Movement Disorders Clinical Practice

PD & fractures: we’re missing the mark. Only 12% on bone protection pre-fracture → just 53% @48wks post-fracture. -Men, rib #, care home residents = least treated -Vertebral # drives treatment—but shouldn’t be the trigger -Think bone health EARLY in Parkinson’s loom.ly/CN43aPU

The Japanese anime character Naruto Uzumaki has for generations inspired children and adults. in this study Naruto's running style was observed and described in children and interpreted as a evidence of a cultural meme rather than a pathological disorder of movement. loom.ly/hclviEI

Continuous subcutaneous apomorphine infusion (CSAI) may benefit selected patients with multiple system atrophy. In a French multicenter cohort (n=50), CSAI improved motor symptoms in 90% at 6 months, with acceptable tolerability. #MSA #Parkinsons #DAT #Apomorphine loom.ly/BL2WFJo

Among PDRD patients with significant palliative needs, nearly half had an ED visit and one in five were hospitalized annually. Home-based services were used by over a third. Acute care use remains substantial underscoring gaps in supportive care delivery. loom.ly/ni_LYAc

Foslevodopa/foscarbidopa improves urinary disturbances, nocturia and quality of life in PD patients. Both overnight continuous dopaminergic stimulation and increasing the total dose of L-dopa contribute to improve overactive bladder. loom.ly/7apCuI8

The 'Swallow Tail Sign' gets an upgrade! Absence of dorsolateral nigral hyperintensity on SMWI is a robust, reproducible marker of neurodegenerative parkinsonism—works early, survives real‑world controls, and fits existing MRI pathways! @movedisorder loom.ly/VaFEiNw

MRgFUS thalamotomy shows strong tremor control even in patients ≥80 — with 95.6% improving and side‑effect rates similar to younger adults. Learning point: Age alone shouldn’t exclude MRgFUS; balance issues are common but usually improve or resolve. …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Two siblings with BCL11B‑related early‑onset dystonia showed striking, long‑lasting motor improvement after GPi‑DBS,with >50% BFMDRS-M reduction. A reminder that genetic dystonias can be highly DBS‑responsive—mutation type, phenotype & timing matter. …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Exocrine dysfunction in PD is common & early—drooling, dry mouth/eyes, seborrhea, rhinorrhea, sweating & GI issues all reflect autonomic + α‑synuclein pathology. Clinician tip: Ask about these symptoms—they’re underrecognized but highly impactful! …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Subcutaneous foslevodopa/foscarbidopa (fLD/fCD) was thought to overcome systemic and nutritional complications of LCIG therapy, but peripheral neuropathy can still emerge. Baseline + ongoing vitamin & nerve monitoring recommended! …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

New scoping review highlights how FXTAS remains under diagnosed in Latin America. Key takeaways: • Classic signs = ataxia & intention tremor • Cerebral atrophy more common than MCP sign • Atypical phenotypes (spasticity, PSP‑like, rapid dementia) • Urgent need for better access to genetic testing & clinician awareness loom.ly/YRyRVdg

A global MDS member survey on career and work environment found pronounced gender disparities in the field. Data were proportionally representative of Pan-America, Asia-Oceania, Europe, and Africa. @movedisorder …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

New case series:In PD dementia,cognitive fluctuations were consistently time‑locked to hypotensive episodes on 24‑hr BP monitoring — independent of levodopa timing. Recognizing & treating hypotension may be key to improving cognition. @AMahajanMD @UCMovDis …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

The Parkinson’s Pals program reduced loneliness and demoralization in pwPD after just 8 virtual sessions, while boosting student PD knowledge. Low‑cost, scalable psychosocial care in action! loom.ly/-dCdb0U

New MDCP Pearl: Digital Gait Measures Discriminate People with Friedreich's Ataxia from Healthy Controls loom.ly/WPtnCjQ

Long-term data from 31 orthostatic tremor patients show that about half continued perampanel, experiencing better social functioning, mental health, and reduced pain. Benefits are meaningful, but side effects remain frequent and may outweigh the benefit in some OT patients. loom.ly/pz6jNwg

Can we identify patients at risk for a first fall before it occurs? Using routinely collected motor and cognitive data from clinic visits, we developed and validated a model to estimate first-fall risk in Parkinson’s disease, supporting earlier, proactive clinical assessment. loom.ly/-7dF36k

Extensive hemispheric vasogenic edema after MRgFUS thalamotomy for essential tremor — first report! Procedure parameters were standard Rapid recognition + high‑dose steroids → full neurological recovery by 12 months. Takeaway for clinicians: remain vigilant for delayed neurological decline post‑MRgFUS & manage promptly. loom.ly/GOIJapc

High dairy intake = ↑ PD risk in men (but not women), but evidence is weak + observational only. No basis for advising dairy restriction. Mechanisms unclear (pesticides? uric acid? hormones). Useful reminder: association ≠ causation. loom.ly/f1RjCKE

New insights for DBS teams: PD patients awaiting STN‑DBS often show less active & more emotion‑focused coping, which correlates with ↑ anxiety, depression, psychosomatic symptoms & ↓ QoL. Poor executive function = fewer adaptive coping strategies. Simple coping screens (e.g., UCL) may flag patients needing extra pre‑op support. loom.ly/ZAKrvmQ