Lysosome Articles

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF doi.org/10.1126/sciadv…

Physical training and high-protein diet improved muscle strength, parent-reported fatigue, and physical quality of life in children with Pompe disease. doi.org/10.1002/jimd.1…

Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence. doi.org/10.1091/mbc.E2…

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells. doi.org/10.1038/s41467…

Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. doi.org/10.1016/j.molc…

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells. doi.org/10.1242/dmm.05…

Association of Rare Variants in ARSA with Parkinson's Disease. doi.org/10.1002/mds.29…

An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes. doi.org/10.15252/embr.…

Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. doi.org/10.1172/JCI138…

Novel phosphorylation of Rab29 that regulates its localization and lysosomal stress response in concert with LRRK2. doi.org/10.1242/jcs.26…

The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG 4 and VAC14 mutants. doi.org/10.1371/journa…

Genetic ablation of Saposin-D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination. doi.org/10.1111/jnc.15…

Arf1-PI4KIIIβ positive vesicles regulate PI(3)P signaling to facilitate lysosomal tubule fission. doi.org/10.1083/jcb.20…

Dynamic Measurement of Endosome-Lysosome Fusion in Neurons Using High-Content Imaging. doi.org/10.1007/978-1-…

Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks: A Phase 3 Randomized Clinical Trial. doi.org/10.1001/jamane…

Lysosomal calcium loading promotes spontaneous calcium release by potentiating ryanodine receptors. doi.org/10.1016/j.bpj.…

Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo. doi.org/10.1038/s41589…

Local translation in microglial processes is required for efficient phagocytosis. doi.org/10.1038/s41593…

C9ORF72 suppresses JAK-STAT mediated inflammation. doi.org/10.1016/j.isci…

Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice. doi.org/10.1016/j.omtm…