Molecular Imaging Chemistry Laboratory

Great to see [18F]CETO making real impact! ukri.org/news/new-diagn…

Another year, another Secret Santa...Merry MICLmas to all!☢️

MICL contingent will he there in force!

Great to see this initiative kicking off woth our very own @SelenaSephton!!!

Great to see this out!

We discuss the potential miRNA have as PET radiotracers and PET targets. Several approaches are considered utilising targeting with small molecules or direct radiolabelling of ASOs. @MICLCambridge onlinelibrary.wiley.com/doi/10.1002/hl…

Think we were overdue a lab clean...

👉 Join us for an enlightening presentation on "The Pathway to DJ-1 Based Precision Therapies for Parkinson’s by Maintaining Cellular Redox Homeostasis." by Gergely Toth together with Darwin Entrepreneurs Club. ⭐️⭐️ Abstract ⭐️⭐️ This talk will explore the critical role of DJ-1 protein in cellular survival, its connection to redox homeostasis, and the implications for aging-related diseases. Discover how oxidative stress leads to DJ-1 dysfunction, contributing to both familial and sporadic Parkinson’s disease. The session will also cover innovative therapeutic strategies targeting DJ-1, including pharmacological chaperones and enzyme replacement therapies, aimed at combating Parkinson’s. Additionally, learn about the potential of using various oxidized states of DJ-1 as biomarkers for Parkinson’s disease, assessed through novel ELISA techniques. This presentation will be extremely insightful for those interested in the latest advancements in neurodegenerative disease research and therapy. ⭐️⭐️About Gergely⭐️⭐️ Gergely Tóth (PhD, MBA) is the CEO, CSO and founder of Cantabio Pharmaceuticals, Inc. (USA), a preclinical stage biopharmaceutical company focusing on developing novel disease modifying precision therapeutics and diagnostics for neurodegenerative diseases. In addition, Dr. Tóth is an Honorary Associate Professor at the School of Pharmacy at University College London lecturing to graduate students on topics as the business of biotech and bioentrepreneurship. Look Forward to Seeing you There! 😁

Our latest work with @Sanford_Lab & @Merck introduces #HighThroughput #Radiochemistry, and reduces the time for identifying & optimizing radiolabeling from weeks/months to just a few days. Funded by @NIBIBgov & out in @J_A_C_S, we're excited to share this: pubs.acs.org/doi/10.1021/ja…

Check out Yanyan's new chapter with @cantabio on measuring interactions of small-molecules with tau fibrils with MST! link.springer.com/protocol/10.10…

Next we've got Simon (CHEM-076) and Jieyu (CHEM-079) presenting their posters tonight!

Starting off with Simon and Selena chairing a full house for the @ESMI_SG_NEURO session! #EMIM2024

The MICL crew has landed in Porto for #EMIM2024! Looking forward to a great meeting!

It was amazing having Florence Pugh in our lab at @Cambridge_Uni, speaking about dementia and our research work - big thanks to her for being such a great ambassador for @racingdementia! Her full interview: telegraph.co.uk/christmas/2024…

Hard at work.

A very powerful and well written piece that is worth a read around #Huntingtonsdisease @racingdementia telegraph.co.uk/christmas/2023…

Was fantastic to be able to contribute to this!

The MICL crew will be there in force💪Looking forward to a great meeting in March!

Congrats to former MICL lab member @hirdmj on the new publication👏👏👏

First Neurotalk of the academic year! Join us at the Cambridge tap on Tuesday the 10th of October from 7pm. We will hear from three exciting speakers all about emotions! 🎭 This event is open to anyone and will double as a welcome party to new and old friends of CamBrain alike!