effects on an organic chemist’s mood like NMR spectra

Research romance #science #microbiology #AcademicValentines

@lmartinezcrespo @rob_elmes @MaynoothChem Thanks Luis 😊

@LukeMarchetti @rob_elmes @MaynoothChem Cool! Good luck with it. pubs.rsc.org/en/content/art…

Excited to share my work so far on a new moiety in anion recognition: Amido-squaramides! Can't wait to investigate these cool new molecules further in the coming weeks 🧐 @rob_elmes @MaynoothChem #vMASCposter (poster number 22) #LoveIrishResearch

@HennieValkenier @rob_elmes @MaynoothChem Thanks Hennie! We're still in the early stages of the project at the moment, pKa determination is coming up soon. I'd reckon that the pKa is slightly less than regular squaramides due to the carbonyl stabilising the conjugate base. No evidence yet, of course, just a hunch!

@LukeMarchetti @rob_elmes @MaynoothChem Hi Luke, very nice work and and a new binding motif! Do you know how the pKa of these amido-squaramides compares to that of regular squaramides?

@lmartinezcrespo @rob_elmes @MaynoothChem I've been trying to grow crystals of the host:guest complex so we can do some x-ray crystallography to determine this. No success so far in obtaining crystals, but I'm continuing to try! (2/2)

@lmartinezcrespo @rob_elmes @MaynoothChem Hi Luis! It is definitely possible there is some intramolecular H-bonding affecting the anion binding. I'd guess that the conformation I have depicted in the poster is different than what's what is actually going on. (1/2)

@TABarendt - the squaramide would pick back up a H from the H2O, reversing the deprotonation. However, as water is a competitive H-bond donor for anions, the binding affinity would likely decrease in the presence of water! Thanks for your questions 😊(3/3)

@TABarendt Chloride is basic enough to form a strong interaction but not basic enough to deprotonate. The size of Cl- is complementary to the binding site, also! If water was added the risk of deprotonation would *probably* be lessened due to H2O being a protic solvent (2/3)

Some more great results from the Elmes' Group! Can't wait to see what else Luke helps to produce over the next four years 👨‍🔬